Evolution of systemic therapy of advanced hepatocellular carcinoma

Abstract

year, the iMELD still had the highest AUC (0.783), the difference between the iMELD and MELD was statistically significant (P < 0.05). Survival curves showed that the three new models were all clearly discriminated the patients who survived or died in short-term as well as intermediate-term (P < 0.001 INTRODUCTIONThe model for end-stage liver disease (MELD) was developed as a prognostic model of short-term mortality in patients with cirrhosis treated with transjugular intrahepatic portosystemic shunt (TIPS) [1] . The scoring system has been widely applied in recent years and shown to predict mortality across a broad spectrum of liver diseases in most studies. But, there is not any parameter correlated with complications of cirrhosis in this formula. Its ability of prognosis is decreased. Some studies have indicated that serum sodium is the independent predictor of mortality in patients with cirrhosis [2,3] . And the incorporation of Na into the MELD may enhance its prognostic accuracy [4,5] . Then some scholars had successively introduced three new mathematical equations based on both MELD and Na, Abstract AIM: To investigate the prognostic value of the model for end-stage liver disease (MELD) and three new MELD-based models combination with serum sodium in decompensated cirrhosis patients-the MELD with the incorporation of serum sodium (MELD-Na), the integrated MELD (iMELD), and the MELD to sodium (MESO) index. METHODS: A total of 166 patients with decompensated cirrhosis were enrolled into the study. MELD, MELDNa, iMELD and MESO scores were calculated for each patient following the original formula on the first day of admission. All patients were followed up at least 1 year. The predictive prognosis related with the four models was determined by the area under the receiver operating characteristic curve (AUC) of the four parameters. Kaplan-Meier survival curves were made using the cut-offs identified by means of receiver operating characteristic (ROC). RESULTS: Out of 166 patients, 38 patients with significantly higher MELD-Na (28.84 ± 2.43 vs 14.72 ± 0.60), iMELD (49.04 ± 1.72 vs 35.52 ± 0.67), MESO scores (1.59 ± 0.82 vs 0.99 ± 0.42) compared to the survivors died within 3 mo (P < 0.001). Of 166 patients, 75 with markedly higher MELD-Na (23.01 ± 1.51 vs 13.78 ± 0.69), iMELD (44.06 ± 1.19 vs 34.12 ± 0.69), MESO scores (1.37 ± 0.70 vs 0.93 ± 0.40) than the survivors died within 1 year (P < 0.001). At 3 mo of enrollment, the iMELD had the highest AUC (0.841), and was followed by the MELD-Na (0.766), MESO (0.723), all larger than MELD (0.773); At 1

Serum lipids as an indicator for the alteration of liver function in patients with hepatitis B

“…MELD score was calculated by using the base line characteristics through “Online UNOS MELD calculator” [ 13 ]: …”

Sensor for Nitrophenol Based on a Fluorescent Molecular Clip

“…Glycolurilas the essential component of Nolte’s molecular clips, Rebek’s capsules, and the cucurbit[ n ]uril family of macrocycleshas become a popular building block for the preparation of new host systems . Of particular relevance to the work reported here are the reports by Nolte on the use of U-shaped glycoluril-based molecular clips as receptors for 1,3-dihydroxybenzene derivatives whose complexes benefit from Ar−OH···OC H-bonds, π−π stacking interactions, and a cavity effect .…”

Metastable oxidation states of tetrathiafulvalenes on the surface of liposomes

“…Dimer formation of the TTF radical cation is common in the solid state and can be observed at low temperatures in a concentrated TTF solution, 29 but only a few examples of the characterization of (TTF + c) 2 at room temperature in a dilute solution are known up to date. They are limited to bis-TTF derivatives with two closely-aligned TTF units, such as bis-TTF molecular clips 30 and TTF-substituted calix [4]arenes, 31 to supramolecular architectures in which dimers (TTF + c) 2 are stabilized in the framework of [3]cantenane, 32 and to inclusion complex of two TTF + c radical cations within the cavity of cucubit [8]uril. 33 In all these examples, dimer stabilization was achieved by localization of two TTF groups in close proximity.…”