Exacerbation of diabetic renal failure following intravenous pyelography

Harkonen, Scott; Kjellstrand, Carl M.

doi:10.1016/0002-9343(77)90549-6

Cited by 144 publications

(49 citation statements)

References 24 publications

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“…The incidence of CN was 12.5 percent among our patients with diabetes mellitus and renal insufficiency, much lower than previously reported. [33] The late adverse reaction after dimeric CM administration may be explained on the basis of the presented cytokine dynamic. [22] In our study, two patients with CN had only IL-6 cytokine liberation.…”

Section: Discussionmentioning

confidence: 99%

“…There are limited clinical data in the nephrotoxicity of iodixanol in renal impairment. However, previous reports [32,33] with regard to CN after IVP in high-risk patients are primarily from western countries, and very few are from Taiwan. We designed a prospective, controlled study to compare the incidence of contrast nephrotoxicity between the iodixanol and iohexol contrast agent, especially in elderly or high-risk patients undergoing IVP.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Iodixanol and Iohexol in Patients Undergoing Intravenous Pyelography: A Prospective Controlled Study

et al. 2009

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182F.-R. Chuang et al.Background. Nephropathy associated with contrast medium exposure is a well-known complication of IVP. However, it is uncertain whether iso-osmolar non-iodinated contrast medium (iodixanol) is less nephrotoxic than low-osmolar contrast medium (iohexol). Materials and Methods. In this singlecenter, double-blind, prospective study, 50 patients undergoing IVP were randomized into two groups receiving different contrast medium: iodixanol and iohexol. Patients in high risk for contrast nephropathy were included, 28 with renal insufficiency and 19 with diabetes mellitus. We compared the nephrotoxic effect (contrast nephropathy), complement and cytokines profile between the iodixanol and iohexol groups. The mean volume of contrast medium in each IVP procedure was 0.8 mL/kg. Results. The incidence of contrast nephropathy was 4 percent among all patients (one iodixanol and one iohexol). We found no significant differences in contrast nephropathy and allergic reactions between the two groups. There was no significant difference in cytokine profiles in both groups (p > 0.05).The incidence of allergic reaction was 16 percent among all patients. Twelve percent (3/25) had late reaction after iohexol exposure compared to four percent (2/25) with iodixanol (p = 1.0). One patient had severe skin rash due to late adverse reaction after iodixanol. No mortality was found. Conclusions. New iodixanol and iohexol contrast medium for routine IVP examination are safe and have low nephrotoxicity profile, especially in elderly or high-risk patients. Iodixanol contrast medium has an increased risk to induce severe late adverse reaction compared to iohexol. Allergic reaction may be the main adverse effect after contrast medium infusion.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Iodixanol and Iohexol in Patients Undergoing Intravenous Pyelography: A Prospective Controlled Study

et al. 2009

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“…In diabetics with normal renal functions CIN was reported between 9-40% while with pre-existing renal disease there is a higher incidence of 50-90% are reported. [33][34][35][36] However Parfrey et al documented comparable incidences of CIN to healthy population in diabetics with preserved renal function. 37 In our study the reported frequency of CIN among diabetics was 3.57%.…”

Section: Discussionmentioning

confidence: 98%

CONTRAST-INDUCED NEPHROPATHY; INCIDENCES & RISK FACTORS AFTER CORONARY ANGIOGRAM

Asghar

Anees

2017

TPMJ

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ABSTRACT… Introduction: Contrast induced nephropathy (CIN) is a disorder characterized by the onset of acute renal failure within 24 to 72 hours after the administration of iodinated contrast medium after coronary angiography. CIN is associated with prolonged hospitalization and adverse clinical outcomes. The objective of this study is to determine the frequency of contrast induced nephropathy in patients of coronary artery disease undergoing coronary angiography in local population. Setting: Department of Cardiology, Faisalabad Institute of Cardiology. Period: 16-04-2016 to 15-10-2016. Subjects and Methods: 200 patients of coronary artery disease booked for coronary angiogram. Study design was Cross-sectional. Baseline characteristic and history of risk factors of coronary artery disease were noted. Serum creatinine level was recorded at baseline and after 48 hours of angiography by sending blood sample to the hospital pathology department and were noted. Contrast induced nephropathy was assessed. Results: Mean age of the patients was 53.61±12.48 year. Patients with age between 30-50 years were 76(38%) and patients with age 51-70 years were 124 (62%). Out of 200 patients, 130 (65%) were males while remaining 70 (35%) were females. In the study population 14 (7%) developed contrast induced nephropathy (CIN). Mostly patients of 51-70 years of age group developed CIN. CIN was reported in 9(6.92%) male patients and 5(7.1%) female patients. Among diabetic 4 (3.57%) patient developed CIN. Among hypertensive patients 2 (2.77%) patient developed CIN. Similarly in patients presented with acute coronary syndrome 8 (7.61%) patient developed CIN. Conclusion: In conclusion, contrast induced nephropathy in patients with coronary artery disease undergoing coronary angiogram was found in 7%. CIN is a relative common finding following coronary angiography in patients especially in elderly and male patients. More incidences of CIN were noted in patients presented with acute coronary syndrome and in diabetic patients. key words:Contrast induced nephropathy, Coronary angiography.

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“…However there is a higher occurrence rate of 50 -90%, in diabetic patients having pre-existing renal disease. 14,15 In comparison the frequency in the general population (diabetics and non-diabetics) is quite low ,falling in a range of less than 2%. 16 Diabetes is thought to be an independent risk factor for the occurrence of CIN.…”

Section: 64% N=7 Male Femalementioning

confidence: 92%

Frequency of Contrast Induced Nephropathy (CIN) Following Exposure to Contrast in Coronary Angiography, in Diabetics with Previously Normal Renal Function

Sajjad¹,

Ali²,

Akram³

2016

Annals KEMU

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Introduction: Contrast -induced nephropathy (CIN), is an acute kidney injury state, which has managed to catch the attention of cardiologists, as a result of increasing cardiac invasive interventions. Lately there has been a lot of research to get insight in the etiology, pathogenesis, recognition, diagnosis and prevention of CIN, so that the long term adverse effects can be avoided. Much of the research has been in the form of retrospective or observational studies on groups of patients undergoing angiographic contrast exposure. Objective: The objective of the study was to: Determine the frequency of CIN in diabetics undergoing coronary angiography. Study Design: Case series. Settings:

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Exacerbation of diabetic renal failure following intravenous pyelography

Cited by 144 publications

References 24 publications

Comparison of Iodixanol and Iohexol in Patients Undergoing Intravenous Pyelography: A Prospective Controlled Study

Comparison of Iodixanol and Iohexol in Patients Undergoing Intravenous Pyelography: A Prospective Controlled Study

CONTRAST-INDUCED NEPHROPATHY; INCIDENCES & RISK FACTORS AFTER CORONARY ANGIOGRAM

Frequency of Contrast Induced Nephropathy (CIN) Following Exposure to Contrast in Coronary Angiography, in Diabetics with Previously Normal Renal Function

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