Evolution of T1 Relaxation, ADC, and Fractional Anisotropy during Early Brain Maturation: A Serial Imaging Study on Preterm Infants

Schneider, J; Kober, Tobias; Graz, Myriam Bickle; Meuli, Reto; Hüppi, Petra Susan; Hagmann, Patric; Truttmann, Anita C.

doi:10.3174/ajnr.a4510

Cited by 64 publications

(61 citation statements)

References 37 publications

(48 reference statements)

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“…For example, over the years several studies have shown that even intra-cortical myelin can be probed through the T1-shortening caused by myelin, giving rise to MR signal differences along the cortical rim [127–129]. In white matter fibres, T1 undergoes profound changes in development [130]. Recently, it was shown in adults that variations in T1 can be explained in terms of a combination of other quantitative MR parameters, regardless whether grey or white matter areas are considered [14].…”

Section: Discussionmentioning

confidence: 99%

Assessing White Matter Microstructure in Brain Regions with Different Myelin Architecture Using MRI

et al. 2016

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ObjectiveWe investigate how known differences in myelin architecture between regions along the cortico-spinal tract and frontal white matter (WM) in 19 healthy adolescents are reflected in several quantitative MRI parameters that have been proposed to non-invasively probe WM microstructure. In a clinically feasible scan time, both conventional imaging sequences as well as microstructural MRI parameters were assessed in order to quantitatively characterise WM regions that are known to differ in the thickness of their myelin sheaths, and in the presence of crossing or parallel fibre organisation.ResultsWe found that diffusion imaging, MR spectroscopy (MRS), myelin water fraction (MWF), Magnetization Transfer Imaging, and Quantitative Susceptibility Mapping were myelin-sensitive in different ways, giving complementary information for characterising WM microstructure with different underlying fibre architecture. From the diffusion parameters, neurite density (NODDI) was found to be more sensitive than fractional anisotropy (FA), underlining the limitation of FA in WM crossing fibre regions. In terms of sensitivity to different myelin content, we found that MWF, the mean diffusivity and chemical-shift imaging based MRS yielded the best discrimination between areas.ConclusionMultimodal assessment of WM microstructure was possible within clinically feasible scan times using a broad combination of quantitative microstructural MRI sequences. By assessing new microstructural WM parameters we were able to provide normative data and discuss their interpretation in regions with different myelin architecture, as well as their possible application as biomarker for WM disorders.

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Section: Discussionmentioning

confidence: 99%

Assessing White Matter Microstructure in Brain Regions with Different Myelin Architecture Using MRI

et al. 2016

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“…Neonatal scans from 9 very prematurely born infants (4 males, mean gestational age: 27.3 weeks ± 1.0 day) acquired at term equivalent age (TEA, mean age at scan 41.0 weeks ± 2.0 days) were selected from a prospective cohort of neonates born before 30 weeks of gestation conducted between February 2011 and May 2013 in the level III neonatology unit at the University Hospital of Lausanne, Switzerland [40]. This cohort included solely children considered as ‘cerebral low-risk’, meaning that they showed no evidence for severe intraventricular haemorrhage grade III-IV and/or parenchymal haemorrhagic infarction, no high grade periventricular leucomalacia, no congenital malformations or genetic abnormalities and had normal neurological assessment at TEA according to the Hammersmith Neonatal Neurologic Examination from [41].…”

Section: Methodsmentioning

confidence: 99%

“…Recently developed MRI sequences sensitive to microstructural changes in the cerebral cortex and the WM (diffusion tensor, T1-mapping) have emerged as sensitive assays to study developmental related changes in human brain [36–40]. Our study is designed in two parts.…”

Section: Introductionmentioning

confidence: 99%

Exploring the role of white matter connectivity in cortex maturation

et al. 2017

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The maturation of the cortical gray matter (GM) and white matter (WM) are described as sequential processes following multiple, but distinct rules. However, neither the mechanisms driving brain maturation processes, nor the relationship between GM and WM maturation are well understood. Here we use connectomics and two MRI measures reflecting maturation related changes in cerebral microstructure, namely the Apparent Diffusion Coefficient (ADC) and the T1 relaxation time (T1), to study brain development. We report that the advancement of GM and WM maturation are inter-related and depend on the underlying brain connectivity architecture. Particularly, GM regions and their incident WM connections show corresponding maturation levels, which is also observed for GM regions connected through a WM tract. Based on these observations, we propose a simple computational model supporting a key role for the connectome in propagating maturation signals sequentially from external stimuli, through primary sensory structures to higher order functional cortices.

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“…Our findings suggest that even in the absence of structural brain injury, the developmental trajectory of the preterm brain is altered over the third trimester. Evidence of clinical 4 .01 * 14.17 ± 1.6 [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] 13.91 ± 2.7 [8][9][10][11][12][13][14][15][16][17][18][19][20] .66…”

Section: Discussionmentioning

confidence: 99%

Third Trimester Brain Growth in Preterm Infants Compared With In Utero Healthy Fetuses

et al. 2016

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BACKGROUND AND OBJECTIVES:Compared with term infants, preterm infants have impaired brain development at term-equivalent age, even in the absence of structural brain injury. However, details regarding the onset and progression of impaired preterm brain development over the third trimester are unknown. Our primary objective was to compare third-trimester brain volumes and brain growth trajectories in ex utero preterm infants without structural brain injury and in healthy in utero fetuses. As a secondary objective, we examined risk factors associated with brain volumes in preterm infants over the thirdtrimester postconception.

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Evolution of T1 Relaxation, ADC, and Fractional Anisotropy during Early Brain Maturation: A Serial Imaging Study on Preterm Infants

Cited by 64 publications

References 37 publications

Assessing White Matter Microstructure in Brain Regions with Different Myelin Architecture Using MRI

Assessing White Matter Microstructure in Brain Regions with Different Myelin Architecture Using MRI

Exploring the role of white matter connectivity in cortex maturation

Third Trimester Brain Growth in Preterm Infants Compared With In Utero Healthy Fetuses

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