Examination of the Nitric Oxide Production-Suppressing Component in Tinospora tuberculata.

Yokozawa, Takako; Tanaka, Takashi; Kimura, Takeatsu

doi:10.1248/bpb.24.1153

Cited by 16 publications

(11 citation statements)

References 17 publications

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“…Similarly, authentication of all the secondary metabolites should be performed carefully by advanced analytical techniques to approve the quality and conforming biological activity. Most of the mentioned pharmacological studies have provided some suggestive scientific evidence for its various traditional uses in fever, internal inflammation (Yokozawa et al, 2000 , 2001 ; Kamarazaman et al, 2012a ), pain (Almeida et al, 2001 ; Sulaiman et al, 2008 ), antibacterial (Zakaria et al, 2006 ; Chittur and Gunjan, 2012 ), malaria (Niljan et al, 2014 ), diabetes (Lokman et al, 2013 ; Ruan et al, 2013 ), and hypertension (Praman et al, 2011 , 2013 ) as in Asian countries, especially in Malaysia, Indonesia, Philippines, China, Cambodia, and Bangladesh.…”

Section: Discussionmentioning

confidence: 99%

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Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects

2016

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Tinospora crispa (L.) Hook. f. & Thomson (Menispermaceae), found in the rainforests or mixed deciduous forests in Asia and Africa, is used in traditional medicines to treat numerous health conditions. This review summarizes the up-to-date reports about the ethnobotany, phytochemistry, pharmacological activities, toxicology, and clinical trials of the plant. It also provides critical assessment about the present knowledge of the plant which could contribute toward improving its prospect as a source of lead molecules for drug discovery. The plant has been used traditionally in the treatment of jaundice, rheumatism, urinary disorders, fever, malaria, diabetes, internal inflammation, fracture, scabies, hypertension, reducing thirst, increasing appetite, cooling down the body temperature, and maintaining good health. Phytochemical analyses of T. crispa revealed the presence of alkaloids, flavonoids, and flavone glycosides, triterpenes, diterpenes and diterpene glycosides, cis clerodane-type furanoditerpenoids, lactones, sterols, lignans, and nucleosides. Studies showed that the crude extracts and isolated compounds of T. crispa possessed a broad range of pharmacological activities such as anti-inflammatory, antioxidant, immunomodulatory, cytotoxic, antimalarial, cardioprotective, and anti-diabetic activities. Most pharmacological studies were based on crude extracts of the plant and the bioactive compounds responsible for the bioactivities have not been well identified. Further investigations are required to transform the experience-based claims on the use of T. crispa in traditional medicine practices into evidence-based information. The plant extract used in pharmacological and biological studies should be qualitatively and quantitatively analyzed based on its biomarkers. There should be detail in vitro and in vivo studies on the mechanisms of action of the pure bioactive compounds and more elaborate toxicity study to ensure safety of the plant for human use. More clinical trials are encouraged to be carried out if there are sufficient preclinical and safety data.

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Section: Discussionmentioning

confidence: 99%

“…Bioassay-guided isolation of the aqueous extract showed that N-trans-feruloyltyramine was the active constituent responsible for the inhibition of NO and this inhibition was linked with reduced levels of inducible NO synthase (iNOS) expression. (Yokozawa et al, 2000 , 2001 ).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects

2016

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“…The ferulamide 7 is reportedly contained in a garden plant, petunia (Jassey et al, 1982), and the indolylferulamide 9 is present in safflower seeds (Sato et al, 1985), sweet corn kernels (Ehmann, 1974), and bark of a tropical tree (Vecchietti et al, 1979). p-Hydroxyphenethylferulamide 11 is contained in pepper root (Yoshihara et al, 1981) and beet (Kujala et al, 2002), and as an anti-inflammatory constituent in some herbs (Yokozawa et al, 2001). In addition, several ferulamides including 5 and 11 were shown to stimulate insulin secretion in cultured pancreatic cells (Nomura et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Induction of adiponectin by natural and synthetic phenolamides in mouse and human preadipocytes and its enhancement by docosahexaenoic acid

2008

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“…crispa acted in concert on the cardiovascular system of anesthetized rats [ 142 , 143 ]. Compounds 175 – 178 are homologous provided with identical basic skeleton [ 149 , 150 ].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Genus Tinospora: Ethnopharmacology, Phytochemistry, and Pharmacology

Chi

She

Han

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The genus Tinospora includes 34 species, in which several herbs were used as traditional medicines by indigenous groups throughout the tropical and subtropical parts of Asia, Africa, and Australia. The extensive literature survey revealed Tinospora species to be a group of important medicinal plants used for the ethnomedical treatment of colds, headaches, pharyngitis, fever, diarrhea, oral ulcer, diabetes, digestive disorder, and rheumatoid arthritis. Indian ethnopharmacological data points to the therapeutic potential of the T. cordifolia for the treatment of diabetic conditions. While Tinospora species are confusing in individual ingredients and their mechanisms of action, the ethnopharmacological history of those plants indicated that they exhibit antidiabetic, antioxidation, antitumor, anti-inflammation, antimicrobial, antiosteoporosis, and immunostimulation activities. While the clinical applications in modern medicine are lacking convincing evidence and support, this review is aimed at summarizing the current knowledge of the traditional uses, phytochemistry, biological activities, and toxicities of the genus Tinospora to reveal its therapeutic potentials and gaps, offering opportunities for future researches.

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Examination of the Nitric Oxide Production-Suppressing Component in Tinospora tuberculata.

Cited by 16 publications

References 17 publications

Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects

Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects

Induction of adiponectin by natural and synthetic phenolamides in mouse and human preadipocytes and its enhancement by docosahexaenoic acid

Genus Tinospora: Ethnopharmacology, Phytochemistry, and Pharmacology

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