Ex VivoExperiment on Radiofrequency Liver Ablation with Saline Infusion through a Screw-Tip Cannulated Electrode

Miao, Yi; Ni, Yicheng; Mulier, Stefaan; Wang, Kai; Hoey, Michael F.; Mulier, Peter; Penninckx, Freddy; Yu, Jing; Scheerder, Ivan De; Baert, A L; Marchal, Guy

doi:10.1006/jsre.1997.5133

Cited by 100 publications

(44 citation statements)

References 24 publications

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“…Moreover, in 2 cases, clots were found in the hepatic veins. For this reason, we considered pulmonary embolism as a possible explanation for their deaths; however, in clinical series, such complications have never been reported, to our knowledge in the literature [11]; however, the shape of the lesions were irregular as previously observed [12,13].…”

Section: Discussionmentioning

confidence: 63%

Radio-frequency tissue ablation of the liver: in vivo and ex vivo experiments with four different systems

et al. 2003

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The aim of this study was to test the efficacy of four different radio-frequency ablation (RFA) systems in normal hepatic parenchyma in large animals. The RFA was applied to pig livers in vivo and to calf livers ex vivo using the Radionics cluster needle, RITA starburst XL needle, Radiotherapeutics Le Veen 4.0 needle, and the Berchtold 14-G saline-perfused 15-mm active-tip needle based on constructor specifications. The volume of tissue coagulation from RF was calculated from measurements of the vertical diameter (Dv) and transverse diameter (Dt). Lesion shape was characterized using the ratio between Dt/Dv. Radiotherapeutics and RITA produced in vivo lesion volume of 42±10, 39±4 cm 3 with a reproducible spherical shape (Dt/Dv of 1.01±0.16 and 0.97±0.1, respectively). Radionics produced in vivo RF lesions volume of 29±11 cm 3 with an ovoid shape (Dt/Dv 0.88±0.09). The RF lesions with the Berchtold device could not be assessed in vivo as 5 of 8 animals died during treatment. Ex vivo RF lesions had similar volumes with each system; however, the Radiotherapeutics device produced more reproducible shaped lesions than the other systems. In our experimental study, we found no difference between expandable needle systems in vivo. Cooled needles produced slightly smaller and ovoid shape in vivo lesions.

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Section: Discussionmentioning

confidence: 63%

Radio-frequency tissue ablation of the liver: in vivo and ex vivo experiments with four different systems

et al. 2003

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“…Future numerical studies will investigate different electrode designs for hepatic ablation. Some of the new probe designs that have recently been proposed are bipolar electrodes (current flowing between the electrodes), instead of monopolar (current flowing from the conducting electrodes to the dispersive electrode on the patient's body), or the cooled tip electrodes [18]. …”

Section: )mentioning

confidence: 99%

Three-dimensional finite-element analyses for radio-frequency hepatic tumor ablation

Tungjitkusolmun

Staelin

Haemmerich

et al. 2002

IEEE Trans. Biomed. Eng.

297

184

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Abstract-Radio-frequency (RF) hepatic ablation, offers an alternative method for the treatment of hepatic malignancies. We employed finite-element method (FEM) analysis to determine tissue temperature distribution during RF hepatic ablation. We constructed three-dimensional (3-D) thermal-electrical FEM models consisting of a four-tine RF probe, hepatic tissue, and a large blood vessel (10-mm diameter) located at different locations. We simulated our FEM analyses under temperature-controlled (90 C) 8-min ablation. We also present a preliminary result from a simplified two-dimensional (2-D) FEM model that includes a bifurcated blood vessel. Lesion shapes created by the four-tine RF probe were mushroom-like, and were limited by the blood vessel. When the distance of the blood vessel was 5 mm from the nearest distal electrode 1) in the 3-D model, the maximum tissue temperature (hot spot) appeared next to electrods A. The location of the hot spot was adjacent to another electrode 2) on the opposite side when the blood vessel was 1 mm from electrode A. The temperature distribution in the 2-D model was highly nonuniform due to the presence of the bifurcated blood vessel. Underdosed areas might be present next to the blood vessel from which the tumor can regenerate.

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“…Furthermore, cells may be forced into the track by sudden intratumoral hyperpressure that is frequently encountered during RFA, audible as a popping sound. Finally, when using a wet electrode, cells may leak out the track together with the saline injected into the tumor [109,110,111]. …”

Section: Oncological Arguments With Direct Evidence Pro and Contra Rfmentioning

confidence: 99%

Radiofrequency Ablation versus Resection for Resectable Colorectal Liver Metastases: Time for a Randomized Trial?

et al. 2008

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Background: A recent proposal of a randomized trial comparing resection and radiofrequency ablation (RFA) in a selected subgroup of patients with small resectable colorectal liver metastases (CRLM) has initiated a debate on this issue. Meanwhile, new data have been published. The aim of the study was to update and critically review the oncological evidence in favor of and against the use of RFA for resectable CRLM in general and in favor of and against conducting a randomized trial in a selected subgroup of patients. Methods: An exhaustive review was carried out of papers and abstracts on RFA of colorectal metastases published before July 15, 2008. Results: Local recurrence rate after resection of CRLM is 1.2–10.4%. Local recurrence rate after RFA of CRLM is between 1.7 and 66.7%. For tumors <3 cm, local control after open RFA is equivalent to resection. Local recurrence rates, however, are higher for larger tumors and for the percutaneous and laparoscopic route. Accumulating evidence suggests that RFA and resection induce profoundly different biological effects, which may influence survival. Conclusions: Local recurrence rate after open RFA for CRLM <3 cm seems to be equivalent to resection. A randomized trial under strict conditions would be justified in this subgroup of patients. A randomized trial is currently not justified for larger tumors or for percutaneous or laparoscopic RFA, since local recurrence rates in these groups are too high to be acceptable for resectable tumors.

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Ex VivoExperiment on Radiofrequency Liver Ablation with Saline Infusion through a Screw-Tip Cannulated Electrode

Cited by 100 publications

References 24 publications

Radio-frequency tissue ablation of the liver: in vivo and ex vivo experiments with four different systems

Radio-frequency tissue ablation of the liver: in vivo and ex vivo experiments with four different systems

Three-dimensional finite-element analyses for radio-frequency hepatic tumor ablation

Radiofrequency Ablation versus Resection for Resectable Colorectal Liver Metastases: Time for a Randomized Trial?

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