Interest of registries in neuropathic pain research

Moisset, Xavier; Pagé, M. Gabrielle

doi:10.1016/j.neurol.2021.07.011

Cited by 7 publications

(5 citation statements)

References 26 publications

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“… 20 Unlike many registries, the QPR provides rich information regarding clinical/medical data and outcome measures, including specific standardized diagnostic codes assigned by treating physician and treatment and medical history collected through a telephone interview with a nurse. 20 , 21 …”

Section: Methodsmentioning

confidence: 99%

Characteristics of Persons Seeking Care for Moderate to Severe Pain Due to Chronic Low Back Pain and Osteoarthritis: A Cross-Sectional Study

Pagé¹,

Tousignant-Laflamme²,

Dorais³

et al. 2022

JPR

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Purpose To assess the associations between pain severity or physical (pQoL) and mental (mQoL) health-related quality of life and disability status or health-care utilization among persons living with moderate/severe pain due to chronic low back pain (CLBP) or osteoarthritis (OA), who received treatments in Quebec’s tertiary care pain centers. Materials and Methods This retrospective study was carried out using the Quebec Pain Registry (Canada) from 2008 to 2014 and contains data on persons referred to tertiary pain management clinics. Participants were selected if they were diagnosed with CLBP (N = 2663) or OA (N = 139) of more than 3 months duration and of pain intensity ≥5 on the Numeric Rating Scale (0–10) and completed baseline questionnaires. Results Less than 5% of persons were hospitalized in the 6 months before their first visit at the pain clinic, and 11.9% and 18.9% of persons with OA and CLBP, respectively, had a pain-related emergency room (ER) visit. Less than 1/5 and more than 1/4 of persons with OA and CLBP were receiving disability benefits, respectively. Persons with CLBP who had visited the ER, those on disability and those receiving disability benefits, reported higher levels of pain severity, interference, and lower levels of mQoL (and pQoL for those on disability or receiving benefits) compared to those who did not consult the ER, those not on disability or not receiving disability benefits, respectively (all p < 0.05). For OA, disability status was the only variable associated with pain interference and QoL (all p < 0.05). Conclusion Pain severity, pain interference and mQoL were associated with health-care utilization and disability status in persons with CLBP. These results were globally not found among persons with OA, which might be due to smaller sample size or unique characteristics of this population.

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Section: Methodsmentioning

confidence: 99%

Characteristics of Persons Seeking Care for Moderate to Severe Pain Due to Chronic Low Back Pain and Osteoarthritis: A Cross-Sectional Study

Pagé¹,

Tousignant-Laflamme²,

Dorais³

et al. 2022

JPR

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“…Interest in registries specific to pain is growing. The International Association for the Study of Pain (IASP) has convened a special interest group for pain registries; the National Institutes of Health in the United States is now running a national pain registry; and more specialized registries are being set up by organizations and societies [ 50 - 53 ]. Among these registries are the Swedish Quality Registry for Pain Rehabilitation, the Quebec Pain Registry, the international registry entitled PAIN-OUT, the Oslo University Hospital Pain Registry, and e-DOL, which started in 2019 in France and is supported by mobile devices [ 53 ].…”

Section: Reviewmentioning

confidence: 99%

What’s New in Neuropathy?

