Examination of lung toxicity, oxidant/antioxidant status and effect of erdosteine in rats kept in coal mine ambience

Armutçu, Ferah; Gün, Banu Doğan; Altın, Remzi; Gürel, Ahmet

doi:10.1016/j.etap.2007.03.002

Cited by 27 publications

(20 citation statements)

References 43 publications

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“…All the exposed subjects showed enhanced plasma TBARS levels, an OS marker of lipid oxidation. Similar results were also found in coal mining workers at early stages of pneumoconiosis [10], and also in rats exposed to coal mine ambience [22]. Interestingly, in the late study, after treatment with the antioxidant erdosteine, levels of lipoperoxidation were similar to those of controls.…”

Section: Before the Antioxidant Interventionsupporting

confidence: 73%

“…On the other hand, rats exposed sub-chronically to a mine ambience showed SOD and GPx induction at the first week followed by SOD inhibition at the fourth week of exposure [22]. Accordingly, coal miners showed a progressive loss of an adequate antioxidant compensation regarding SOD and GPx activities in plasma, which were parallel to the tissue damage [10].…”

Section: Before the Antioxidant Interventionmentioning

confidence: 89%

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Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Possamai¹,

Avila²,

Filho³

2015

eee

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Emissions of different types of airborne particulate matter (PM) is associated either with occupational contamination that affect both, workers directly exposed to the distinct PM sources such as incineration of solid residues of health services, coal mining and also coal burning derived from an electric-power plant, as well as the population living in the vicinity of such emissions. Such contamination leads to endogenous overgeneration of reactive oxygen species (ROS) in different cells and tissues and therefore to a systemic oxidative stress (OS). Enzymatic and non-enzymatic OS biomarkers were measured in the blood of workers directly and indirectly (near the emissions) exposed and also in subjects indirectly exposed living in the vicinities of these PM emissions, before and after a six months antioxidant intervention of a daily oral supplementation of vitamins C (500 mg) and E (400 mg). Compared to baseline values, the antioxidant intervention after 6 months was able to confer a consistent and protective effect against the systemic OS irrespective of the PM source of the airborne contaminants. The results clearly indicate that supplementation with antioxidant vitamins could be recommended in order to attenuate the deleterious consequences of a systemic OS associated with such PM emissions.

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Section: Before the Antioxidant Interventionsupporting

confidence: 73%

Section: Before the Antioxidant Interventionmentioning

confidence: 89%

Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Possamai¹,

Avila²,

Filho³

2015

eee

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“…Hasil penelitian ini berbeda dengan penelitian Armutcu dkk. 7 yang mendapatkan peningkatan kadar MDA plasma pada paparan tambang bawah. Perbedaan ini diduga disebabkan oleh lama waktu paparan setiap hari, untuk penelitian ini 1 jam per hari sedangkan Armutcu dkk.…”

unclassified

“…Perbedaan ini diduga disebabkan oleh lama waktu paparan setiap hari, untuk penelitian ini 1 jam per hari sedangkan Armutcu dkk. 7 selama 24 jam per hari. Selanjutnya, peroksidasi lipid akibat paparan debu batubara tidak berkorelasi dengan kadar gula darah.…”

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Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes Melitus

Yuwono¹,

Setiawan²,

Kania³

et al. 2011

mkb

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AbstrakDi Kalimantan Selatan, prevalensi penderita diabetes melitus sebesar 11,1%. Kalimantan Selatan merupakan provinsi dengan tambang batubara tersebar di seluruh wilayah. Hal ini menjadikan penderita diabetes melitus terpapar debu batubara. Penelitian ini bertujuan untuk mengukur peroksidasi lipid akibat paparan debu batubara subkronik dan pengaruhnya pada kadar gula darah tikus diabetes melitus. Kelompok penelitian meliputi tikus Wistar diabetes melitus (P1), kelompok diabetes melitus + paparan debu batubara dosis 12,5 mg/m 3 1 jam/hari selama 28 hari (P2), dan kelompok diabetes melitus + paparan debu batubara dosis 25 mg/m 3 1 jam/hari selama 28 hari (P3), masing-masing 6 ekor. Penelitian dilakukan mulai Agustus-Oktober 2010. Uji analysis of variance (ANOVA) terhadap kadar malondialdehid (MDA) plasma tidak didapatkan peningkatan secara bermakna antara kelompok perlakuan (p>0,05). Penurunan kadar gula untuk P1, P2, dan P3 berturut-turut sebesar 23,6%, 16,9%, dan 9,3%. Analisis uji t tidak berpasangan terhadap kadar gula darah tidak didapatkan perbedaan bermakna sebelum dan setelah perlakuan pada semua kelompok (p>0,05). Tidak terdapat korelasi antara kadar MDA plasma dan kadar gula darah setelah perlakuan pada berbagai kelompok (p>0,05). Disimpulkan bahwa paparan debu batubara subkronik tidak meningkatkan peroksidasi lipid yang mempengaruhi kadar gula darah pada tikus diabetes melitus dan tidak ada korelasi antara kadar MDA dan glukosa darah. [MKB. 2011;43(4):189-92].Kata kunci: Debu batubara, diabetes melitus, hiperglikemia, peroksidasi lipid Subchronic Coal Dust Exposure on Lipid Peroxidation and Blood Glucose Level in Diabetes Mellitus Rat AbstractIn South Kalimantan, prevalence of diabetes mellitus was 11.1%. South Kalimantan is a province with coal mine spread in all districts. This condition induce coal dust exposure on diabetes mellitus patients. Aim of this study was to measure lipid peroxidation by subchronic coal dust exposure and its effect on glucose level in Wistar rats model of diabetes mellitus. Group included diabetes mellitus Wistar rats (P1), diabetes mellitus + coal dust exposure at dose 12.5 mg/m 3 1 hour/day for 28 days (P2) and diabetes mellitus + coal dust exposure at dose 25 mg/m 3 1 hour/day for 28 days (P3) on 6 rats, respectively. This research was done from August-October 2010. Analysis of variance (ANOVA) test concluded no significant differently on increased plasma malondialdehyde (MDA) level between all groups (p>0.05). Percentage of blood glucose level decreased 23.6%, 16.9% and 9.3% for P1, P2, P3 group, respectively. Unpaired t test concluded that blood glucose level were not significant differently between pre and post treatment in all groups (p>0.05). There was no correlation between plasma MDA level and blood glucose level in all groups of exposure (p>0.05). In conclusions, that subchronic coal dust exposure doesn't increase lipid peroxidation and no effect on blood glucose level in diabetes mellitus rats and no correlation between MDA dan blood glucose level. [MKB. 2011;...

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“…Endothelial cell damage due to dyslipidemia plays a critical role in the development and progression of atherosclerosis [10,11]. Several studies showed that coal dust produces proinflammatory cytokines and free radicals in vitro [12,13] in rats [1,14] and humans [15,16] but for dyslipidemia and endothelial damage is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol Lowering Effect of Subchronic Inhalation Particulate Matter 10 Coal Dust on Rats

Setiawan¹,

Darsuni²,

Muttaqien³

et al. 2013

Med-Science

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Examination of lung toxicity, oxidant/antioxidant status and effect of erdosteine in rats kept in coal mine ambience

Cited by 27 publications

References 43 publications

Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Systemic Oxidative Stress Promoted by Emissions of Particulate Matter is Attenuated by Antioxidant Supplementation

Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes Melitus

Cholesterol Lowering Effect of Subchronic Inhalation Particulate Matter 10 Coal Dust on Rats

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