Examining the Complicated Relationship Between Depressive Symptoms and Cognitive Impairment in Preclinical Alzheimer Disease

Javaherian, Kavon; Newman, Brianne M.; Weng, Hua; Hassenstab, Jason; Xiong, Chengjie; Coble, Dean W.; Benzinger, Tammie L.S.; Morris, John C.

doi:10.1097/wad.0000000000000284

Cited by 14 publications

(10 citation statements)

References 42 publications

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“…Our findings are in line with other studies (Garay, 2007;Plati et al , 2006). Recent studies have shown that over time depression predicts cognitive impairment (Chan et al, 2019;Dean, Oulhaj, Zamboni, Dejager, & Wilcock, 2014) and Alzheimer's disease (Javaherian et al, 2019;Ruthirakuhan et al, 2019).…”

Section: Discussionsupporting

confidence: 93%

The Relationship Between Depression and Cognitive Deterioration in Elderly Persons

Conde

Galán-López²

2021

Psic.: Teor. e Pesq.

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The objective of this research is to describe the relationship between depressive disorder and cognitive deterioration in residentialized elderly people. This is a descriptive and correlational study with 70 elderly. The variables have been assessed with a Psychosocial Variables Questionnaire, CAMCOG and GDS. Depression was significantly correlated with cognitive level in the non-assisted elderly sample (r=0.471, p=0.004). Participants’ age is negatively associated with the score obtained in the CAMCOG of non-assisted sample (r=-0.352, p=0.038). Depression is more frequent in institutions that care for older people when they are more dependent.

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Section: Discussionsupporting

confidence: 93%

The Relationship Between Depression and Cognitive Deterioration in Elderly Persons

Conde

Galán-López²

2021

Psic.: Teor. e Pesq.

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“…This view is also supported by a review by Mcintyre et al ( 58 ), that posits that a subgroup of individuals with MDD show progressive decline in memory. A study on late-life depression suggested that depressive symptoms were a prodrome for Alzheimer ( 59 ), that could suggest a dementia state effect on reduced memory in late life MDD (see Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Cognitive Impairment and Neurocognitive Profiles in Major Depression—A Clinical Perspective

2022

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Increasingly, studies have investigated cognitive functioning from the perspective of acute state- to remitted phases of Major Depressive Disorder (MDD). Some cognitive deficits observed in the symptomatic phase persist in remission as traits or scars. The etiological origin and clinical consequences of the neurocognitive profiles reported in the literature are still unclear and may vary across populations. Deficits are suspected to influence the association between MDD and neurodegenerative disorders and could thus be of particular clinical consequence. The aim of this review is to describe the clinical neuropsychological profile in MDD and how it is related to research during the past decade on cognitive deficits in MDD from a state, trait, and scar perspective. This review, with a clinical perspective, investigates research from the past decade regarding cognitive functioning in MDD in a long-term perspective. We focus on the clinical manifestation of deficits, and the potential neurodegenerative consequences of the neurocognitive profile in MDD. Searches in Medline, PsycINFO and Embase were conducted targeting articles published between 2010 and 2020. Examination of the evidence for long-lasting neurocognitive deficits in major depression within the cognitive domains of Memory, Executive Functions, Attention, and Processing Speed was conducted and was interpreted in the context of the State, Scar and Trait hypotheses. Defining the neurocognitive profiles in MDD will have consequences for personalized evaluation and treatment of residual cognitive symptoms, and etiological understanding of mood disorders, and treatments could potentially reduce or delay the development of neurodegenerative disorders.

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“…In addition, moderately significant cognitive impairments in executive functions and attention tasks, and minor nonsignificant impairments in memory, were found to persist in patients whose depressive symptoms had remitted, indicating that cognitive impairment occurs separately from episodic depression to major depressive disorder. Some recent studies showed that depression predicts conversion to cognitive impairment over time [117, 118] or the development of AD [119, 120].…”

Section: Discussionmentioning

confidence: 99%

Depression and Cognitive Impairment in Institutionalized Older Adults

Conde

Galán-López²

2020

Dement Geriatr Cogn Disord

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Background: In the last three decades, the relationship between depression and cognition in geriatric patients has been a popular topic among researchers and clinicians. Clinical and epidemiological research has focused on the identification of risk factors that could be modified in pre-dementia syndromes, at a preclinical and early clinical stage of dementia disorders, with specific attention to the role of depression. The objective of this work was to determine the relationship between depressive disorder and cognitive deterioration in institutionalized older adults. Methods: In this descriptive, correlational study, data were gathered from two nursing homes in the province of Jaen (Spain), from a random sample of 140 older adults (70 nondependent and 70 dependent). The variables were measured using comprehensive geriatric assessment, the Cambridge Cognitive Test (CAMCOG), and the Geriatric Depression Scale (GDS). Results: Depression was correlated with cognitive level in the nondependent older adult sample (r =-0.471, p = 0.004). Age was inversely associated with the score obtained in the CAMCOG of the nondependent older adult sample (r =-0.352, p = 0.038). The functional capacity in several activities of daily living was correlated with the score obtained in the CAMCOG in each of the two groups. Depression was more prevalent in the dependent than in the nondependent older adults (82.85 vs. 57.14%). No association was observed between institutionalization time and the score obtained on the cognitive and affective scales (GDS and CAMCOG) in both groups (GDS-nondependent, r =-0.209, p = 0.234; CAMCOG-nondependent, r = 0.007, p = 0.967; GDS-dependent, r = 0.251, p = 0.152; CAMCOG-dependent, r =-0.021, p = 0.907). Conclusion: Depressive symptomatology is associated with cognitive deterioration. Depression is prevalent in institutions that care for older, more dependent adults.

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Examining the Complicated Relationship Between Depressive Symptoms and Cognitive Impairment in Preclinical Alzheimer Disease

Cited by 14 publications

References 42 publications

The Relationship Between Depression and Cognitive Deterioration in Elderly Persons

The Relationship Between Depression and Cognitive Deterioration in Elderly Persons

Cognitive Impairment and Neurocognitive Profiles in Major Depression—A Clinical Perspective

Depression and Cognitive Impairment in Institutionalized Older Adults

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