Evolution of rosmarinic acid biosynthesis

Petersen, Maike; Abdullah, Yana; Benner, Johannes; Eberle, David; Gehlen, Katja; Hücherig, Stephanie; Janiak, Verena; Kim, Kyung Hee; Sander, Marion; Weitzel, Corinna; Wolters, S.

doi:10.1016/j.phytochem.2009.05.010

Cited by 276 publications

(189 citation statements)

References 96 publications

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“…callus on MS with 3 % S. The higher S content (4 %) and elicitation with 100 lM MeJA seemed to be the best treatment for RA production in callus culture. Probably, the metabolism change caused by MeJA relies on the use of common intermediary precursors from phenylpropanoid pathway increasing the RA biosynthesis at CGA expense (Petersen et al 2009). Those factors were chosen for our experiments because of its influence not only on phenolic acids, but also on saponins production (Misawa 1994).…”

Section: Resultsmentioning

confidence: 99%

“…This compound has been reported to have various biological activities: antioxidative (reviewed in Matkowski 2008), distinct antiseptic, antiviral, antibacterial, antiphlogistic and anti-inflammatory, which make it an important agent for health promoting effects and a valuable product for cosmetic and food industries (Le Claire et al 2005;Park et al 2008;Petersen et al 2009). Chlorogenic acid has been studied because of its antioxidant (reviewed in Matkowski 2008) and other biological activities: antiviral, antibacterial, the blood glucose level lowering, antiinflammatory and anti-allergy (Gugliucci and MarkowiczBastos 2009).…”

Section: Introductionmentioning

confidence: 99%

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Accumulation of rosmarinic, chlorogenic and caffeic acids in in vitro cultures of Eryngium planum L.

Kikowska

Budzianowski

Krawczyk³

et al. 2012

Acta Physiol Plant

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Eryngium planum L. cell and organ cultures were maintained on Murashige and Skoog media (MS), supplemented with exogenous hormones of different types and various concentrations for high biomass growth. The callus and cell suspension cultures were treated with increased sucrose concentration and/or elicited by methyl jasmonate for the enhancement of selected phenolic acids accumulation. Three phenolic acids, rosmarinic acid (RA), chlorogenic acid (CGA) and caffeic acid (CA), were detected by HPLC-DAD in those cultures. The sum of their content in the dry material was found to be higher in the shoot culture (3.95 mg g -1 ), root culture (7.05 mg g -1 ), callus (6.20 mg g -1 ) and cell suspension (2.04 mg g -1 ) than in the leaves (1.87 mg g -1 ) and roots (0.76 mg g -1 ) of intact plants. The major compound of in vitro cultures was always rosmarinic acid. The content of RA could be increased approximately threefold (16.24 mg g -1 ) in the callus culture and approximately twofold (3.91 mg g -1 ) in the cell suspension culture by elicitation with 100 lM methyl jasmonate (MeJA). The higher concentration of sucrose (S) in the medium (5, 6 %) led to over a twofold increase of CGA content in the callus culture (2.54 mg g -1 ).The three mentioned phenolic acids have been found in E. planum undifferentiated and differentiated in vitro cultures for the first time.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Accumulation of rosmarinic, chlorogenic and caffeic acids in in vitro cultures of Eryngium planum L.

Kikowska

Budzianowski

Krawczyk³

et al. 2012

Acta Physiol Plant

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“…It is an ester of caffeic acid (hydroxycinnamic acid). 32 Rosemary's reported pharmacological actions have been linked to its major chemical constituents including rosmarinic acid. 33 In rosemary leaf, total hydroxycinnamic acid derivatives must not be less than (3 g%) expressed as rosmarinic acid.…”

Section: Discussionmentioning

confidence: 99%

Designing monographs for Rosmarinus officinalis L. and Lavandula angustifolia L.: Two Lebanese species with significant medicinal potentials

