Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy

Jagodić, Jovana; Pavlović, Slađan; Borković-Mitić, Slavica; Perović, Milan; Miković, Željko; Đurđić, Slađana; Manojlović, Dragan; Stojsavljević, Aleksandar

doi:10.3390/ijms23158078

Cited by 13 publications

(2 citation statements)

References 55 publications

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“…Compared with other studies, the concentrations of Cd in maternal blood, placenta, and umbilical cord blood in Kunming, China were higher than those in Slovenia, 18 Germany (Saudi), 19 Sweden, 20 and Beijing and Zhejiang, China, 21,22 but the concentrations of Cd in maternal blood and umbilical cord blood in Kunming, China were lower than those in Catalonia, Spain 23 and Brazil (Rio de Janeiro). 24 Studies in other regions of the world have reported that the content of Cd in the placenta is higher than that in maternal blood and umbilical cord blood, [25][26][27] which is consistent with our results. As a temporary multifunctional organ connecting the mother and fetus, 28 the placenta plays an important role in filtering and blocking harmful substances.…”

Section: Comparison Of Mt and Cd-mt Expression Levelssupporting

confidence: 91%

Placental Barrier on Cadmium Transfer from Mother to Fetus in Related to Pregnancy Complications

Dong¹,

Ding²,

Hu³

et al. 2023

IJWH

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Purpose As two of the most severe and common medical disorders during pregnancy, gestational diabetes mellitus (GDM) and hypertensive disorder complicating pregnancy (HDCP) cause adverse effects on placental barrier function and thus may lead to a high risk of intrauterine exposure to toxic metals from mother to fetus. This study investigates the impact of the placental barrier on the transfer of cadmium (Cd) from mother to fetus and the relationship between pregnancy complications. Methods A total of 107 pairs of samples were collected in Kunming, China; 29 were from healthy pregnant women, and 78 were from patients with pregnancy complications. Cd was measured in each mother’s placenta and maternal and umbilical cord blood. The expressions of MT and Cd-MT complex in blood and placental tissue samples were determined by enzyme-linked immunosorbent assay (ELISA). Results The cesarean section rate in the whole pathological group (60.7%) was higher than that in the normal group (20.7%), and the ratio of the effective barrier (ratio of maternal blood to umbilical cord blood>1) in the pathological group (74%) was lower than that in the normal group (79%). In addition, the proportion of practical placental barriers in women aged 20–25 years was 83.3%, 76.3% in women aged 26–30 years, 74.3% in women aged 31–35 years, 70% in women aged 36–40 years, and 71% in women aged 40–45 years. The Cd content in the placenta of the three pathological groups was significantly higher than that in maternal and umbilical cord blood ( P <0.05), and the distribution of Cd was the same as that in the normal group. However, there was no significant difference between maternal and umbilical cord blood Cd concentrations in the pathological group. The Cd concentration in the normal group’s maternal blood was significantly higher than that in cord blood ( P <0.05). In addition, the expression levels of both metallothionein (MT) and Cd-MT complex in placenta is much higher than in maternal and umbilical blood, and which in normal group are significantly higher than those in pathological group. Conclusion Both mothers and fetuses are at increased health risk for pregnancy disorders when maternal age, BMI, or body weight increases. Increased maternal age increases the likelihood of Cd transfer from the mother to the fetus. Pregnancy complications may induce lower expression of MT, thus reducing the Cd-MT complex in the placenta, weakening the placental barrier, and increasing the risk of Cd transfer and exposure to the fetus.

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Section: Comparison Of Mt and Cd-mt Expression Levelssupporting

confidence: 91%

Placental Barrier on Cadmium Transfer from Mother to Fetus in Related to Pregnancy Complications

Dong¹,

Ding²,

Hu³

et al. 2023

IJWH

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“…Additionally, these mechanisms may differ considerably from other environmental exposures, given that in contrast to many other toxicants, relatively little cadmium crosses the placenta to directly impact the fetus in animals and human studies; instead, the placenta highly concentrates cadmium [ 13 , 14 , 15 , 16 ]. This results in cadmium levels in placental tissue being four times higher than cadmium levels in maternal serum and six times higher than cadmium level in umbilical cord serum [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy

Rivera‐Núñez

Hansel

Capurro

et al. 2023

Toxics

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Cadmium exposure has been associated with adverse perinatal outcomes. One possible mechanism is endocrine disruption. Studies of non-pregnant adults suggest that cadmium impacts androgen production; here, we examined these associations during pregnancy. Participants in the Understanding Pregnancy Signals and Infant Development (UPSIDE) cohort provided biospecimens and questionnaire data in each trimester (n = 272). We quantified urinary cadmium, serum total testosterone (TT), estrone, estradiol, and estriol and serum free testosterone (fT). In adjusted longitudinal models, we examined sex steroid concentrations across pregnancy in relation to specific gravity-adjusted, ln-transformed cadmium concentrations. Additionally, we examined trimester-specific associations and stratified models by fetal sex. Results are presented as percent change (%∆) in hormone concentrations. In longitudinal models, higher cadmium concentrations were associated with lower fT across pregnancy (%∆ = −5.19, 95%CI: −8.33, −1.93), with no differences in other hormones observed. In trimester-specific models, higher cadmium concentrations were associated with lower TT in trimester 2 (%∆ = −15.26, 95%CI: −25.15, −4.06) and lower fT in trimester 3 (%∆ = −14.35, 95%CI: −19.75, −8.59). Associations with TT were stronger in pregnancies carrying female fetuses. Maternal cadmium exposure may be associated with reduced testosterone in pregnancy. Additional work is necessary to understand how alterations in gestational testosterone activity may impact pregnancy and child health.

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Effect of environmental air pollutants on placental function and pregnancy outcomes: a molecular insight

Singh,

Goel,

Tripathi

et al. 2024

Environ Sci Pollut Res

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Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy

Cited by 13 publications

References 55 publications

Placental Barrier on Cadmium Transfer from Mother to Fetus in Related to Pregnancy Complications

Placental Barrier on Cadmium Transfer from Mother to Fetus in Related to Pregnancy Complications

Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy

Effect of environmental air pollutants on placental function and pregnancy outcomes: a molecular insight

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