Examination of the role of catecholamines in hepatic glutathione suppression by cole-restraint in mice

Simmons, Henry F.; James, Robert C.; Harbison, Raymond D.; Patel, D. G.; Roberts, Stephen M.

doi:10.1016/0300-483x(91)90161-s

Cited by 15 publications

(10 citation statements)

References 15 publications

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“…Immobilization and/or cold stress decreased significantly ANND activity, but did not influence the cytochrome P-450 content or activities of CCR and APND in mice non-infected with influenza virus. There is a discrepancy between our results and the previously published data, which indicates a significant increase of LPO products in the target organs of animals subjected to immobilization or cold stress (Simmons et al 1991;Das and Banerjee 1993;Kovacheva-Ivanova et al 1994;Oishi et al 1999). The discrepancies in the results cited above may be explained by the different experimental protocols.…”

Section: Discussioncontrasting

confidence: 97%

“…Immobilization and cold-restraint stress are widely used experimental models that are accompanied by considerable decrease of antioxidative capacity of the animal organism (Simmons et al 1991;Das and Banerjee 1993;Kovacheva-Ivanova et al 1994;Oishi et al 1999). Thus, these models may be used for indirect modulation of antioxidant deficiency in the liver.…”

Section: Introductionmentioning

confidence: 99%

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Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice

Mileva

Bakalova

Tancheva

et al. 2002

Archives of Toxicology

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To cite this version:M. Mileva, R. Bakalova, L. Tancheva, S. Galabov. Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice.. Archives of Toxicology, Springer Verlag, 2002, 76 (2) Abstract The present study provides a direct experimental evidence that the combination of influenza A/ Aichi/2/68 (H3N2) infection with different models of ''oxidative stress'', such as immobilization, cold and cold-restraint, is associated with graduated oxidative disturbances in the liver of mice, despite the absence of virus and inflammation in this tissue. It was found that experimental influenza virus infection is accompanied with a significant increase of lipid peroxidation products, a decrease of natural antioxidants (vitamin E, glutathione) and cytochrome P-450, an inhibition of cytochrome c reductase and liver monooxygenases (analgin-Ndemethylase and amidopyrine-N-demethylase). Immobilization and cold stress, applied separately or in combination (cold-restraint), did not influence significantly any of the analysed parameters compared to those of the control group of non-infected mice. Preliminary exposure of mice to immobilization or cold stress and subsequent inoculation of influenza virus resulted in a significant increase of lipid peroxidation products and a significant decrease of vitamin E and reduced glutathione, compared with levels in control (non-infected) animals. Compared to influenza virus-infected and nonstressed animals, the changes in all these parameters were negligible. Immobilization or cold stress, applied in combination with influenza virus infection, partially prevented the suppressive effect of influenza virus on cytochrome P-450 and liver monooxygenases. A tendency towards normalization of these parameters to the control levels was observed. However, after application of cold-restraint plus influenza virus infection, the level of cytochrome P-450 and activity of cytochrome c reductase stayed markedly lower than in infected and non-stressed animals. The activities of liver monooxygenases were slightly increased compared with those of infected and non-stressed animals, but stayed relatively low compared to control (non-infected) mice. Combination of coldrestraint and influenza virus infection resulted in a greater synergistic increase of lipid peroxidation products and a greater synergistic decrease of vitamin E and reduced glutathione compared to controls, as well as to influenza virus-infected and non-stressed animals.

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Section: Discussioncontrasting

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice

Mileva

Bakalova

Tancheva

et al. 2002

Archives of Toxicology

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“…42) It has been reported that extracellular dopamine levels in the cortex are higher in socially isolated mice compared to group-housed mice 43) and that monoamines and related metabolites are capable of scavenging free radicals, chelating metal ions and inhibiting lipid peroxidation. 44) Thus, it will be interesting to investigate further if catecholamine metabolism contributes to social isolation stress-induced oxidative damage in the brain, and whether majonoside-R2 exerts antioxidant activity via catecholamine pathway.…”

Section: Discussionmentioning

confidence: 99%

Social Isolation Stress-Induced Oxidative Damage in Mouse Brain and Its Modulation by Majonoside-R2, a Vietnamese Ginseng Saponin

Hương

Murakami

Tohda

et al. 2005

Biological & Pharmaceutical Bulletin

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Lipid peroxidation induced by oxidative stress is a consequence of the production of excess free radicals, such as reactive oxygen species, and provides marked damage to the structure and function of cell membranes in various tissues.1,2) Particularly, the brain is susceptible to free radical insults because it contains a high concentration of easily peroxidizable polyunsaturated fatty acids, and is not particularly enriched in protective antioxidant enzymes or other antioxidant compounds.

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“…[1][2][3] Thus plasma levels of NE, EPI, and DOPAC in response to the variable stressors R, RWI, and FS were measured by the decapitation method in mice. Plasma NE and EPI levels measured using the decapitation method were approximately 300-fold and 40-fold higher, respectively, than levels reported in plasma obtained from rats by the catheter method under basal conditions.…”

Section: Discussionmentioning

confidence: 99%

“…There are few reports of the measurement of catecholamines and their metabolites in mouse blood, [1][2][3] although catecholamines and their metabolites in plasma are good indicators of physical and mental states. [4][5][6][7][8][9][10][11][12][13] Thus we collected mouse blood using the decapitation method, which provides a rapid and convenient method for collecting sufficient blood for measurement.…”

mentioning

confidence: 99%

Increases in Plasma Dihydroxyphenylacetic Acid Levels in Decapitated Mice after Exposure to Various Stresses.

Harikai

Fujii

Onodera

et al. 2002

Biological & Pharmaceutical Bulletin

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This study investigated changes in plasma levels of the dopamine metabolite dihydroxyphenylacetic acid (DOPAC) in decapitated mice in response to the variable stresses of restraint, restraint and water immersion, and foot shock. DOPAC levels, but not norepinephrine (NE) and epinephrine (EPI) levels, increased upon exposure to these stresses. Plasma DOPAC levels measured using the decapitation method in rats were then compared with those measured using the catheter method. The NE and EPI levels in plasma measured using the decapitation method were much higher than those using the catheter method under basal conditions. In contrast, differences in the levels of DOPAC in plasma were smaller than those of NE and EPI under basal conditions using in both methods; furthermore parallel changes in plasma DOPAC levels occurred during restraint and water immersion stresses. These results indicate that the plasma DOPAC levels measured in mice using the decapitation method were clearly increased by the different stresses. Furthermore, in rats there were correlations between the decapitation and catheter methods for plasma levels of DOPAC. Thus the change in plasma DOPAC levels measured using the decapitation method is a good indicator of stress responses involving sympathoneural activity.

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Examination of the role of catecholamines in hepatic glutathione suppression by cole-restraint in mice

Cited by 15 publications

References 15 publications

Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice

Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice

Social Isolation Stress-Induced Oxidative Damage in Mouse Brain and Its Modulation by Majonoside-R2, a Vietnamese Ginseng Saponin

Increases in Plasma Dihydroxyphenylacetic Acid Levels in Decapitated Mice after Exposure to Various Stresses.

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