Evolution of Animal Lectins

Hirabayashi, Jun; Kasai, Ken‐ichi

doi:10.1007/978-3-642-48745-3_3

Cited by 16 publications

(10 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…contain two homologous CRDs in tandem in a single polypeptide chain; and c) the chimera-type galectin-3 which displays a CRD connected to a non-lectin N-terminal region responsible for oligomerization [42]. Although galectins lack the typical signal sequence required for the classical secretory pathway, most of them are externalized through a non-classical mechanism that is still not clearly understood [43].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways

Rabinovich

Conejo-García

2016

Journal of Molecular Biology

View full text Add to dashboard Cite

Along with the discovery of tumor-driven inflammatory pathways, there has been a considerable progress over the past 10years in understanding the mechanisms leading to cancer immunosurveillance and immunoediting. Several regulatory pathways, typically involved in immune cell homeostasis, are co-opted by cancer cells to thwart the development of effective antitumor responses. These regulatory circuits include the engagement of inhibitory checkpoint pathways (CTLA-4, PD-1/PD-L1, LAG-3 and TIM-3), secretion of immunosuppressive cytokines (TGF-β, IL-10), and expansion and/or recruitment of myeloid or lymphoid regulatory cell populations. Elucidation of these pathways has inspired the design and implementation of novel immunotherapeutic modalities, which have already generated clinical benefits in an important number of cancer patients. Galectins, a family of glycan-binding proteins widely expressed in the tumor microenvironment (TME), have emerged as key players in immune evasion programs that differentially control the fate of effector and regulatory lymphoid and myeloid cell populations. How do galectins translate glycan-containing information into cellular programs that control immune regulatory cancer networks? Here, we uncover the selective roles of individual members of the galectin family in cancer-promoting inflammation, immunosuppression, and angiogenesis. Moreover, we highlight the relevance of corresponding glycosylated ligands and counter-receptors and the emerging function of these lectins as biological liaisons connecting commensal microbiota, systemic inflammation, and distal tumor growth. Understanding the molecular and cellular components of galectin-driven regulatory circuits, the implications of different glycosylation pathways in their functions and their clinical relevance in human cancer might lead to the development of new therapeutic approaches in a broad range of tumor types.

show abstract

Section: Accepted Manuscriptmentioning

confidence: 99%

Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways

Rabinovich

Conejo-García

2016

Journal of Molecular Biology

View full text Add to dashboard Cite

show abstract

“…15 Gals are defined as lectins having both galactose-binding ability and amino-acid sequences that characterize Gals. 16 Gals are members of the mammalian b-galactoside-binding proteins and recognize Galb1-4GlcNAc sequences of several cell surface oligosaccharides (Fig.…”

Section: Role Of Galectins In Trophoblast Invasionmentioning

confidence: 99%

REVIEW ARTICLE: Governing the Invasive Trophoblast: Current Aspects on Intra‐ and Extracellular Regulation

Fitzgerald

Germeyer

Huppertz

et al. 2010

American J Rep Immunol

View full text Add to dashboard Cite

Citation Fitzgerald JS, Germeyer A, Huppertz B, Jeschke U, Knöfler M, Moser G, Scholz C, Sonderegger S, Toth B, Markert UR. Governing the invasive trophoblast: current aspects on intra‐ and extracellular regulation. Am J Reprod Immunol 2010This review summarizes several aspects especially of regulating factors governing trophoblast invasion. Those include the composition of the extracellular matrix containing a variety of matrix metalloproeinases and their inhibitors, but also intracellular signals. Furthermore, a newly described trophoblast subtype, the endoglandular trophoblast, is presented. Its presence may provide a possible mechanism for opening and connecting uterine glands into the intervillous space. Amongst others, two intracellular signalling pathways are crucial for regulation of trophoblast functions and development: Wnt‐ and signal transducer and activator of transcription (STAT)3 signalling. Wnt signalling promotes implantation, placentation and trophoblast differentiation. Several Wnt‐dependent cascades and regulatory mechanisms display different functions in trophoblast cells. The STAT3 signalling system is fundamental for induction and regulation of invasiveness in physiological trophoblastic cells, but also in tumours. The role of galectins (Gal) in trophoblast regulation and placenta development comes increasingly into focus. The Gal‐ 1–4, 7–10 and 12–14 have been detected in humans. Detailed information is only available for Gal‐1, ‐2, ‐3, ‐4, ‐9 and ‐12 in endometrium and decidua. Gal‐1, ‐3 and ‐13 (‐14) have been detected and studied in trophoblast cells.

