Exacerbation d´un syndrome douloureux chronique diffus par l´introduction d´un inhibiteur de l´aromatase

Nemitz, N.; Kurmann, P. T.; Linthoudt, D. Van

doi:10.1024/1661-8157.97.3.137

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…Anastrozole is administered in a 1 mg dose per day, being capable of reducing body aromatization in 97%. Letrozole reduces the biosynthesis of estrogens in 99% with a 25 mg daily dose, and exemestane reduces it in 98% with a 25 mg daily dose 9 . The three drugs are related with a range of side effects that affect the quality of life of patients, often leading to therapy discontinuation.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the presence of estrogen receptors in areas of the central nervous system related to cognition, such as hippocampus, prefrontal cortex, amygdala and basal ganglia, the signs of difficulties in concentration and poor verbal memory can be explained by the reduced estrogen activity in these receptors. Estrogens also work in the promotion of neuroplasticity and regulation of learning and memory pathways, especially by the decreased synthesis of the n-methyl-d-aspartate receptor protein, involved in the glutamatergic activation of the hippocampus 3,9,21 .…”

Section: Other Side Effectsmentioning

confidence: 99%

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Most prevalent side effects of aromatase inhibitors in the treatment of hormone-positive breast cancer: a scoping review

Zuffo,

Ricardo,

Comnisky

et al. 2023

Mastology

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Hormone-positive breast cancer is the most commonly diagnosed breast neoplasm among postmenopausal women and is strongly associated with the effects of estrogens on hormone receptors of breast cells. Aromatase inhibitors are especially prescribed for treatment, and are effective to reduce mortality rates and the development of a new contralateral breast tumor. However, even with the proven efficacy and safety in use of these medications, approximately 50% of the patients abandon treatment before the prescribed period due to their side effects. The study was carried out with the objective of mapping what national and international literature declare about the most prevalent side effects caused by aromatase inhibitors in the treatment of women with hormonepositive breast cancer. We used the guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Review to elaborate this review. The methodology of choice was a scoping review aiming at synthetizing relevant information in an objective and clear manner about this drug class that is so common in breast cancer therapy, mainly benefitting women who are users of such drugs. According to the literature, reduced bone mineral density, arthralgia, hot flushes and dryness of the vaginal mucosa are the most reported symptoms, directly related with the absence of estrogen action on the body. These effects have a direct repercussion on the quality of life and on the discontinuation of treatment, leading to reduced functionality and high mortality rates.

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Section: Discussionmentioning

confidence: 99%

Section: Other Side Effectsmentioning

confidence: 99%

Most prevalent side effects of aromatase inhibitors in the treatment of hormone-positive breast cancer: a scoping review

Zuffo,

Ricardo,

Comnisky

et al. 2023

Mastology

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Musculoskeletal manifestations in patients with malignant disease

et al. 2009

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To detect and describe the incidence of musculoskeletal manifestations in different malignant diseases as well as their relation to the treatment received whether by chemotherapy or radiation therapy. Sixty patients with different malignant diseases were included in this study, 45 with solid tumors and 15 patients with hematological malignancy. The mean age was 46.55 +/- 11.04 years and the mean disease duration was 2 +/- 0.75 years. The patients were fully examined for any rheumatologic involvement, laboratory investigations were performed as well as dual energy X-ray absorptiometry study for bone densitometry. Treatment strategies were assessed including the chemotherapeutics, radiation therapy, and/or surgery. Myalgias and arthralgias were the most frequent followed by flexor tenosynovitis, frozen shoulder, and fibromyalgia syndrome. Hypertrophic osteoarthropathy was seen in five patients, cutaneous vasculitis in two patients as well as arthritis. Osteonecrosis was present in one of the lunate carpal bones of a patient with non-Hodgkin's lymphoma (1.67%) and receiving high dose steroids. Rheumatoid factor was positive in four patients, three of which had hepatitis C virus positivity and cryoglobulins. Anti-neutrophil cytoplasmic antibody was negative in all the studied patients. The bone mineral density was significantly reduced in the patients with malignancy compared to the control. Mild to moderate osteoporosis was present, being more evident in the spine and forearm. The bone loss was higher in those with solid tumors and even more obvious in those receiving aromatase inhibitors. Musculoskeletal manifestations occurring during malignancies and following the treatment represent a significant percentage of symptoms and signs which may raise a clue to differential diagnosis.

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Estrogenic influences in pain processing

Amandusson

Blomqvist

2013

Frontiers in Neuroendocrinology

111

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Gonadal hormones not only play a pivotal role in reproductive behavior and sexual differentiation, they also contribute to thermoregulation, feeding, memory, neuronal survival, and the perception of somatosensory stimuli. Numerous studies on both animals and human subjects have also demonstrated the potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and they therefore need to be evaluated specifically to determine the localization and intrinsic characteristics of the neurons engaged. The aim of this review is to summarize the morphological as well as biochemical evidence in support for gonadal hormone modulation of nociceptive processing, with particular focus on estrogens and spinal cord mechanisms.

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Exacerbation d´un syndrome douloureux chronique diffus par l´introduction d´un inhibiteur de l´aromatase

Cited by 5 publications

References 34 publications

Most prevalent side effects of aromatase inhibitors in the treatment of hormone-positive breast cancer: a scoping review

Most prevalent side effects of aromatase inhibitors in the treatment of hormone-positive breast cancer: a scoping review

Musculoskeletal manifestations in patients with malignant disease

Estrogenic influences in pain processing

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