Evolution of new narcotic substances and methods of their determination

Abstract

History of the appearance and evolution of synthetic narcotics in recent years is presented. The main attention is paid to two classes of narcotic substances received the widest distribution in the world, i.e., cannabimetics and synthetic cations. The main classes, problems of identification, and approaches to the determination of new narcotics are considered. Approaches and solutions used in the quantitative analysis and screening of narcotics are discussed along with some aspects of sample preparation to their determination and matrix effects. The specific features of the determination of new narcotics in commercial products and biological samples are considered separately. Present day methods of chromatography-mass spectrometry are most informative for timely revealing new narcotic substances, studying their metabolism, and developing reliable methods for the screening of native and biological samples.

Identification of Furanoylfentanil and its Metabolites in Human Urine

“…Previously a number of new synthetic drugs and its metabolites were described [5][6][7][8]. The development of new methods of non-targeted screening for toxicological purposes is still relevant.…”

Synthetic Cannabinoids Associated Acute Kidney Injury: Case Report

“…11 In addition, saliva and hair samples can be used to determine the substance. Only known substances can be examined by current methods.…”

Scopes of Bioanalytical Chromatography–Mass Spectrometry

“…Despite a large number of regulatory documents, the assessment of the uncertainty of this analysis cannot be performed within the framework of a general approach [96]. Because of the rapid expansion of illicit traffic in narcotic drugs, the procedures used for detecting biomarkers and establishing their belonging to a certain group of prohibited substances require the development of new approaches to improve the efficiency of laboratories at the stage of detecting analytes that will or will not be classified as target biomarkers [97]. Grigor'ev et al [98] noted the prevalence of the survey direction in chemical toxicological analysis because the list of controlled compounds is continuously expanded and formulated 17 limitations of the HPLC-MS/MS technique in the survey analysis.…”