2007
DOI: 10.1016/j.placenta.2007.05.001
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Examination of Glucocorticoid Receptor α-Mediated Transcriptional Regulation of P-glycoprotein, CYP3A4, and CYP2C9 Genes in Placental Trophoblast Cell Lines

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Cited by 73 publications
(40 citation statements)
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“…Previous studies have shown that high-affinity binding of GR to the phosphoenolpyruvate carboxykinase gene promoter is strictly dependent on associated accessory factor elements, including HNF4 (Stafford et al, 2001). Moreover, we have recently shown that CYP3A4 and CYP2C9 promoters are activated by GR in placental cells only after cotransfection with HNF4␣ (Pavek et al, 2007). However, the novelty of the findings of the current study is that the mechanism by which GR and HNF4␣ cooperatively transactivate CYP2A6 is independent of a GRE.…”
Section: Hnf4␣ and Induction Of Cyp2a6 By Dexamethasone 457mentioning
confidence: 54%
“…Previous studies have shown that high-affinity binding of GR to the phosphoenolpyruvate carboxykinase gene promoter is strictly dependent on associated accessory factor elements, including HNF4 (Stafford et al, 2001). Moreover, we have recently shown that CYP3A4 and CYP2C9 promoters are activated by GR in placental cells only after cotransfection with HNF4␣ (Pavek et al, 2007). However, the novelty of the findings of the current study is that the mechanism by which GR and HNF4␣ cooperatively transactivate CYP2A6 is independent of a GRE.…”
Section: Hnf4␣ and Induction Of Cyp2a6 By Dexamethasone 457mentioning
confidence: 54%
“…40) GR and VDR, but not PXR, are expressed in both placental syncytiotrophoblast and cytotrophoblast. 41,42) Pavek et al reported that expression of CYP3A4 mRNA in placenta trophoblast cell line JEG3 cells was not changed significantly after treatment with dexamethasone. 42) They also indicated that non-responsiveness of CYP3A4 promoter to glucocorticoids is responsible for low expression of HNF4a because CYP3A4 promoter was activated in placenta cells only after co-transfection with HNF4a.…”
Section: Discussionmentioning
confidence: 99%
“…We also suggest there is a significant correlation between P-gp function in T lymphocytes and prednisolone dose for treatment in this study. Although the direct effect of GC receptors on the transcriptional regulation of P-gp in T lymphocytes is not clear, it has been suggested that GC receptor alpha is involved in the increased P-gp expression and/or function in the placental trophoblasts [29]. Thus, long-term and/or high dose administration of prednisolone may increase functional P-gp copies on T cells, which may result in resistance to GC therapy.…”
Section: Discussionmentioning
confidence: 99%