Examination, diagnosis and classification for Japanese allergic rhinitis: Japanese guideline

Fujieda, Shigeharu; Kurono, Yuichi; Okubo, Kimihiro; Ichimura, Keiichi; Enomoto, Tadao; Kawauchi, Hideyuki; Masuyama, Keisuke; Goto, Miho; Suzaki, Harumi; Okamoto, Yoshitaka; Takenaka, Hiroshi

doi:10.1016/j.anl.2011.12.006

Cited by 49 publications

(40 citation statements)

References 11 publications

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“…Scores were obtained for nasal symptoms, sneeze, rhinorrhoea and nasal congestion with the use of a 5-point scale (0 = none, 1 = mild, 2 = moderate, 3 = severe and 4 = very severe) based on the Japanese guidelines for allergic rhinitis [6]. Ocular symptoms (eye itchiness and watery eyes) were scored using a 4-point scale (0 = none, 1 = mild, 2 = moderate and 3 = severe).…”

Section: Methodsmentioning

confidence: 99%

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Efficacy and Safety of Sublingual Immunotherapy for Two Seasons in Patients with Japanese Cedar Pollinosis

Okamoto

Okubo

Yonekura

et al. 2015

Int Arch Allergy Immunol

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109

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Background: Japanese cedar (JC) pollinosis is the most common seasonal allergic rhinitis in Japan. Standardized JC pollen extract is available for subcutaneous immunotherapy, but this treatment is limited by potentially serious side effects. The aim of this double-blind, randomized comparative study was to evaluate the efficacy and safety of standardized JC pollen extract in a new oral formulation (CEDARTOLEN®, Torii Pharmaceutical Co., Ltd., Tokyo, Japan) for sublingual immunotherapy (SLIT) for JC pollinosis. Methods: A total of 531 subjects with JC pollinosis were randomized into 2 groups at a ratio of 1:1 to receive daily sublingual administration of standardized JC pollen extract with a maintenance dose of 2,000 Japanese allergy units (JAU) or placebo for 2 consecutive pollen seasons. The efficacy was evaluated using the total nasal symptom and medication score (TNSMS) as the primary end point. Secondary end points included the total ocular symptom and medication score (TOSMS) and scores for individual symptoms and medication. Results: The TNSMS was significantly lower (p < 0.0001) in the SLIT group than in the placebo group in the peak symptom period by 18 and 30% in the first and second seasons, respectively. All secondary end points were also significantly lower in the SLIT group in both seasons. No systemic anaphylaxis occurred. Conclusions: SLIT with daily administration of standardized JC pollen extract was effective for improving nasal and ocular symptoms of JC pollinosis and reducing the use of relief medication. The JC pollen extract was well tolerated with only local adverse events.

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Section: Methodsmentioning

confidence: 99%

“…This is followed by Japanese cypress pollen dispersal, which reaches a peak in early April. JC pollinosis is estimated to affect more than a quarter of the total Japanese population [6]. …”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Sublingual Immunotherapy for Two Seasons in Patients with Japanese Cedar Pollinosis

Okamoto

Okubo

Yonekura

et al. 2015

Int Arch Allergy Immunol

Self Cite

109

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“…A 5-point scale (0 = none, 1 = mild, 2 = moderate, 3 = severe, and 4 = very severe) for each symptom was used according to the Japanese guidelines for allergic rhinitis [1,3]. The total nasal symptom score (TNSS) was obtained by summing the scores for those three symptoms.…”

Section: Evaluation Of Symptomsmentioning

confidence: 99%

“…The severity of symptoms of pollen-induced allergic rhinitis is affected by the quantity of scattered pollen, and pollen avoidance using protective face masks and ventilation systems with appropriate filters are important methods of symptom control [1][2][3]. However, even when patients are exposed to the same amount of pollen, symptom severity varies greatly.…”

Section: Introductionmentioning

confidence: 99%

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The Relationship of Pollen Dispersal with Allergy Symptoms and Immunotherapy: Allergen Immunotherapy Improves Symptoms in the Late Period of Japanese Cedar Pollen Dispersal

