In the context of the development of digital economy and the widespread adoption of digital technologies in various fields of life and activities of modern society, the digital transformation of the education system and research activities of the country's population becomes relevant. Universities, as the main links in this system, are entering a new stage, a model of their development in which the digitalization of all its activity fields plays a dominant role. The digital transformation of universities involves a comprehensive transformation of all the basic activities of the university and the infrastructure corresponding to the implementation of these types of activities. Due to the rapid development and widespread use of digital technology, the universities have gained new perspectives and opportunities to improve the quality and convenience of the educational process. Due to the proliferation and widespread use of massive open online courses, the universities have become able to compete globally. The widespread introduction of digital technology in the main areas of university activity is the main condition for accelerating innovative transformations in the preparation of bachelors and masters. Digital transformation is becoming a key mechanism for creating a university’s competitive advantage in the global educational space. The purpose of this work is to investigate methodological approaches to the digital transformation of the main types of university activities: educational, research and entrepreneurial.