Exacerbation of asthma and neutrophil-dominated airway inflammation in patients with cold-induced airway hyperresponsiveness

Introduction. The role of neutrophil inflammation of the bronchi in patients with asthma in the development and manifestation of cold airway hyperresponsiveness (CAHR) has not been sufficiently studied.Aim. To assess the level of neutrophils and the activity of myeloperoxidase (MPO) in the bronchi of asthma patients with cold-induced bronchospasm.Materials and methods. In 138 patients with mild-to-moderate asthma with CAHR, the level of asthma control (ACT), lung function (FEV1), cellular composition of sputum was examined before and after the bronchoprovocation test by isocapnic hyperventilation with cold air (IHCA). In sputum samples, the percentage of neutrophils, eosinophils, and bronchial epithelial cells (structurally intact cylindrical ciliated and goblet cells) was assessed; the concentration and activity of MPO in neutrophils were studied by the cytochemical method.Results. The patients were divided into three groups: group 1 (n=94) - patients with mild cold-induced bronchospasm, group 2 (n=28) - with moderate bronchospasm, group 3 (n=16) - with severe bronchospasm (AFEV1=- 13.5±0.3, -24.6±0.5, -36.9±1.5%, respectively). Patients did not differ in the level of asthma control (16 [12; 21]; 16 [13; 20] and 16 [12; 21] ACT points, respectively). Patients of the third group had lower values of bronchial patency in comparison with the first and second groups: FEV1 79.4±3.2; 92.4±1.7 (p<0.01); 92.1±2.9% and FEF25-75 46.4±4.3; 66.1±2.5 (p<0.001); 63.2±4.0% (p<0.01). In sputum after the IHCA test in groups 2 and 3, an increase in the number of neutrophils was recorded from 35.5±3.9 to 46.0±3.8% (p<0.05) and from 39.0±3.8 to 52, 4±4.4% (p<0.05), respectively, while the number of neutrophils in group 1 did not change (43.2±2.4 and 44.3±2.1%). The concentration of MPO in response to the IHCA test in all groups significantly increased by more than 30% (p<0.05).Conclusion. The mobilization of neutrophils in a mixed pattern of airway inflammation in asthma patients is associated with worsening of cold-induced bronchospasm. An increase in the content of MPO in neutrophil granules in response to the action of cold air is aimed at enhancing the secretion of the enzyme in the interstitium, activating its oxidative activity in the respiratory tract, and escalating the oxidative/halogenating stress that accompanies bronchospasm.

show abstract

Airway neutrophils and myeloperoxidase in asthma patients with cold-induced bronchoconstriction

Пирогов

Prikhodko

Perelman

2022

Bûlletenʹ fiziologii i patologii dyhaniâ

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Exacerbation of asthma and neutrophil-dominated airway inflammation in patients with cold-induced airway hyperresponsiveness

Cited by 1 publication

References 15 publications

Airway neutrophils and myeloperoxidase in asthma patients with cold-induced bronchoconstriction

Airway neutrophils and myeloperoxidase in asthma patients with cold-induced bronchoconstriction

Contact Info

Product

Resources

About