Varrassi,

Tamburin,

Zis

et al. 2023

Cureus

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Neuropathic pain presents diagnostic and treatment challenges. Despite recent advances in our understanding of the diagnosis and treatment of neuropathy, much remains to be elucidated. Familiar with neuropathy is the paradox that aberrant nerve signaling causes both sensory loss and pain. Voltage-gated sodium channels play an important role in neuronal electrogenesis and communication among neurons, and their dysregulation leads to hyperexcitability and pain. While numerous validated diagnostic assessment tools are available for neuropathy, patients often experience a diagnostic delay about the cause of their neuropathy. New research is defining more specific types of neuropathy beyond peripheral and central forms. The prevalence of pain varies by type of neuropathy, with chronic idiopathic axonal polyneuropathy associated with the highest proportion of patients experiencing pain. In the majority of types, it exceeds 50%. Gluten neuropathy, a form of peripheral neuropathy, is a new diagnostic consideration. It may require electrochemical conductance testing of hands and feet to test for sudomotor dysfunction. Among those with serologically confirmed gluten sensitivity or celiac disease, gluten neuropathy is a common neurological manifestation and may be addressed at least partially by a gluten-free diet. In Greece, a new neuropathic pain registry was created in 2014 in order to help gather data from real-world neuropathic pain patients. While still in its earliest phase, this registry has already produced demographic and treatment data that suggest suboptimal prescribing and less than recommended use of interventional procedures. Awareness campaigns are underway to encourage more Greek pain clinics to participate in this important registry.

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“…Երևանի Մխիթար Հերացու անվան պետական բժշկական համալսարան, ֆարմակոլոգիայի ամբիոն 0025, Երևան, Կորյունի փ․, 2 Բանալի բառեր․ պիրոգլուտամիլԳԱԿԹ, պրեգաբալին, նեյրոպաթիկ ցավ, hot plate թեստ, հականոցիցեպտիվ ակտիվություն Աշխարհի բնակչության մոտ 7-10%-ը տառապում է տարբեր ծագման նեյրոպաթիկ ցավերից (ՆՑ), [9,12]: Սոմատոսենսոր համակարգի դիսֆունկցիայի արդյունքում զարգացող զգայական խանգա-րումների՝ հիպերալգեզիայի, ալլոդինիայի և քրոնիկ ցավերի տևական ընթացքը [7,19] և բուժման նկատմամբ տոլերանտությունը վատթարացնում են միլիոնավոր մարդկանց կյանքի որակը [15]: Ուստի միանգամայն հիմնավորված է, որ նեյրոպաթիկ ցավի կառավարման նպատակով նոր դեղերի փնտրտուքը շարունակում է մնալ արդի բժշկագիտության կարևորագույն խնդիրներից մեկըֈ Եվ չնայած այս նպատակով մշակված դեղերի լայն տեսականուն՝ կիրառվող հայտնի ցավազրկողները չեն ապահովում բավարար արդյունավետություն, իսկ կողմնակի ազդեցությունները շատ հաճախ սահմանափակում են այդ դեղերի կիրառությունը [6,14]:…”

Section: նհ․ ադամյանunclassified

Նեյրոպաթիկ Ցավի Կանխումը ՊիրոգլուտամիլԳԱԿԹ Դիպեպտիդով

Ադամյան¹

2022

Medical Science of Armenia

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The analgesic activity of pyroglutamylGABA in combination with pregabalin was studied in neuropathic pain model of sciatic nerve chronic constriction injury. Rat’s pain behavior was studied using hot plate test. The investigated agents were administered intraperitoneally, at a dose of 20 mg / kg each, twice a day. Conducted experiments revealed the synergistic effect in analgesic activity of pyroglutamylGABA and pregabalin, which was confirmed by analysis of changes in frequency and latency of licking, jumping and locomotor activity of rats, caused by neuropathic pain. It is noteworthy that obtained analgesic action of investigated combination appears without sedation characteristic for pregabalin. Thus, the obtained data of synergism in analgesic action of pyroglutamylGABA and pregabalin combination could serve as a basis for preclinical trials for development of new agent for neuropathic pain management without side effects like sedation.

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Interest of registries in neuropathic pain research

Cited by 7 publications

References 26 publications

Characteristics of Persons Seeking Care for Moderate to Severe Pain Due to Chronic Low Back Pain and Osteoarthritis: A Cross-Sectional Study

Characteristics of Persons Seeking Care for Moderate to Severe Pain Due to Chronic Low Back Pain and Osteoarthritis: A Cross-Sectional Study

What’s New in Neuropathy?

Նեյրոպաթիկ Ցավի Կանխումը ՊիրոգլուտամիլԳԱԿԹ Դիպեպտիդով

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