Evolution of pigeon Newcastle disease virus strains

Meulemans, G.; Berg, T. P. van den; Decaesstecker, Mireille; Boschmans, Marc

doi:10.1080/0307945021000005897

Cited by 83 publications

(52 citation statements)

References 15 publications

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“…Some PPMV-1, with a cleavage site specific for velogenic viruses, show low virulence for chickens (Meulemans et al 2002). However, this may increase with three or four passages from bird to bird, during the spread of the virus in the infected flock of chickens (Alexander and Parsons 1986).…”

Section: Pathogenicity Of the Virusmentioning

confidence: 99%

“…It has been shown that some pigeon paramyxoviruses have ICPI below 0.7, even though they have a cleavage site of the F protein specific for virulent strains. Meulemans et al (2002) compared 240-bp sequences at the cleavage site F 2 /F 1 of PPMV-1 strains isolated in the years 1983-1984 and 1998-1999. The results showed that, during this period, three amino acid substitutions occurred at the cleavage site (from 112 GRQKRF 117 to 112 RR(Q/K/R)KRF 117 ).…”

Section: Pathogenicity Of the Virusmentioning

confidence: 99%

See 1 more Smart Citation

Occurrence, characteristics and control of pigeon paramyxovirus type 1 in pigeons

Pestka¹,

Stenzel²,

Koncicki³

2014

Polish Journal of Veterinary Sciences

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Newcastle disease (ND) is a highly contagious and devastating viral disease of poultry and other birds that has a worldwide distribution. ND in pigeons is called paramyxovirosis and is caused by antigenic "pigeon variant" of the virus (pigeon paramyxovirus type 1, PPMV-1).During PPMV-1 infections, central nervous system symptoms and sometimes high mortality are observed. In the case of infection with viscerotropic strains which exhibit specific affinity for the kidneys, the first observed sign is polyuria, and neural symptoms appear only in individual birds in the flock.Due to the similarity of symptoms of paramyxovirosis to the pigeon herpes virus infection (PHV), sodium chloride poisoning, overdose of ronidazole or vitamin B 1 deficiency, it is necessary to perform laboratory tests to make a correct diagnosis. After virus isolation PPMV-1 can be detected initially by haemagglutination assay (HA). PPMV-1 can be confirmed by conventional serological tests such a haemagglutination inhibition test (HI) or molecular-based techniques.In the prophylaxis of paramyxovirosis in pigeons, inactivated vaccines are used, administered by subcutaneous injection in various prevention programs. However, vaccination should be only one component of a strategy of PPMV-1 control, on a par with effective biosecurity and proper, effective methods of prevention and diagnostics of paramyxovirosis.

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Section: Pathogenicity Of the Virusmentioning

confidence: 99%

Section: Pathogenicity Of the Virusmentioning

confidence: 99%

Occurrence, characteristics and control of pigeon paramyxovirus type 1 in pigeons

Pestka¹,

Stenzel²,

Koncicki³

2014

Polish Journal of Veterinary Sciences

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“…Therefore this strain was classified as a typical pPMV-1 and was representative of recent European isolates (Meulemans et al , 2002). Putative specific motifs of the pigeon variant strains were also described in the editing site of the P gene and the intracellular domain of the HN gene (Barbezange & Jestin, 2003a), which were included in the fragments focused on in the present study.…”

Section: Rrqkrfigmentioning

confidence: 99%

Molecular study of the quasispecies evolution of a typical pigeon paramyxovirus type 1 after serial passages in pigeons by contact

Barbezange

Jestin

2005

Avian Pathology

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The quasispecies nature of a typical pigeon paramyxovirus type 1 (pPMV-1) was, for the first time, studied under conditions close to the natural infectious environment. The virus was serially passaged in pigeons by successive contacts. Viral heterogeneity was analysed in the kidneys and brain of five pigeons from the last contact, by reverse transcriptase-polymerase chain reactions performed on RNA directly extracted from the organ and targeting the P and HN genes of the virus. The viral diversity following in vivo passage was found to be different from that in the inoculum, but demonstrated the reality of the quasispecies concept for pPMV-1 strains. Moreover, some aberrant genomic RNAs comprising insertions in the P gene editing site or deletions in the HN gene were also detected, with possible consequences for the pathogenicity and infectivity of the virus.

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“…Some of the pigeon variant viruses (PPMV-1) examined have the sequence 112 G-R-Q/K-K-R-F 117 , but give high ICPI values (Meulemans et al, 2002). Thus there appears to be the requirement of at least one pair of basic amino acids at residues 116 and 115 plus a phenylalanine at residue 117 and a basic amino acid (R) at 113 if the virus is to show virulence for chickens.…”

mentioning

confidence: 99%