Sakurai

Yonekura

Iinuma

et al. 2018

Int Arch Allergy Immunol

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Background: The severity of symptoms of pollen-induced allergic rhinitis is affected by the amount of scattered pollen. However, the relationships between the pollen dispersal pattern, symptom severity, and treatment efficacy are not clear. Methods: Between 2007 and 2012, we performed 4 randomized, placebo-controlled studies of sublingual immunotherapy (SLIT) on patients with Japanese cedar-induced allergic rhinitis who lived in or around Chiba, Japan. The participants were asked to avoid using rescue medicines during the cedar pollen season as much as possible and to record their nasal symptoms in allergy diaries. The amount of pollen dispersed daily was quantified using the Durham method, and the season was divided into early and late periods based on the pollen count. Results: A total of 721 patients were enrolled in the 4 studies during the 6-year study period. In the placebo group (n = 349), a correlation was observed between the amount of pollen dispersed and the severity of symptoms in the early but not late period of pollen dispersal. Treatment with SLIT (n = 372) significantly improved symptom severity in the late but not early period. Conclusion: For patients with Japanese cedar pollen-induced allergic rhinitis, the fluctuation of daily pollen dispersal had a minimal effect on the severity of symptoms during the late period. SLIT was remarkably effective in alleviating symptoms during this period but not in the early period.

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Peripheral basophil reactivity, CD203c expression by Cryj1 stimulation, is useful for diagnosing seasonal allergic rhinitis by Japanese cedar pollen

Imoto

Takabayashi

Sakashita

et al. 2015

Immunity Inflam & Disease

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Measuring specific IgE can yield direct, accurate, and objective data. Nevertheless, clinical symptoms of allergy are often inconsistent with these data. Recently, the expression of CD203c, a surface marker of basophils, has been reported as capable of distinguishing allergic patients. This study compared specific IgE in serum and skin tests against antigen to assess CD203c as a biomarker correlated with allergic rhinitis (AR). We asked 3,453 subjects whether they experienced any AR related symptom. All subjects were assessed for six specific IgEs for common aeroallergens. Skin tests were also conducted for six aeroallergens. We observed the reactivity of peripheral basophil by measuring the levels of CD203c by Cryj1 stimulation using flow cytometry. Of the 3,453 participants, 1,987 (57.5%) possessed Japanese cedar pollen (JCP) specific IgE in their serum. Among those 1,987 JCP specific IgE positive participants, 552 (27.8%) had not experienced any allergic symptom during the JCP season. The levels of CD203c in the peripheral basophil by Cryj1 stimulation were significantly higher in SAR-JCP subjects than in non-SAR-JCP subjects (Cryj1 0.5 ng/ml: 2.25 ± 0.90% vs. 60.2 ± 27.4%, p < 0.01, Cryj1 50 ng/ml: 1.89 ± 0.90% vs. 68.0 ± 21.2%, p < 0.01). Our results indicate that the levels of CD203c in peripheral basophils by Cryj1 stimulation is a more objective and reliable marker that better reflects the allergic reaction by SAR-JCP in vivo than measuring specific IgE in serum or skin tests.

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Examination, diagnosis and classification for Japanese allergic rhinitis: Japanese guideline

Cited by 49 publications

References 11 publications

Efficacy and Safety of Sublingual Immunotherapy for Two Seasons in Patients with Japanese Cedar Pollinosis

Efficacy and Safety of Sublingual Immunotherapy for Two Seasons in Patients with Japanese Cedar Pollinosis

The Relationship of Pollen Dispersal with Allergy Symptoms and Immunotherapy: Allergen Immunotherapy Improves Symptoms in the Late Period of Japanese Cedar Pollen Dispersal

Peripheral basophil reactivity, CD203c expression by Cryj1 stimulation, is useful for diagnosing seasonal allergic rhinitis by Japanese cedar pollen

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