“…Early-onset alcohol abuse is predicted by undercontrolled behavior at age 3 years (Caspi et al, 1996), high novelty-seeking and low harm avoidance in childhood (Cloninger et al, 1988;Masse and Tremblay, 1997) and adolescence (Wills et al, 1994), and externalizing (conduct problems) symptoms in early adolescence (Chassin et al, 1999). Early-onset antisocial (type II/B) alcoholism has been associated with disinhibited personality traits such as impulsivity, boredom susceptibility, thrill-and adventure-seeking (Sullivan et al, 1990;von Knorring et al, 1985von Knorring et al, , 1987, novelty-seeking (Ball, 1996;Ball et al, 1998;Sullivan et al, 1990;Yoshino et al, 1994), and aggressiveness (Babor et al, 1992;von Knorring et al, 1987). Although observational studies of children clearly implicate low harm avoidance in the development of substance use (Cloninger et al, 1988;Masse and Tremblay, 1997), low harm avoidance is not consistently reported in questionnaire studies of antisocial EOA (Ball et al, 1998;Sullivan et al, 1990;Yoshino et al, 1994).…”