Examination of the behavior and liver and thyroid histology of juvenile rainbow trout (Oncorhynchus mykiss) exposed to high dietary concentrations of C10-, C11-, C12- and C14-polychlorinated n-alkanes

Cooley, Helen M; Fisk, Aaron T.; Wiens, Susanna C.; Tomy, Gregg T.; Evans, R. E.; Muir, Derek C.G.

doi:10.1016/s0166-445x(00)00172-7

Cited by 87 publications

(57 citation statements)

References 21 publications

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“…To further analyse thyroid status after T3 treatment, thyroid follicle number (Fig.·9A) and thyrocyte cell height [index of thyroid activity (Cooley et al, 2001;Kalisnik et al, 1977); Fig.·9B], was assessed during normal sea bream ontogeny and during treatment with T3 (Fig.·9). In control larvae, follicle number was constant throughout the course of the experiment (HSD, P>0.05; Fig.·9B).…”

Section: T3 Treatment -Sea Bream Tnt Expressionmentioning

confidence: 99%

Regulation of troponin T expression during muscle development in sea breamSparus auratusLinnaeus: the potential role of thyroid hormones

Campinho

Sweeney

Power

2006

Journal of Experimental Biology

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SUMMARY In the sea bream Sparus auratus three stage-specific fast troponin T (fTnT) isoforms have been cloned and correspond to embryonic-, larval- and adult-specific isoforms. Characterisation, using database searches, of the putative genomic organisation of Fugu rubripes and Tetraodon nigroviridis fTnT indicates that alternative exon splicing in the 5 region of the gene generates the different isoforms. Moreover, comparison of teleost fTnTs suggests that alternative splicing of fTnT appears to be common in teleosts. A different temporal expression pattern for each fTnT splice varotnt is found during sea bream development and probably relates to differing functional demands, as a highly acidic embryonic form (pI 5.16) is substituted by a basic larval form (pI 9.57). Thyroid hormones (THs), which play an important regulatory role in muscle development in flatfish and tetrapods,appear also to influence TnT gene expression in the sea bream. However, THs have a divergent action on different sea bream TnT genes and although the slow isoform (sTnT1) is TH-responsive, fTnT, sTnT2 and the itronless isoform (iTnT) are unaffected. The present results taken together with those published for flatfish seem to suggest differences may exist in the regulation of larval muscle development in teleosts.

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Section: T3 Treatment -Sea Bream Tnt Expressionmentioning

confidence: 99%

Regulation of troponin T expression during muscle development in sea breamSparus auratusLinnaeus: the potential role of thyroid hormones

Campinho

Sweeney

Power

2006

Journal of Experimental Biology

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“…4−9 Compared to other two groups of CP mixtures, SCCPs have received growing global attention in recent years for their long-range transport, 10,11 persistence in the environment, 12 bioaccumulation in food webs, 13 and potential toxicity to aquatic organisms. 14,15 Currently, SCCPs are being reviewed by Stockholm Convention's POP Review Committee (POPRC) to evaluate whether this substance meet the criteria on persistent organic pollutants (POPs). 16 However, to date, very limited data for environmental fate and toxicology of SCCPs are available as a result of the complexity of their compositions and the challenge for quantifying these compounds.…”

Section: ■ Introductionmentioning

confidence: 99%

Behavior, Fate, and Mass Loading of Short Chain Chlorinated Paraffins in an Advanced Municipal Sewage Treatment Plant

Zeng

Wang

et al. 2013

Environ. Sci. Technol.

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Sewage treatment plants (STP) are an important source of short chain chlorinated paraffins (SCCPs) to the ambient environment through discharge of effluent and application of sludge. In this work, a field study was conducted to determine the behavior and possible removal of SCCPs during the sewage treatment process in an advanced municipal STP in Beijing, China. SCCPs were detected in all sewage water and sludge samples, and 97% of the initial mass loading in raw sewage was found to be associated with suspended matter. The total concentrations in raw influent, tertiary effluent, and dewatered sludge were 184 ± 19 ng/L, 27 ± 6 ng/L, and 15.6 ± 1.4 μg/g dry weight (d.w.), respectively. The dissolved concentrations of total SCCPs (∑SCCPs) significantly decreased during mechanical, biological, and chemical treatments. SCCP homologue profiles in aqueous phase were distinctly different from those in solid phase. Along the treatment process, the relative abundance of shorter chain and lower chlorinated congeners gradually increased in sewage water, but no obvious variations of homologue profiles were found in sludge. Mass flow analysis indicated, the removal efficiency in aqueous phase for ∑SCCPs was 82.2%, and the congener-specific removal efficiencies were positively related to their solid−water partition coefficients (K d ). Mass balance results indicated that 0.8% and 72.6% of the initial SCCP mass loading were ultimately found in the effluents and dewatered sludge, respectively, while the remaining 26.6% was lost mainly due to biodegradation/ biotransformation. It was suggested that the activated sludge system including basic anaerobic−anoxic−aerobic processes played an effective role in removing SCCPs from the wastewater, while the sorption to sludge by hydrophobic interactions was an important fate of SCCPs during the sewage treatment.

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“…Of all the CP mixtures, SCCPs tend to behave in a similar way to persistent organic pollutants (POPs), leading to some countries and organizations to impose regulation on the production and use of these compounds (Pellizzato et al, 2009). Because of their persistence (Iozza et al, 2008), toxicity (Cooley et al, 2001;Warnasuriya et al, 2010), bioaccumulation (Fisk et al, 1996;Houde et al, 2008;Zeng et al, 2011b) and potential for long-range transport abilities (Tomy et al, 1999), SCCPs have been listed as POP candidate by the Stockholm Convention. However, data on the distributions, environmental fate and toxicity of SCCPs are still scarce compared to other POPs, mainly due to the complexity of analytical methodologies (Eljarrat and Barcelo, 2006;Santos et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Levels and distribution patterns of short chain chlorinated paraffins in sewage sludge of wastewater treatment plants in China

Zeng

Wang

Ruan

et al. 2012

Environmental Pollution

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a b s t r a c tShort chain chlorinated paraffins (SCCPs) are listed as persistent organic pollutant candidates in the Stockholm Convention and are receiving more and more attentions worldwide. In general, concentrations of contaminants in sewage sludge can give an important indication on their pollution levels at a local/regional basis. In this study, SCCPs were investigated in sewage sludge samples collected from 52 wastewater treatment plants in China. Concentrations of total SCCPs (SSCCPs) in sludge were in the range of 0.80e52.7 mg/g dry weight (dw), with a mean value of 10.7 mg/g dw. Most of SCCPs in the sludge samples showed a similar congener distribution patterns, and C 11 and Cl 7,8 were identified as the dominant carbon and chlorine congener groups. Significant linear relationships were found among different SCCP congener groups (r 2 ! 0.9). High concentrations of SCCPs in sewage sludge imply thatSCCPs are widely present in China.

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Examination of the behavior and liver and thyroid histology of juvenile rainbow trout (Oncorhynchus mykiss) exposed to high dietary concentrations of C10-, C11-, C12- and C14-polychlorinated n-alkanes

Cited by 87 publications

References 21 publications

Regulation of troponin T expression during muscle development in sea breamSparus auratusLinnaeus: the potential role of thyroid hormones

Regulation of troponin T expression during muscle development in sea breamSparus auratusLinnaeus: the potential role of thyroid hormones

Behavior, Fate, and Mass Loading of Short Chain Chlorinated Paraffins in an Advanced Municipal Sewage Treatment Plant

Levels and distribution patterns of short chain chlorinated paraffins in sewage sludge of wastewater treatment plants in China

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