show abstract

“…Lectins are carbohydrate containing conjugate substances other than immunoglobulins or enzymes.Their presence are mapped into plants ,animals ,fungi and bacteria (Hirabayashi and Kasai,1997).Lectins are capable of specific recogniation of reversible binding to carbohydrate moieties of complex glycoconjugates without altering the covelent structure of any of the recognized ligands (Horak ,1996).Among the known lectins that are abiqitous in the natural biological systems ,animal lectins mediate biological processes ranging from protein folding and trafficking to the modulation of cellcell and cell matrix interaction s (Hirabayashi and Kasai ,1997).In general ,lectins can be grouped in eight groups .Animal lectins .however ,occupied the first six are namely,Galectins,C type, selectins,collectins, annexins and the invertebrate body protection factors (Drickamer and Tylor,1998; Hirabayashi and Kasai,1997).Although lectins are considered to be ubiquitous and important molecules in organisms,but data on lectins in helminth are scarce (Horak and Vanderknaop,1997;Hirabayashi andKasai,1997,Guteirrez,2000). These glycolprotein have been found mainly in nematodes .In trermatodes however data are even more scarce (Horak ,1996;Horak and Vanderknaop,1997).The mapped termatodes for presence of lectins were ; Schistosoma mansoni ,Tricobilharzia szidati,Diplostomum pseudospathaceum and Acanthostomum brauni (Horak ,1996) Fasciola hepatica The trematod helminth ,was wide,wide shoulders and large cephalic cone as well as branched seca .Ventral and dorsal suckers ,the ventral one located at the base of cephalic cone .The size of the fluke was of up to cm in length by 1.3 cm in width and 0.1 cm in thickness (Guteirrez ,2000),studies have been shown ;screted thioredoxin peroxidase product and secretory excretory (Donnely et al .…”

Section: Introductionmentioning

confidence: 99%

The immunogenicity,allerginicity and immunomodulating potentials as well as shared antigenicity of Fasciola hepatica (whole body lectin FHL) with E .coli in rabbit

Shnawa¹,

G.²,

Al-Allak³

2010

QJVMS

View full text Add to dashboard Cite

The Fasciola hepatica surface and whole body lectins (FHLs) were separated partially purified and tentatively identified. They are of protein nature and of glucose, lactose, and mannose-binding potentials. As well as they agglutinate sheep red corpuscles 2% suspension. FHLs are T lymphocyte mitogens, but the whole body lectins were more potent than surface lectins. Thus, whole-body lectin was selected for further study.T he whole body lectin stimulates specific antibody formation at both mucosal and systemic level, post to an oral immunization program in rabbits.T he immunodominant epitope can be of B cell or Th2 dependent nature and in combination with E. coli "O" antigen induces mucosal tolerance. E. coli induce significant leukocyte migration inhibitory factor ( LIF ) and the combination of E .coli -FHLs induced both significant macrophage migration inhibitory factor (MIF) and LIF in the immunoprimed rabbits.FHLs posses augmenting potential for the tuberculin skin DTH reaction indicating its cellular immunopotentiating ability. Bilateral humoral and cellular shared immunogenicity. Such shared character may be helpful in immunoprotection model of E.coli infection in one hand and source of confusion in immunodiagnosis of Fasciola infection, on the other hand. The conclusion of this study FHL functional epitope mapping, maps the following possible epitope, B or Th2 dependent.Th1, Tdth and or shared immunodominant epitopes.

show abstract

Evolution of Animal Lectins

Cited by 16 publications

References 140 publications

Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways

Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways

REVIEW ARTICLE: Governing the Invasive Trophoblast: Current Aspects on Intra‐ and Extracellular Regulation

The immunogenicity,allerginicity and immunomodulating potentials as well as shared antigenicity of Fasciola hepatica (whole body lectin FHL) with E .coli in rabbit

Contact Info

Product

Resources

About