Evolutionary history of hepatitis B virus genotype H

Wolf, Jonas Michel; Pereira, Vagner Reinaldo Zingalli Bueno; Simon, Daniel; Lunge, Vagner Ricardo

doi:10.1002/jmv.26463

Cited by 6 publications

(10 citation statements)

References 19 publications

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“…3,24 In a recent study, it was identified that the common ancestor of HBV-H dates back to 1933 in North America, with an increase in the number of infections between the 1980s and 2000s. 34 These findings are similar to those observed in the present study and indicate that the transmission routes of these genotypes can be similar, especially in high-risk groups (MSM and users of illicit drugs). 3,27,33 The fact that HBV-G spread in the 1980s to the 1990s when HBV vaccines were available and HBV detection tests were largely used in many countries is also concerning.…”

Section: Discussionsupporting

confidence: 91%

“…Mexico is the country with the highest prevalence of HBV‐G and HBV‐H worldwide and both are associated with hidden infection 3,24 . In a recent study, it was identified that the common ancestor of HBV‐H dates back to 1933 in North America, with an increase in the number of infections between the 1980s and 2000s 34 . These findings are similar to those observed in the present study and indicate that the transmission routes of these genotypes can be similar, especially in high‐risk groups (MSM and users of illicit drugs) 3,27,33 …”

Section: Discussionmentioning

confidence: 99%

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Temporal evolution and global spread of hepatitis B virus genotype G

Wolf

Carli

Pereira

et al. 2020

Journal of Viral Hepatitis

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Hepatitis B virus (HBV) is one of the main causes of liver disease infecting around 300 million people worldwide. It has also a very ancient origin with an evolutionary history related to the human species since its dispersion around the world. 1,2 Current classification divides HBV into ten genotypes (from A to J), most of them with sub-genotypes, according to their genetic divergences. 1 Genotypes A, D and F are frequently detected in Western countries, while B and C are more prevalent in the Far Eastern World. The remaining genotypes usually have a low prevalence and are detected in very specific geographic regions: E in Africa, H in Central America, I and J in Asia. 3,4 HBV genotype G (HBV-G) is infrequent with a low worldwide prevalence (0.5%). However, it has been detected in different and distant countries (Argentina, Brazil, Mexico, Netherlands, South Africa, United States, Venezuela) suggesting some specific epidemiological dissemination route. Importantly, most infections by this genotype were reported in America (73.5%), followed by Europe (23.7%) and other continents of the world (2.5%). 3

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Temporal evolution and global spread of hepatitis B virus genotype G

Wolf

Carli

Pereira

et al. 2020

Journal of Viral Hepatitis

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“…It was also consistent with the results of Kocher et al, in 2021. However, it differs from that reported by Wolf et al (2021) , who calculated an age for the genotype H of 87 YBP. However, their analysis described the contemporary spread of genotype H to other countries.…”

Section: Discussioncontrasting

confidence: 89%

Tracing the evolutionary history of hepatitis B virus genotype H endemic to Mexico

et al. 2023

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Hepatitis B virus (HBV) spreads efficiently among all human populations worldwide. HBV is classified into ten genotypes (A to J) with their geographic distribution and clinical features. In Mexico, HBV genotype H is the leading cause of hepatitis B and has been detected in indigenous populations, suggesting that HBV genotype H may be native to Mexico. However, little is known about the evolutionary history of HBV genotype H. Thus, we aimed to determine the age of HBV genotype H in Mexico using molecular dating techniques. Ninety-two HBV sequences of the reverse transcriptase (RT) domain of the polymerase gene (~1,251 bp) were analyzed; 48 were genotype H, 43 were genotype F, and the oldest HBV sequence from America was included as the root. All sequences were aligned, and the most recent common ancestor (TMRCA) time was calculated using the Bayesian Skyline Evolutionary Analysis. Our results estimate a TMRCA for the genotype H in Mexico of 2070.9 (667.5–4489.2) years before the present (YBP). We identified four major diversification events in genotype H, named H1, H2, H3, and H4. The TMRCA of H1 was 1213.0 (253.3–2638.3) YBP, followed by H2 1175.5 (557.5–2424.2) YBP, H3 949.6 (279.3–2105.0) YBP, and H4 1230.5 (336.3, 2756.7) YBP. We estimated that genotype H diverged from its sister genotype F around 8140.8 (1867.5–18012.8) YBP. In conclusion, this study found that genotype H in Mexico has an estimated age of 2070.9 (667.5–4489.2) YBP and has experienced at least four major diversification events since then.

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“…In addition, different clades have been described for subgenotype F1 (F1a, b, c, and d) and F2 (F2a and b). Two clades have been proposed for HBV genotype H [ 42 ].…”

Section: The American Genotypes F and Hmentioning

confidence: 99%

The Hepatitis B Virus Genotypes E to J: The Overlooked Genotypes

et al. 2023

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Hepatitis B virus (HBV) genotypes E to J are understudied genotypes. Genotype E is found almost exclusively in West Africa. Genotypes F and H are found in America and are rare in other parts of the world. The distribution of genotype G is not completely known. Genotypes I and J are found in Asia and probably result from recombination events with other genotypes. The number of reported sequences for HBV genotypes E to J is small compared to other genotypes, which could impact phylogenetic and pairwise distance analyses. Genotype F is the most divergent of the HBV genotypes and is subdivided into six subgenotypes F1 to F6. Genotype E may be a recent genotype circulating almost exclusively in sub-Saharan Africa. Genotype J is a putative genotype originating from a single Japanese patient. The paucity of data from sub-Saharan Africa and Latin America is due to the under-representation of these regions in clinical and research cohorts. The purpose of this review is to highlight the need for further research on HBV genotypes E to J, which appear to be overlooked genotypes.

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Evolutionary history of hepatitis B virus genotype H

Cited by 6 publications

References 19 publications

Temporal evolution and global spread of hepatitis B virus genotype G

Temporal evolution and global spread of hepatitis B virus genotype G

Tracing the evolutionary history of hepatitis B virus genotype H endemic to Mexico

The Hepatitis B Virus Genotypes E to J: The Overlooked Genotypes

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