Ewing Sarcoma of the Kidney: A Rare Entity

Almeida, Maria Fernanda Arruda; Patnana, Madhavi; Korivi, Brinda Rao; Kalhor, Neda; Marcal, Leonardo P.

doi:10.1155/2014/283902

Cited by 23 publications

(26 citation statements)

References 14 publications

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“…Primary ESFT of the kidney is rarely reported. 33 - 41 However, in the present series, involvement of kidney was seen in 7 (median age of presentation: 30 years) patients. Further ESFTs in bladder and prostate noted in this cohort were rarely reported.…”

Section: Discussioncontrasting

confidence: 62%

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Murthy

Challa

Raju

et al. 2020

Clin Med�Insights�Pathol

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Introduction: The diagnosis of Ewing sarcoma family of tumours (ESFT) is challenging, especially in adults and in extra-skeletal or visceral location. Several morphologic mimics with varied treatment options and prognosis confer diagnostic dilemmas. Application of ancillary diagnostic modalities in surgical pathology in clinical routine has enabled accurate diagnosis of ESFT in bone, soft tissues, and viscera. Aim: The study aims to assess the clinicopathological features including molecular test results of ESFT with emphasis on sex, age, and location, especially extra-skeletal soft tissue and visceral location. Material and Methods: Data of clinicopathological, molecular tests (wherever performed), diagnosis rendered in 302 ESFT over a decade from our centre were reviewed. Statistical comparison of skeletal and extra-skeletal tumours with reference to age and sex was done using SPSS package. The P value of <.05 was considered significant. Results: The cohort included 302 ESFTs with 49% skeletal and 51% extra-skeletal tumours. Thigh was most common site among skeletal tumours; chest wall, paraspinal location, and retroperitoneum among soft tissues (39.4%); and kidney, ovary, and cervix among visceral tumours (11.3%). Fluorescence in situ hybridisation for EWSR1 gene rearrangement was positive in 54 patients and reverse-transcriptase polymerase chain reaction in 19 patients. Predominance of male sex, younger age and location in extremities among skeletal tumours and lack of gender predilection, higher age and axial location in extra-skeletal tumours were noted, which were statistically significant. Molecular tests were performed more frequently in extra-skeletal tumours, especially in visceral tumours to establish the diagnosis. Conclusions: The study showed statistically significant differences in the age, sex, and location between skeletal and extra-skeletal ESFT. The increased percentage of extra-skeletal tumours especially in viscera was attributed to the increased awareness and availability of ancillary techniques.

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Section: Discussioncontrasting

confidence: 62%

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Murthy

Challa

Raju

et al. 2020

Clin Med�Insights�Pathol

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“…The size of the tumor at the moment of diagnosis varies in the literature from 5.5 to 23 cm. The CT and MRI characteristics can also be found in the case of other types of renal tumor [ 4 ]. Most of the renal masses incidentally discovered are benign renal cysts but the differential diagnosis should also be made with abscesses, lymphomas, metastases from a distant primary lesion, oncocytomas, renal adenomas, sarcomas, Wilms tumors, and renal cell carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…Ewing's sarcomas have obvious metastases at the time of diagnosis in 20–25% of the cases, being the main indicator of prognosis. Furthermore, after local therapy, 80–90% of the cases develop in time systemic relapse, suggesting that the metastases had been present subclinically at the moment of diagnosis [ 4 ]. The most common sites of secondary determinations of Ewing's sarcoma are the liver, lungs, and the skeletal system.…”

Section: Discussionmentioning

confidence: 99%

Ewing’s Sarcoma of the Kidney Complicated by a Wunderlich Syndrome

Manescu

Froment³

et al. 2015

Case Reports in Urology

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The Wunderlich syndrome found after the rupture of primitive renal Ewing's sarcoma is not a situation that we find often in everyday practice. The clinical findings are not specific, which is why the differential diagnosis must be made with a multitude of benign and malignant renal masses until the correct diagnosis can be made by the pathologist. The CT and MRI images are not characteristic. One treatment option is the multidisciplinary approach; however, the prognosis remains poor for patients with metastatic disease.

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“…Although radiological and clinical features may suggest PNET in a large renal mass in a relatively young patient, definitive diagnosis requires detailed pathological examination including immunohistochemical and cytogenetical analyses [6,9]. …”

Section: Discussionmentioning

confidence: 99%

“…However, despite aggressive treatment, patients with metastatic disease have poor prognosis and low overall survival rates [9]. …”

Section: Discussionmentioning

confidence: 99%

CT and MRI Findings in a Rare Case of Renal Primitive Neuroectodermal Tumor

et al. 2016

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SummaryBackgroundPrimary renal primitive neuroectodermal tumor/extraskeletal Ewing’s sarcoma (PNET/EES) is a very rare renal tumor.Case ReportWe report a case of primary renal PNET/EES of the kidney in an adult patient and describe its computed tomography and magnetic resonance imaging findings, including diffusion weighted images along with a review of the current medical literature.ConclusionsAlthough very rare, a relatively large renal mass which shows very infiltrative growth pattern on CT and MR imaging and striking diffusion restriction should raise the suspicion of a renal primitive neuroectodermal tumor, in a young adult.

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Ewing Sarcoma of the Kidney: A Rare Entity

Cited by 23 publications

References 14 publications

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Ewing Sarcoma With Emphasis on Extra-skeletal Ewing Sarcoma: A Decade’s Experience From a Single Centre in India

Ewing’s Sarcoma of the Kidney Complicated by a Wunderlich Syndrome

CT and MRI Findings in a Rare Case of Renal Primitive Neuroectodermal Tumor

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