Koleilat¹,

Raafat²,

El-Lakany³

et al. 2017

Phcog J

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Introduction:The world health organization recommends validating medicinal plants to ensure safety and efficacy. Lavandula is valued for the production of essential oil used in aromatherapy. Rosmarinus is known for its folk use as anti-oxidant and antidiabetic. This study aims to design monographs for Rosmarinus officinalis (Linn.) and Lavandula angustifolia (Linn.) cultivated, in conditions similar to their natural habitat, at Beirut Arab University botanical garden. Also screening the antioxidant activity of both plants, and assessing the antidiabetic effect of R. officinalis (Linn.). Methods: macroscopic and microscopic examination, hydrodistillation to obtain essential oils (EOs), thin layer chromatography, Gas chromatography-Mass spectrometry, and physiochemical properties of the EOs were determined. The antioxidant effect of the EOs is determined by DPPH assay. The antidiabetic effect of Rosemary EO is investigated using alloxan-induced diabetic mice. Results: the qualities of studied species are in agreement with the standards described in WHO monographs and in the British pharmacopeia. Composition of the EO produced from either Rosemary (REO) or Lavender (LEO) collected at different months showed differences. The EO of both showed significant antioxidant effects in DPPH assay (p<0.05). In vivo investigation of the antidiabetic effect of REO showed a significant antidiabetic effect in diabetic mouse model (p<0.05). Conclusion: both plant species and their EOs fulfilled most of standards specified by the British Pharmacopeia 2013. Rosemary collected in April (Spring) showed the best antioxidant activity. Lavender collected in September (Early Fall) showed the best antioxidant activity. REO revealed significant lowering in blood glucose level at the dose of 110 mg/kg.

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“…It is also found in species of the Boraginaceae and in some fern and hornwort species (14). The major problem in their use is the plant-to-plant variability of RA.…”

Section: Discussionmentioning

confidence: 99%

A new validated high-performance liquid chromatography method for standardization of rosmarinic acid in Salvia extracts

Ghanadian¹,

Shamaeezadeh²,

Mohammadi³

et al. 2017

J Herbmed Pharmacol

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In the present study, a new validated HPLC method was developed which is suitable for analysis of rosmarinic acid and standardization of Labiateae family plants like Salvia, Melissa, Origanum, Lavandula, Rosmarinus, Thymus, Zataria, Mentha, Perovskia, Zhumeria, and Satureja species. Please cite this paper as: Ghanadian M Introduction:Tea bags or infuses of Salvia species from Lamiaceae family are traditionally used for the treatment of cough, and throat inflammations. They are known for antioxidant properties mainly related to the presence of rosmarinic acid (RA). Therefore it is necessary to develop a reliable analytical method for RA assay for standardization of Salvia species and also other plants containing RA like Melissa, Origanum, Lavandula, Rosmarinus, Thymus, Zataria, Mentha, Perovskia, Zhumeria, and Satureja species. In this study using a suitable extraction method by removing unwanted components present in crude methanol extract, phenolic content containing RA was extracted from dry powders of six Salvia species. Then, a suitable high-performance liquid chromatographic (HPLC) method was optimized for quantification of RA in Salvia species. Methods: HPLC analysis was done on a Waters system, equipped with 515 HPLC pump and waters 2487 dual wavelength absorbance detector. The column was a Nova-Pak C18 (3.9 × 150 mm), and Millenium software was used for the determination of the compounds and processing the data. The method was validated according to USP 32 requirements. Results: Among the investigated 6 species, S. virgata was the richest in RA level, demonstrating 3.50 ± 0.12 mg/g, followed by S. sclarea and S. chloroleuca showing 1.65 ± 0.08 and 1.65 ± 0.21 mg/g. S. ceratophylla with 0.10 ± 0.01 mg/g of RA in dried plant powder was the poorest. Conclusion:The validated HPLC method allows determination of amounts as low as 2.5 µg/ mL of RA and linearity in the ranges of 2.5-25 µg/mL and 100-600 µg/mL, which is suitable for standardization of Salvia species in traditional and pharmaceutical formulations.

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Evolution of rosmarinic acid biosynthesis

Cited by 276 publications

References 96 publications

Accumulation of rosmarinic, chlorogenic and caffeic acids in in vitro cultures of Eryngium planum L.

Accumulation of rosmarinic, chlorogenic and caffeic acids in in vitro cultures of Eryngium planum L.

Designing monographs for Rosmarinus officinalis L. and Lavandula angustifolia L.: Two Lebanese species with significant medicinal potentials

A new validated high-performance liquid chromatography method for standardization of rosmarinic acid in Salvia extracts

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