The exact solutions of the Schrodinger equations (SE) in the D-dimensional coordinate system have attracted the attention of many theoretical researchers in branches of quantum physics and quantum chemistry. The energy eigenvalues and the wave function are the solutions of the Schrodinger equation that implicitly represents the behavior of a quantum mechanical system. This study aimed to obtain the eigenvalues, wave functions, and thermodynamic properties of the 6-Dimensional Schrodinger equation under Double Ring-Shaped Oscillator (DRSO) and Manning-Rosen potential. The variable separation method was applied to reduce the one 6-Dimensional Schrodinger equation depending on radial and angular non-central potential into five onedimensional Schrodinger equations: one radial and five angular Schrodinger equations. Each of these onedimensional Schrodinger equations was solved using the SUSY QM method to obtain one eigenvalue and one wave function of the radial part, five eigenvalues, and five angular wave functions angular part. Some thermodynamic properties such, the vibrational mean energy 𝑈, vibrational specific heat 𝐶, vibrational free energy 𝐹, and vibrational entropy 𝑆, were obtained using the radial energy equations. The results showed that except the 𝑛𝑙1, all increment of angular quantum number decreases the energy values. Increments of all potential parameter increase the energy values. Increment of angular quantum number and potentials parameter increases the amplitude and shifts the wave functions to the left. However, the increment of 𝑛𝑙1, 𝛼, 𝜎, and 𝜌 decrease the amplitude and shift wavefunctions to the right. Moreover, the vibrational mean energy 𝑈 and free energy 𝐹 increased as the increasing value of potentials parameters, where the ω parameter has the dominant effect than the other parameters. The vibrational specific heat 𝐶 and entropy 𝑆 affected only by the 𝜔 parameter, where 𝐶 and 𝑆 decreased as the increase of 𝜔.