Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study

Pal, Rakhi; Venkataramana, N. K.; Jan, Majahar Jaan as Majahar; Bansal, Abhilash; Balaraju, Sudheer; Jaan, Majahar; Chandra, Ravi A.; Dixit, Ashish; Rauthan, Amit; Murgod, Uday; Totey, S.M.

doi:10.1080/14653240903253857

Cited by 58 publications

(84 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…48 MSC-based cellular therapy was also applied for the treatment of spinal cord injury in a pilot study. 49 Despite the numerous clinical trials being developed for MSC use in neurodegenerative disorders, a clear evidence of their neurogenic reparative potential, either through a trophic or an immunomodulatory effect, is lacking.…”

Section: Neurodegenerative Disordersmentioning

confidence: 99%

Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine?

Bernardo

Pagliara

Locatelli

2011

Bone Marrow Transplant

137

109

View full text Add to dashboard Cite

Because of their immunomodulatory and engraftmentpromoting properties, mesenchymal stromal cells (MSCs) have been tested in the clinical setting both to facilitate haematopoietic recovery and to treat steroid-resistant acute GVHD. More recently, experimental findings and clinical trials have focused on the ability of MSCs to home to damaged tissue and to produce paracrine factors with antiinflammatory properties, resulting in functional recovery of the damaged tissue. The mechanisms through which MSCs exert their therapeutic potential rely on some key properties of the cells: the ability to secrete soluble factors capable of stimulating survival and recovery of injured cells; the capacity to home to sites of damage and the ability to blunt exaggerated immune responses. These fundamental properties are being tested within a novel therapeutic field defined as Regenerative Medicine. This review deals with recent research on the anti-inflammatory/reparative properties of MSCs and considers the possible mechanisms of function responsible for these effects. Moreover, current and potential clinical applications of MSC-based treatment strategies in the context of Regenerative Medicine are being discussed. Key issues such as optimal timing of MSC administration, cell dose and schedule of administration, advantages and disadvantages of using autologous or allogeneic cells are still open. Nonetheless, MSCs promise to represent a revolution for many severe or presently untreatable disorders.

show abstract

Section: Neurodegenerative Disordersmentioning

confidence: 99%

Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine?

Bernardo

Pagliara

Locatelli

2011

Bone Marrow Transplant

137

109

View full text Add to dashboard Cite

show abstract

“…Similarly, somatosensory evoked potentials (SSEPs), motor evoked potentials (MEPs) and nerve conduction velocity (NCV) measurements revealed no significant changes. Despite this negative electrophysiological finding, patients did indeed report significant recovery: initially in bladder sensation, followed by bladder regulation and bowel function, then improvement in the sensory tract, and finally in motor function 20 . In a study by Ra et al, 8 male patients who had suffered from spinal cord injury for more than 12 months agreed to be submitted to an autologous transplantation of MSCs derived from adipose tissue (via the cephalic vein).…”

Section: Mesenchymal Stem Cells / Bone Marrow Stem Cellsmentioning

confidence: 99%

Current perspectives in stem cell therapy for spinal cord repair in humans: a review of work from the past 10 years

Mariano

Batista

Barbosa

et al. 2014

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Spinal cord injury (SCI) and amyotrophic laterals sclerosis (ALS) are devastating neurological conditions that affect individuals worldwide, significantly reducing quality of life, both for patients and their relatives. Objective: The present review aims to summarize the multiple restorative approaches being developed for spinal cord repair, the use of different stem cell types and the current knowledge regarding stem cell therapy. Method: Review of the literature from the past 10 years of human studies using stem cell transplantation as the main therapy, with or without adjuvant therapies. Conclusion: The current review offers an overview of the state of the art regarding spinal cord restoration, and serves as a starting point for future studies.Keywords: spinal cord injury, amyotrophic lateral sclerosis, stem cells, stem cell therapy. RESUMOLesão medular (LM) e esclerose lateral amiotrófica (ELA) são condições devastadoras que acometem pessoas em todo o mundo, reduzindo a qualidade de vida tanto de pacientes como de entes queridos. Objetivo: A atual revisão tem como alvo as múltiplas abordagens restauradoras para a regeneração medular, o uso de diferentes tipos celulares e o atual conhecimento a cerca da terapia com células tronco. Método: Revisão de literatura dos últimos 10 anos usando transplantes de células tronco como estratégia principal, com ou sem terapia adjuvante, em humanos. Conclusão: A presente revisão oferece uma visão geral acerca da restauração medular e serve de ponto de partida para estudos futuros.Palavras-chave: lesão medular, esclerose lateral amiotrófica, células tronco, terapia com células tronco.

show abstract

“…Another approach is to target the auto- Safety has been assessed by a few studies with a small number of patients using bone marrow derived cells, and reporting no serious adverse effects [54,55]. The main concerns though are possible tumor formation and increased chance of allodynic pain after transplantation, explained by aberrant axonal regeneration [56,57].…”

Section: Amyotrophic Lateral Sclerosismentioning

confidence: 99%

Stem cell therapy for neurological disorders

Baronica¹,

Friedrich²

2011

Translational Neuroscience

View full text Add to dashboard Cite

Stem cells have long been in focus as potential therapy or even cure for a whole myriad of diseases. Many neurodegenerative disorders, both acute and chronic, are characterized by irreversible neuronal damage and loss, and only a few efficient treatment options exist. In contrast to many other tissues, the potential of selfregeneration of the central nervous system is highly limited. There is hope that stem cells could replace the damaged neuronal and glial cells, and provide biological and functional restoration based on their properties of self renewal and the ability to give rise to different cells. In recent years, the promising results of research on animal models has led to the establishment of the first clinical trials; although no clear evidence of therapeutic benefit for any of the conditions have been ascertained. Here we give a review of the current strategies of stemcell based therapy for some of the more common neurological disorders, discussing the progress and current challenges, and giving an overview of future perspectives. introductionThere are two basic types of stem cells: 1. Another way to achieve cell replacement is to induce the activity of endogenous neural stem cells located in the central nervous system. These are found in the subventricular zone of the lateral ventricles [8,9] Huntington's disease discussion and conclusionsAs certain neurological diseases currently , 2006, 13, 379-388 [31] Bachoud-Lévi A. C., Gaura V., Brugières P., Lefaucheur J. P., Boissé M.

show abstract

Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study

Cited by 58 publications

References 0 publications

Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine?

Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine?

Current perspectives in stem cell therapy for spinal cord repair in humans: a review of work from the past 10 years

Stem cell therapy for neurological disorders

Contact Info

Product

Resources

About