Evolution of neuronal density in the ageing thalamic reticular nucleus

Ramos, Raddy L.; Requena, V.; Díaz, F.; Villena, Alicia; Vargas, I. Pérez de

doi:10.1016/0047-6374(95)01617-9

Cited by 14 publications

(10 citation statements)

References 35 publications

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“…However, in the visual cortex of monkeys (Peters, 1993) and Sprague-Dawley rats (Peters et al, 1983) this parameter is stable. On the other hand a significant increase was observed in the thalamic reticular nucleus between 24 and 30 months of Wistar rats (Ramos et al, 1995). Studies carried out on the dLGN of Sprague-Dawley rats (Satorre et al, 1985) and monkeys (Ahmad and Spear, 1993) have shown a decrease in numerical density with age, although the number of neurons/mm 3 reported by Satorre et al (1985) is smaller than the one we have observed.…”

Section: Discussioncontrasting

confidence: 69%

“…A similar decrease in neuronal density, with no significant change in the number of neurons, has been observed in the dLGN of rats and monkeys (Satorre et al, 1985;Ahmad and Spear, 1993). Recently, we reported an increase in neuronal density in the thalamic reticular nucleus (TRN) of rats once these rodents have fully entered old age (Ramos et al, 1995 RECORD 255:396-400 (1999) In a previous study (Villena et al, 1997) we have demonstrated that dLGN neurons undergo hypertrophy in the soma and nucleus between 24 and 30 months as compared to those from 3-month-old animals. In this work we have evaluated the changes in the total volume of the dLGN, as well as the density and the total number of neurons, with the aim of knowing whether or not neuronal loss occurs during old age.…”

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confidence: 79%

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Stereological age‐related changes in neurons of the rat dorsal lateral geniculate nucleus

et al. 1999

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Quantitative methods were used to compare the changes taking place in the volume of the dorsal lateral geniculate nucleus (dLGN) and corresponding neurons of young, adult and old rats. The study was carried out on male albino rats aged 3, 18, 24 and 28 months. In order to estimate the volume of the dLGN, neuronal volume density, numerical density and total number of neurons, we used serial sections stained according to the Klüver-Barrera technique and stereological methods. We found that dorsal lateral geniculate nucleus volume increases between 3 and 28 months, with a larger increase between 24 and 28 months. Neuronal volume density and numerical density of neurons are greater at 3 months and undergo a significant decrease between 24 and 28 months. Finally, the total number of neurons is shown to be smaller in adult and old animals than in younger ones, even though no significant variations are found between 18 and 28 months. Furthermore, this study confirms the need to analyze the total number of neurons and not just neuronal density if we want to correctly evaluate some of the microscopic changes occurring during senescence.

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Section: Discussioncontrasting

confidence: 69%

supporting

confidence: 79%

Stereological age‐related changes in neurons of the rat dorsal lateral geniculate nucleus

et al. 1999

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“…Then the recorded area is a cylinder with volume V s ϭ 0.0471 mm 3 for the small-diameter and V l ϭ 0.0804 mm 3 for the large-diameter electrode. The average density of rodent dorsal thalamus is ϳ23,000 neurons per mm 3 (Mooney and Miller 2007;Ramos et al 1995), which translates to ϳ1,083 local neurons that contribute to LFP s and ϳ1,849 neurons to LFP l , respectively. Our model is coherent with the passive neuronal electrical parameters known to undergo fast amplitude decay, which is proportional to the square of the distance to the point source (Pettersen and Einevoll 2008).…”

Section: Recording Volume Of the Lfp L And Lfp Smentioning

confidence: 99%

“…A similar exponential rule is used to identify extracellular spike signals (Henze et al 2000). A cylinder with a radius of 47 m contains on average 1,083 neurons in rat thalamus (Mooney and Miller 2007;Ramos et al 1995), which is the maximum number of possible recordable cells by a single small-diameter electrode. In this case, the total number of AV theta cells (23.7%) contributing to the LFP s will be ϳ257.…”

Section: Ratio Of Theta To Delta Spectral Powers Shares Concurrent Dymentioning

confidence: 99%

Oscillatory Entrainment of Thalamic Neurons by Theta Rhythm in Freely Moving Rats

