Land-use changes have profound effects on both socio-economic development and the environment. As a result, to optimize land-use planning and management, models are often employed to identify land-use patterns and their associated driving forces. In this work, physical and socioeconomic factors within the Yangtze River Delta Urban Agglomeration (YRDUA) from 2000 to 2015 were identified, integrated, and used as the foundation for a CLUMondo model. Subsequently, the Markov model and the CLUMondo model were combined to predict land-use changes in 2035. Natural growth (NG), economic development (ED), ecological protection (EP), and coordinated social and economic development (CSE) scenarios were set according to the land-use date in the assessment. Results showed that: (1) From 2000 to 2015, urban land increased by 8139.5 km2 (3.93%), and the paddy field decreased by 7315.8 km2 (8.78%). The Kappa coefficient of the CLUMondo model was 0.86, indicating that this model can be used to predict the land-use changes of the YRDUA. (2) When this trend was used to simulate landscape patterns in 2035, the land-use structure and landscape patterns varied among the four simulated urban development scenarios. Specifically, urban land increased by 47.6% (NG), 39.6% (ED), 32.9% (EP), and 23.2% (CSE). The paddy field was still the primary landscape, with 35.85% NG, 36.95% ED, 37.01% EP, and 36.96% CSE. Furthermore, under all four scenarios, the landscape pattern tended to simplify and fragment, while connectivity and equilibrium diminished. The results provided herein are intended to elucidate the law of urban agglomeration development and aid in promoting urban sustainable development.