“…However, for depressive symptoms, multivariate analyses indicated the absence of an association with opioid use (2 analyses showing a positive association [ 86 , 101 ] and 4 no association [ 62 , 86 , 101 , 121 ]—33%). Moreover, no evidence was found for a relationship between depressive symptoms and prescription pain medication use (univariate: 2 analyses showing a positive association [ 48 , 76 ] and 16 no association [ 48 , 49 ]—11%), OTC pain medication use (univariate: 1 analyses showing a positive association [ 48 ] and 4 no association [ 48 , 49 ]—20%), having primary care consultation (univariate: 2 analyses showing a positive association [ 112 ] and 5 no association [ 48 , 104 ]—29%), undergoing invasive procedures (univariate: 1 analysis showing a positive association [ 48 ] and 4 no association [ 48 , 131 ]—20%) and using CAM services (univariate: 6 analyses showing a positive association [ 48 , 73 , 115 ] and 23 no association [ 48 , 73 , 77 , 112 ]—21%; multivariate: 5 analyses showing no association [ 73 , 115 ]—0%) in people with pain.…”