Evolution of Tc-99m in diagnostic radiopharmaceuticals

Banerjee, Sharmila; Pillai, M.R.A.; Ramamoorthy, N.

doi:10.1053/snuc.2001.26205

Cited by 217 publications

(161 citation statements)

References 132 publications

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“…Myocardial perfusion imaging with radiotracers is an integral component of the clinical evaluation of patients with known or suspected coronary artery disease (26)(27)(28)(29). Since the early 1980s, intensive research efforts have been directed towards development of cationic 99m Tc complex radiotracers for heart imaging (26,27).…”

Section: Discussionmentioning

confidence: 99%

Impact of Bidentate Chelators on Lipophilicity, Stability, and Biodistribution Characteristics of Cationic ^99mTc-Nitrido Complexes

Kim

Hsieh

et al. 2007

Bioconjugate Chem.

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This report describes synthesis and evaluation of novel cationic 99m Tc-nitrido complexes, [ 99m TcN (L)(PNP)] + (L = ma, ema, tma, etma and mpo; PNP = PNP5, PNP6 and L6), as potential radiotracers for heart imaging. is of particular interest due to its high initial heart uptake (1.81±0.35 %ID/g at 5 min postinjection), and long myocardial retention (1.99±0.47 %ID/g at 120 min postinjection). The heart/liver ratio of [ 99m TcN(etma)(PNP5)] + (6.06±1.48) at 30 min postinjection is almost identical that of 99m TcN-DBODC5 (6.01±1.45), and is >2 times better than that of 99m Tcsestamibi (2.90±0.22). Results from metabolism studies show that [ 99m TcN(etma)(PNP5)] + has no significant metabolism in the urine; but it does show significant metabolism in feces samples at 120 min postinjection. Planar imaging studies suggest that [ 99m TcN(etma)(PNP5)] + might be able to give clinically useful images of the heart as early as 30 min postinjection. [ 99m TcN(etma)(PNP5)] + is a very promising candidate for more pre-clinical evaluations in various animal models.

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Section: Discussionmentioning

confidence: 99%

Impact of Bidentate Chelators on Lipophilicity, Stability, and Biodistribution Characteristics of Cationic ^99mTc-Nitrido Complexes

Kim

Hsieh

et al. 2007

Bioconjugate Chem.

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“…99m Tc-etarfolatide takes advantage of the more optimal SPECT imaging characteristics of technetium (half-life of 6 h and 140-keV photon) and has been evaluated in several clinical trials (1,3,11,13,16).…”

Section: M Tc-etarfolatide Characteristicsmentioning

confidence: 99%

Imaging the Folate Receptor on Cancer Cells with ^99mTc-Etarfolatide: Properties, Clinical Use, and Future Potential of Folate Receptor Imaging

et al. 2014

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Folate receptor (FR) can be used as a therapeutic target because of its expression on different epithelial cancers, such as ovarian, nonsmall cell lung, endometrial, and breast cancer. Assessing FR expression in tumors may help to identify patients who can benefit from FR-targeted therapeutics, such as vintafolide and farletuzumab. Different methods exist to detect FR expression. Tissue sampling has limited clinical utility, mainly because it requires an invasive procedure. 99m Tc-etarfolatide, a 99m Tc-labeled folate conjugate, is in latephase trials in Europe and the United States. It allows noninvasive, whole-body imaging of the FR. This review focuses on this FRimaging agent and how it may be used to direct FR-targeted therapy.

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“…The measurement was carried out every 5th day for a period of 30 days (Banerjee et al, 2001;Kumar et al, 2014b) and % reduction in tumor volume (R) was calculated using following formula Where, Vc and Vt are tumor volume of EAC control group and treated group respectively. Volume was determined by general formula of sphere as where, r1 and r2 are radius from two perpendicular axis of tumor.…”

Section: %Reduction In Tumor Volumementioning

confidence: 99%

In vitro and in vivo evaluation of antitumor activity of methanolic extract of Argyreia nervosa leaves on Ehrlich ascites carcinoma

Sharma¹,

Dhamija²,

Kumar³

et al. 2015

Bangladesh J Pharmacol

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The herb of importance like Argyreia nervosa has shown wide range of pharmacological activities. Its methanolic extract of A. nervosa has been explored against Ehrlich ascites carcinoma (EAC) induced liquid and solid tumor in mice. Liquid and solid tumors were induced by intraperitoneal and subcutaneous transplantation of EAC cells in Balb/C mice. Significant and dose dependant results are observed when the mice are sacrificed on 15th day for estimation of tumor proliferation, hematological, biochemical and hepatic antioxidant parameters. Mean survival time (days) was increased to 36.5 from 20.5 extract treated mice. The extract also showed a decrease (p<0.001) in body weight and percentage reduction in tumor volume respectively when it was evaluated in solid tumor induced mice for a period of 30 days. From the result it was concluded that the extract has as a potent antitumor activity and that is comparable to 5-fluorouracil.

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Evolution of Tc-99m in diagnostic radiopharmaceuticals

Cited by 217 publications

References 132 publications

Impact of Bidentate Chelators on Lipophilicity, Stability, and Biodistribution Characteristics of Cationic ^99mTc-Nitrido Complexes

Impact of Bidentate Chelators on Lipophilicity, Stability, and Biodistribution Characteristics of Cationic ^99mTc-Nitrido Complexes

Imaging the Folate Receptor on Cancer Cells with ^99mTc-Etarfolatide: Properties, Clinical Use, and Future Potential of Folate Receptor Imaging

<i>In vitro</i> and <i>in vivo</i> evaluation of antitumor activity of methanolic extract of <i>Argyreia nervosa</i> leaves on Ehrlich ascites carcinoma

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Evolution of Tc-99m in diagnostic radiopharmaceuticals

Cited by 217 publications

References 132 publications

Impact of Bidentate Chelators on Lipophilicity, Stability, and Biodistribution Characteristics of Cationic 99mTc-Nitrido Complexes

Impact of Bidentate Chelators on Lipophilicity, Stability, and Biodistribution Characteristics of Cationic 99mTc-Nitrido Complexes

Imaging the Folate Receptor on Cancer Cells with 99mTc-Etarfolatide: Properties, Clinical Use, and Future Potential of Folate Receptor Imaging

<i>In vitro</i> and <i>in vivo</i> evaluation of antitumor activity of methanolic extract of <i>Argyreia nervosa</i> leaves on Ehrlich ascites carcinoma

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Impact of Bidentate Chelators on Lipophilicity, Stability, and Biodistribution Characteristics of Cationic ^99mTc-Nitrido Complexes

Impact of Bidentate Chelators on Lipophilicity, Stability, and Biodistribution Characteristics of Cationic ^99mTc-Nitrido Complexes

Imaging the Folate Receptor on Cancer Cells with ^99mTc-Etarfolatide: Properties, Clinical Use, and Future Potential of Folate Receptor Imaging