Evolving Role of Novel Quantitative PET Techniques to Detect Radiation-Induced Complications

Dreyfuss, Alexandra D.; Jahangiri, Pegah; Simone, Charles B.; Alavi, Abass

doi:10.1016/j.cpet.2019.08.003

Cited by 2 publications

(1 citation statement)

References 91 publications

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“…Future directions of research include the role of FDG PET/CT in the detection and quantification of radiation-induced lung injury, with volumetric PET parameters serving as potential biomarkers for assessing lung inflammation after RT. Global lung FDG uptake after RT for patients with locally advanced NSCLC can be quantified by subtracting the tumor uptake from the total lung FDG uptake using volume-based quantitative FDG PET/CT parameters such as global lung glycolysis, total lesion glycolysis, and lung parenchyma mean standardized uptake value [37].…”

Section: Positron Emission Tomography/computed Tomographymentioning

confidence: 99%

Spectrum of Imaging Patterns of Lung Cancer following Radiation Therapy

Strange,

Erasmus,

Ahuja

et al. 2023

Diagnostics

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Radiation therapy using conventional or newer high-precision dose techniques, including three-dimensional conformal radiotherapy, intensity-modulated radiation therapy, stereotactic body radiation therapy, four-dimensional conformational radiotherapy, and proton therapy, is an important component of treating patients with lung cancer. Knowledge of the radiation technique used and the expected temporal evolution of radiation-induced lung injury, as well as patient-specific parameters such as previous radiotherapy, concurrent chemoradiotherapy, or immunotherapy, is important in image interpretation. This review discusses factors that affect the development and severity of radiation-induced lung injury and its radiological manifestations, as well as the differences between conventional and high-precision dose radiotherapy techniques.

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Section: Positron Emission Tomography/computed Tomographymentioning

confidence: 99%

Spectrum of Imaging Patterns of Lung Cancer following Radiation Therapy

Strange,

Erasmus,

Ahuja

et al. 2023

Diagnostics

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The emerging role of positron emission tomography (PET) in the management of photon radiotherapy-induced vasculitis in head and neck cancer patients

Delman

Griffin

Werner

et al. 2023

Clin Transl Imaging

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Purpose While radiotherapy (RT) for head and neck cancer (HNC) has made recent strides, RT-induced vasculitis continues to adversely affect long-term patient outcomes. Guidelines for managing this complication remain scarce, supporting the need for a sensitive imaging modality in post-treatment evaluations. In this review, we discuss the current literature regarding 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and 18F-sodium fluoride (NaF-PET) in evaluating RT-induced vasculitis in HNC patients, highlighting several arenas of evolving clinical significance: (1) early recognition and standardized evaluation of RT-induced vasculitis, and (2) potential for a multifaceted diagnostic tool to stratify cardiovascular risk in HNC patients. Methods Numerous databases, including, but not limited to, Google Scholar and PubMed, were utilized to compile a body of literature regarding PET imaging of RT-induced vasculitis in HNC and related malignancies. Results Multiple studies have established the clinical capabilities of FDG-PET/computed tomography (FDG-PET/CT) for detection and management of RT-induced vasculitis in HNC patients, while NaF-PET/CT remains under investigation. Inflammatory vascular stages may be best analyzed by FDG-PET/CT, while vascular microcalcification and atherosclerotic disease may be supplementally assessed by the unique properties of NaF-PET/CT. With these modalities detecting primary stages of more detrimental vascular complications, PET imaging may carry several advantages over conventional, structural techniques. Conclusion FDG-PET/CT and NaF-PET/CT hold significant potential as preliminary diagnostic tools in monitoring early inflammation and atherosclerotic plaque development, warranting further research and attention. Applying these techniques in this context may foster proactive and consistent assessments of RT-induced vasculitis in HNC patients, mitigating potential cardiovascular risks through better-informed treatment decisions.

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Evolving Role of Novel Quantitative PET Techniques to Detect Radiation-Induced Complications

Cited by 2 publications

References 91 publications

Spectrum of Imaging Patterns of Lung Cancer following Radiation Therapy

Spectrum of Imaging Patterns of Lung Cancer following Radiation Therapy

The emerging role of positron emission tomography (PET) in the management of photon radiotherapy-induced vasculitis in head and neck cancer patients

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