Ex vivo and in vivo investigations of picroliv from Picrorhiza kurroa in an alcohol intoxication model in rats

Saraswat, Binduja; Visen, P. K. S.; Patnaik, G. K.; Dhawan, B. N.

doi:10.1016/s0378-8741(99)00007-0

Cited by 61 publications

(39 citation statements)

References 18 publications

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“…The findings from present study confirmed the experimental hepatocellular damage due to exposure of hepatotoxicants: PCM, CCl 4 and alcohol in wistar rats (Saraswat et al, 1999;Yanpallewar et al, 2002). However, pretreatment with PZ extract produced significant attenuation in toxic effects of experimental hepatic damage in a dose dependent manner and this…”

Section: Discussionsupporting

confidence: 86%

POSSIBLE MECHANISM OF <i>PLUMBAGO ZEYLANICA</i> IN PREVENTION OF HEPATIC DAMMAGE IN WISTAR RAT

Goyal¹

2012

American Journal of Pharmacology and Toxicology

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Plumbago zeylanica root has been used traditionally to treat various body ailments including liver diseases. The present study was designed to investigate the hepatoprotective effects of standardized methanolic extract of Plumbago zeylanica root on paracetamol, CCl 4 and alcohol induced hepatic injuries in rats and its possible mechanism(s) of hepatoprotection. Administration of hepatotoxicants like paracetamol (3 g kgto Wistar albino rats (180-240 g of either sex, n = 8) caused significant increase in serum ALT, AST, ALP and bilirubin; tissue lipid peroxidation, nitrite/nitrate, collagen; and decrease in tissue GSH and SOD levels. The liver histopathology revealed central vein dilation, infiltration and fatty degeneration in hepatotoxicant control groups. Pretreatment with methanolic extract of Plumbago zeylanica (100, 200 and 400 mg kg −1 ) and silymarin (50 mg kg −1 ) as standard significantly reversed these toxic changes dose dependently, as compared to hepatotoxicant control. The results in present study suggested that Plumbago zeylanica root possesses marked hepatoprotective potential through its oxidative, inflammatory and fibrotic effects against experimentally induced liver toxicity. These findings support and extend the rational basis for the use of this plant as hepatoprotective in traditional and folk-lore medicine.

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Section: Discussionsupporting

confidence: 86%

POSSIBLE MECHANISM OF <i>PLUMBAGO ZEYLANICA</i> IN PREVENTION OF HEPATIC DAMMAGE IN WISTAR RAT

Goyal¹

2012

American Journal of Pharmacology and Toxicology

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“…India, the abode of Ayurvedic system of medicine, assigns much importance to the pharmacological aspects of many plants. Hepatoprotective effect of some plants like Spirulina maxima [7] , Eclipta alba [8] , Boehmeria nivea [9] , Cichorium intybus [10] , and Picrorhiza kurroa [11] has been well established. Nearly 150 phytoconstituents from 101 plants have been claimed to possess liver protecting activity [12] .…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies

Ibrahim¹,

Khaja²,

Aara³

et al. 2008

WJG

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“…However, several studies suggest that some herbal plants such as Spirulina maxima (Torres -Durain et al, 1999), Eclipta alba (Saxena et al, 1993), Boehmeria nivea (Lin et al, 1998), Cichorium intybus (Zafar and Ali, 1998), Picrorhiza kurrooa (Saraswat et al, 1999), Trianthema decandra (Balamurugan and Muthusamy, 2008), and Phyllanthus niruri (Iqbal et al, 2007) etc. have hepatoprotective effects.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats

Thakare

Jain

Patil

et al. 2009

Bangladesh J Pharmacol

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In this animal model (Wistar rats of either sex), common bile duct was ligated for 28 days. Rats were treated for 28 days with methanol extract of Cocculus hirsutus. On day 29, blood and liver were collected for biochemical estimation and histopathological studies. Bile duct ligation produced liver fibrosis with generation of reactive oxygen species and induction of oxidative stress. Hence the different concentrations of methanolic extract of C. hirsutus were evaluated for in vivo glutathione reductase activity. On bile duct ligation the liver fibrosis was induced with significant rise in serum marker enzymes levels. The hydroxyproline accumulation caused by hydrophilic bile acids accompanied by elevated hepatic lipid peroxidation, and glutathione levels. Treatment with C. hirsutus extract decreased the elevated levels of serum marker enzymes showing hepatoprotection, which was further confirmed by histopathological results. Article Info

show abstract

Ex vivo and in vivo investigations of picroliv from Picrorhiza kurroa in an alcohol intoxication model in rats

Cited by 61 publications

References 18 publications

POSSIBLE MECHANISM OF <i>PLUMBAGO ZEYLANICA</i> IN PREVENTION OF HEPATIC DAMMAGE IN WISTAR RAT

POSSIBLE MECHANISM OF <i>PLUMBAGO ZEYLANICA</i> IN PREVENTION OF HEPATIC DAMMAGE IN WISTAR RAT

Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies

Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats

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