Evolution of <i>tuf</i> genes: ancient duplication, differential loss and gene conversion

Lathe, Warren C.; Bork, Peer

doi:10.1016/s0014-5793(01)02639-4

Cited by 57 publications

(53 citation statements)

References 12 publications

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“…EF-Tu is among the most slowly evolving proteins known (Lathe and Bork, 2001). The first 300 hits obtained by a BLAST analysis with the N terminus of E. coli EF-Tu in the nonredundant GenBank database covered bacterial EF-Tu sequences from many different species and diverse taxons (data not shown).…”

Section: Discussionmentioning

confidence: 99%

The N Terminus of Bacterial Elongation Factor Tu Elicits Innate Immunity in Arabidopsis Plants

et al. 2004

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Innate immunity is based on the recognition of pathogen-associated molecular patterns (PAMPs). Here, we show that elongation factor Tu (EF-Tu), the most abundant bacterial protein, acts as a PAMP in Arabidopsis thaliana and other Brassicaceae. EF-Tu is highly conserved in all bacteria and is known to be N-acetylated in Escherichia coli. Arabidopsis plants specifically recognize the N terminus of the protein, and an N-acetylated peptide comprising the first 18 amino acids, termed elf18, is fully active as inducer of defense responses. The shorter peptide, elf12, comprising the acetyl group and the first 12 N-terminal amino acids, is inactive as elicitor but acts as a specific antagonist for EF-Tu–related elicitors. In leaves of Arabidopsis plants, elf18 induces an oxidative burst and biosynthesis of ethylene, and it triggers resistance to subsequent infection with pathogenic bacteria

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Section: Discussionmentioning

confidence: 99%

The N Terminus of Bacterial Elongation Factor Tu Elicits Innate Immunity in Arabidopsis Plants

et al. 2004

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“…There is a possibility that some orthologs inferred in this study were involved in differential loss after duplication. It has been shown that differential loss and gene conversion might happen after ancient duplication (Lathe and Bork 2001), and gene duplication followed by differential loss can always be invoked as an alternative to lateral gene transfer and vice versa (Gogarten and Townsend 2005). Differential loss will result in a relatively high level of divergence at the sequence level.…”

Section: Discussionmentioning

confidence: 99%

Does Gene Translocation Accelerate the Evolution of Laterally Transferred Genes?

Hao

Golding

2009

Genetics

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Lateral gene transfer (LGT) and gene rearrangement are essential for shaping bacterial genomes during evolution. Separate attention has been focused on understanding the process of lateral gene transfer and the process of gene translocation. However, little is known about how gene translocation affects laterally transferred genes. Here we have examined gene translocations and lateral gene transfers in closely related genome pairs. The results reveal that translocated genes undergo elevated rates of evolution and gene translocation tends to take place preferentially in recently acquired genes. Translocated genes have a high probability to be truncated, suggesting that translocation followed by truncation/deletion might play an important role in the fast turnover of laterally transferred genes. Furthermore, more recently acquired genes have a higher proportion of genes on the leading strand, suggesting a strong strand bias of lateral gene transfer.

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“…For example, multiple independent gene conversion events were detected in outer membrane proteins of H. pylori and C. pneumoniae (Jordan et al, 2001). In another study, gene conversions were also detected by phylogenetic evidence in the tuf genes of different bacteria (Lathe III and Bork, 2001).…”

Section: Introductionmentioning

confidence: 92%

“…Some of them exhibit extraordinary similarity between all its members, which suggests a recent origin after duplication, or a homogenizing mechanism called gene conversion . Gene conversion has been widely documented in diverse multigene families, including the rRNA genes in Escherichia coli (Liao, 2000), tuf in Salmonella typhimurium (Abdulkarim and Hughes, 1996) and Vibrio cholerae (Lathe III and Bork, 2001), pilE in Neisseria gonorrhoeae and N. meningitidis (Haas and Meyer, 1986;Kline et al, 2003), and hop in Chlamydia pneumoniae and Helicobacter pylori (Jordan et al, 2001), among others . Gene conversion also plays essential roles in antigenic variation, an important mechanism in bacterial pathogens to evade the host immune system, as well as other positive and detrimental roles (Deitsch et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic analysis reveals gene conversions in multigene families of rhizobia

Hernández-Salmerón¹,

Santoyo²

2011

Genet. Mol. Res.

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ABSTRACT. Gene families are an important and intrinsic trait of rhizobial species. These gene copies can participate in non-reciprocal recombination events, also called gene conversions. Gene conversion has diverse roles, but it is usually implicated in the evolution of multigene families. Here, we searched for gene conversions in multigene families of six representative rhizobial genomes. We identified 11 gene families with different numbers of copies, genome location and function in CFN42 and CIAT652 strains of Rhizobium etli, Rhizobium sp NGR234, Mesorhizobium loti MAFF303099, Sinorhizobium meliloti 1021, and Bradyrhizobium japonicum USDA110. Gene conversions were detected by phylogenetic inference in the nifD and nifK gene families in R. etli. Sequence analysis confirmed multiple gene conversions in these two gene families. We suggest that gene conversion events have an important role in homogenizing multigene families in rhizobia.

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Evolution of tuf genes: ancient duplication, differential loss and gene conversion

Cited by 57 publications

References 12 publications

The N Terminus of Bacterial Elongation Factor Tu Elicits Innate Immunity in Arabidopsis Plants

The N Terminus of Bacterial Elongation Factor Tu Elicits Innate Immunity in Arabidopsis Plants

Does Gene Translocation Accelerate the Evolution of Laterally Transferred Genes?

Phylogenetic analysis reveals gene conversions in multigene families of rhizobia

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