Examination of the effects of microRNA-145-5p and phosphoserine aminotransferase 1 in colon cancer

Ding, Ruliang; Hong, Weiwen; Huang, Liang; Shao, Jinfan; Yu, Wenfeng; Xu, Xiping

doi:10.1080/21655979.2022.2071010

Cited by 9 publications

(7 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relevant studies showed that miRNA can target the expression of proto-oncogenes or tumor suppressor genes to regulate the biological behavior of tumors [ 21 ]. For example, in colon cancer cell lines, miRNA-145-5p can regulate the expression of phosphoserine aminotransferase 1 (PSAT1) and inhibit the proliferation of colon cancer cells [ 22 ]. In addition, miR-451 was found to inhibit the epithelial mesenchymal transition (EMT) of glioma cells, as well as its invasion and metastasis [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous Cell Carcinoma Progression through ERK Pathway

Hu,

He,

Han

et al. 2024

IJMS

View full text Add to dashboard Cite

Hypopharyngeal squamous cell carcinoma (HSCC) is a kind of malignant tumor with a poor prognosis and low quality of life in the otolaryngology department. It has been found that microRNA (miRNA) plays an important role in the occurrence and development of various tumors. This study found that the expression level of miRNA-107 (miR-107) in HSCC was significantly reduced. Subsequently, we screened out the downstream direct target gene Neuronal Vesicle Trafficking Associated 1 (NSG1) related to miR-107 through bioinformatics analysis and found that the expression of NSG1 was increased in HSCC tissues. Following the overexpression of miR-107 in HSCC cells, it was observed that miR-107 directly suppressed NSG1 expression, leading to increased apoptosis, decreased proliferation, and reduced invasion capabilities of HSCC cells. Subsequent experiments involving the overexpression and knockdown of NSG1 in HSCC cells demonstrated that elevated NSG1 levels enhanced cell proliferation, migration, and invasion, while the opposite effect was observed upon NSG1 knockdown. Further investigations revealed that changes in NSG1 levels in the HSCC cells were accompanied by alterations in ERK signaling pathway proteins, suggesting a potential regulatory role of NSG1 in HSCC cell proliferation, migration, and invasion through the ERK pathway. These findings highlight the significance of miR-107 and NSG1 in hypopharyngeal cancer metastasis, offering promising targets for therapeutic interventions and prognostic evaluations for HSCC.

show abstract

Section: Discussionmentioning

confidence: 99%

miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous Cell Carcinoma Progression through ERK Pathway

Hu,

He,

Han

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Gastrointestinal cancer is one of the most important cancers worldwide. The incidence of digestive tract cancer in China is rising rapidly, and its morbidity and mortality rates are closely behind those of lung cancer, which has the highest incidence in China (17,18). Early gastrointestinal cancers include rectal cancer, biliary tract cancer, gastric cancer, esophageal cancer, pancreatic cancer, colorectal cancer, and hepatocellular carcinoma (19).…”

Section: Discussionmentioning

confidence: 99%

Comparison of efficacy and safety between endoscopic mucosal dissection and resection in the treatment of early gastrointestinal cancer and precancerous lesions: a systematic review and meta-analysis

Liu¹,

Yue²,

Wang³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

Background: Endoscopic mucosal dissection (EMD) is a new treatment method. Whether its clinical efficacy and safety are superior to surgical resection is still controversial. The sample size of previous studies on EMD for the treatment of early cancer of digestive tract is small, and there is no reliable evidence at present. Therefore, it is necessary to evaluate the efficacy and safety of EMD based on the evidence of evidence-based medicine. Methods:The PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure, Wanfang, cqvip.com (VIP), websites and citation searching were searched to obtain relevant literature on EMD for early cancer and precancerous lesions of digestive tract. The retrieval time was from the establishment of the database to November 29th, 2022. Literature was screened according to inclusion and exclusion criteria and data and data were extracted. The final included literature was assessed by Cochrane risk of bias tool, and publication bias was assessed by Egger's test.Results: A total of 10 articles were included, with a total of 1,165 patients. Among these, 585 cases were treated with EMD and 580 cases were in the control group. The literature quality evaluation found that 5 articles had low risk of bias and 5 articles had unclear risk of bias. The results showed that the complete resection rate in the observation group was higher than that in the control group [risk ratio (RR) =1.25, 95% confidence interval (CI): 1.15-1.35, P<0.01]. Cumulative intraoperative blood loss (P<0.01), operation time (P<0.01), postoperative complications (P<0.01), hospital stay (P<0.01), and hospitalization expenses (P<0.01) in the observation group were lower than those in the control group.Conclusions: EMD for early gastrointestinal cancer and precancerous lesions can improve the complete resection rate of tumors; reduce intraoperative blood loss, complications, operation time, and hospitalization time and cost. However, due to the small number of literatures included in this paper, the quality of literatures is not high, and some results have heterogeneous interference, the conclusion needs to include more high-treatment studies for further study.

show abstract

“…Its expression is regulated by p53 and other transcriptional factors [ 56 ]. The tumor-suppressive role of miR-145 has been suggested in diverse types of cancers [ 57 , 58 , 59 ], such as breast cancer [ 60 ], gastric cancer [ 61 ], bladder cancer [ 62 ], colorectal cancer [ 63 , 64 ], and ovarian cancer [ 65 ]. It has been sponged by multiple circular RNAs and lncRNAs, leading to deregulation of downstream gene targets ( Figure 9 ).…”

Section: Discussionmentioning

confidence: 99%

A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence

Toraih

Fawzy

Niu

et al. 2022

Cancers

View full text Add to dashboard Cite

Papillary thyroid carcinomas (PTCs) account for most endocrine tumors; however, screening and diagnosing the recurrence of PTC remains a clinical challenge. Using microRNA sequencing (miR-seq) to explore miRNA expression profiles in PTC tissues and adjacent normal tissues, we aimed to determine which miRNAs may be associated with PTC recurrence and metastasis. Public databases such as TCGA and GEO were utilized for data sourcing and external validation, respectively, and miR-seq results were validated using quantitative real-time PCR (qRT-PCR). We found miR-145 to be significantly downregulated in tumor tissues and blood. Deregulation was significantly related to clinicopathological features of PTC patients including tumor size, lymph node metastasis, TNM stage, and recurrence. In silico data analysis showed that miR-145 can negatively regulate multiple genes in the TC signaling pathway and was associated with cell apoptosis, proliferation, stem cell differentiation, angiogenesis, and metastasis. Taken together, the current study suggests that miR-145 may be a biomarker for PTC recurrence. Further mechanistic studies are required to uncover its cellular roles in this regard.

show abstract

Examination of the effects of microRNA-145-5p and phosphoserine aminotransferase 1 in colon cancer

Cited by 9 publications

References 39 publications

miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous Cell Carcinoma Progression through ERK Pathway

miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous Cell Carcinoma Progression through ERK Pathway

Comparison of efficacy and safety between endoscopic mucosal dissection and resection in the treatment of early gastrointestinal cancer and precancerous lesions: a systematic review and meta-analysis

A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence

Contact Info

Product

Resources

About