Tsanov

Chah

Wright³

et al. 2011

Journal of Neurophysiology

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The anterior thalamic nuclei are assumed to support episodic memory with anterior thalamic dysfunction a core feature of diencephalic amnesia. To date, the electrophysiological characterization of this region in behaving rodents has been restricted to the anterodorsal nucleus. Here we compared single-unit spikes with population activity in the anteroventral nucleus (AV) of freely moving rats during foraging and during naturally occurring sleep. We identified AV units that synchronize their bursting activity in the 6-11 Hz range. We show for the first time in freely moving rats that a subgroup of AV neurons is strongly entrained by theta oscillations. This feature together with their firing properties and spike shape suggests they be classified as "theta" units. To prove the selectivity of AV theta cells for theta rhythm, we compared the relation of spiking rhythmicity to local field potentials during theta and non-theta periods. The most distinguishable non-theta oscillations in rodent anterior thalamus are sleep spindles. We therefore compared the firing properties of AV units during theta and spindle periods. We found that theta and spindle oscillations differ in their spatial distribution within AV, suggesting separate cellular sources for these oscillations. While theta-bursting neurons were related to the distribution of local field theta power, spindle amplitude was independent of the theta units' position. Slow- and fast-spiking bursting units that are selectively entrained to theta rhythm comprise 23.7% of AV neurons. Our results provide a framework for electrophysiological classification of AV neurons as part of theta limbic circuitry.

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“…The development of the brain is frequently associated with modifications in the numbers and densities of neurons. A decrease in the number of neurons in various centers of the nervous system has been reported (Ramos et al, 1995; Satorre et al, 1985). Thus, a decrease in neuronal density has been observed for the human somatosensory cortex (Henderson et al, 1980), in the frontal association cortex (Terry et al, 1987), and in the nucleus basalis of Meynert (Mann et al, 1984; McGeer et al, 1984).…”

Section: Discussionmentioning

confidence: 98%

A developmental study of glutamatergic neuron populations in the ventrobasal and the lateral geniculate nucleus of the thalamus: Comparing Genetic Absence Rats from Strasbourg (GAERS) and normal control wistar rats

Kirazlı

Çavdar

Yıldızel

et al. 2016

Intl J of Devlp Neuroscience

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An imbalance of GABAergic inhibition and glutamatergic excitation is suspected to be the cause of absence epileptic seizures. Absence seizures are known to be generated in thalamocortical circuitry. In the present study we used light microscopy immunohistochemistry to quantify the density of glutamate+ve neurons at two developmental stages (P10 and P60) in two thalamic nuclei, the ventrobasal (VB) and lateral geniculate nucleus (LGN) in Wistar rats and compared the results with similar data obtained from genetic absence epilepsy rats from Strasbourg (GAERS). Rats were perfused transcardially with glutaraldehyde and paraformaldehyde fixative, then samples from VB and LGN were removed from each animal and sectioned. The glutamatergic neurons were labelled using light-microscopic glutamate immunohistochemistry. The disector method was used to quantify the glutamate+ve neurons in VB and LGN of GAERS and Wistar rats. The data were statistically analyzed. The distribution of the glutamate+ve neurons in the VB thalamic nucleus showed a significant reduction in the neuronal profiles per unit thalamic area from P10 to P60 in both Wistar and GAERS. The decrease was greater in the GAERS compared to the Wistar animals. However, in the LGN no reduction was observed either in the Wistar or in the GAERS. Comparing the density of glutamate+ve neurons in the VB thalamic nucleus of P10 of Wistar animals with of P10 GAERS showed statistically significant greater densities of these neurons in GAERS than in the Wistar rats. However no significant difference was present at P60 between the Wistar and GAERS animals. The disproportional decrease in GAERS may be related to the onset of absence seizures or may be related to neurogenesis of absence epilepsy.

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Evolution of neuronal density in the ageing thalamic reticular nucleus

Cited by 14 publications

References 35 publications

Stereological age‐related changes in neurons of the rat dorsal lateral geniculate nucleus

Stereological age‐related changes in neurons of the rat dorsal lateral geniculate nucleus

Oscillatory Entrainment of Thalamic Neurons by Theta Rhythm in Freely Moving Rats

A developmental study of glutamatergic neuron populations in the ventrobasal and the lateral geniculate nucleus of the thalamus: Comparing Genetic Absence Rats from Strasbourg (GAERS) and normal control wistar rats

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