2021
DOI: 10.1016/j.autneu.2021.102784
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Exaggerated sympathetic and cardiovascular responses to dynamic mechanoreflex activation in rats with heart failure: Role of endoperoxide 4 and thromboxane A2 receptors

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Cited by 7 publications
(13 citation statements)
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“…Thus, we believe the dynamic hindlimb muscle contraction maneuver is an excellent experimental model that can be used to study the EPR with substantial contribution from the mechanoreflex. In this regard, our present findings that the sympathetic and cardiovascular responses to dynamic muscle contraction were exaggerated in HF-rEF rats compared to SHAM rats builds upon our previous findings which showed that the sympathetic and cardiovascular responses to 1 Hz dynamic skeletal muscle stretch were exaggerated in HF-rEF rats compared to SHAM rats (Butenas, Rollins, et al, 2021). Our findings are also consistent with reports of greater sympathetic responses to single, 1 s hindlimb muscle contractions in HF-rEF rats compared to sham rats (Koba et al, 2008).…”
Section: Discussionsupporting
confidence: 88%
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“…Thus, we believe the dynamic hindlimb muscle contraction maneuver is an excellent experimental model that can be used to study the EPR with substantial contribution from the mechanoreflex. In this regard, our present findings that the sympathetic and cardiovascular responses to dynamic muscle contraction were exaggerated in HF-rEF rats compared to SHAM rats builds upon our previous findings which showed that the sympathetic and cardiovascular responses to 1 Hz dynamic skeletal muscle stretch were exaggerated in HF-rEF rats compared to SHAM rats (Butenas, Rollins, et al, 2021). Our findings are also consistent with reports of greater sympathetic responses to single, 1 s hindlimb muscle contractions in HF-rEF rats compared to sham rats (Koba et al, 2008).…”
Section: Discussionsupporting
confidence: 88%
“…Given we found no difference in TxA 2 -R expression within lumbar DRG or basal COX metabolites within the skeletal muscle interstitial space between SHAM and HF-rEF rats, how may we explain the effect of TxA 2 -R blockade on the sympathetic and cardiovascular responses to hindlimb muscle contraction (present study) and hindlimb muscle stretch (Butenas, Rollins, et al, 2021)? It is possible that the site of amplification of the TxA 2 -R signaling in HF-rEF resides within the intracellular pathways within the sensory neuron endings.…”
Section: Discussionmentioning
confidence: 78%
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