Evolution of dynamics of physico-chemical and mechanical properties of hydroxyapatite with fluorine addition and degradation stability of new matrices

Erdem, Ümit; Doğan, Deniz; Bozer, Büşra Moran; Karaboğa, Seda; Turkoz, Mustafa; Metin, Ayşegül Ülkü

doi:10.1016/j.jmbbm.2022.105454

Cited by 1 publication

(1 citation statement)

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“…Hydroxyapatite is used as such in toothpastes [25][26][27] and bone regeneration [28,29], or as substituted in its lattice with various physiological elements to enhance its bioactivity, like Zn [30], Zn-carbonate [31], Sr [32,33], Zn and Sr [34], Cu and Zn [35], Zn and fluoride [36], fluorine [37], Ag and fluoride [38], Mg and Sr [39], Mg [40], Mg and Zn [41], Mg and Si [42], Ag [43], and Si [44]. These components play various roles; for some, the particular role they play in the substituted HAP is known; for others, it is only assumed.…”

Section: Introductionmentioning

confidence: 99%

Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel

Florea,

Pop,

Benea

et al. 2023

Biomimetics

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This work aimed to compare the effect of four new toothpastes (P1–P4) based on pure and biomimetic substituted nano-hydroxyapatites (HAPs) on remineralization of human enamel. Artificially demineralized enamel slices were daily treated for ten days with different toothpastes according to the experimental design. Tooth enamel surfaces were investigated using atomic force microscope (AFM) images and surface roughness (Ra) determined before and after treatment. The surface roughness of enamel slices was statistically analyzed by one-way ANOVA and Bonferroni’s multiple comparison test. X-ray diffraction (XRD) and Fourier transform infrared (FTIR) data revealed the HAP structure with crystal sizes between 28 and 33 nm and crystallinity between 29 and 37%. The average size of HAP particles was found to be between 30 and 40 nm. The Ra values indicated that P3 (HAP-Mg-Zn-Sr-Si) toothpaste was the most effective after 10 days of treatment, leading to the lowest mean roughness. The P3 and P2 (HAP) toothpastes were found to be effective in promoting remineralization. Specifically, their effectiveness can be ranked as follows: P3 = P2 > P4 (HAP-Mg-Zn-Si) > P1 (HAP-Zn), considering both the chemical composition and the size of their constitutive nanoparticles. The proposed toothpastes might be used successfully to treat early tooth decay.

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