Examining the gateway to the limbic system with diffusion tensor imaging: The perforant pathway in dementia

Kalus, Peter; Slotboom, Johannes; Gallinat, Jürgen; Mahlberg, Richard; Cattapan-Ludewig, Katja; Wiest, Roland; Nyffeler, Thomas; Buri, Caroline; Federspiel, Andrea; Kunz, Dieter; Schroth, Gerhard; Kiefer, Claus

doi:10.1016/j.neuroimage.2005.10.035

Cited by 103 publications

(89 citation statements)

References 49 publications

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“…Several studies, by use of manual VOI positioning or voxel-based morphometry techniques, have indicated that patients with MCI as a group showed atrophy of mesial temporal structures similar to those characteristic of AD. 5,41 However, no significant differences between patients with MCI and healthy elderly control subjects were reported in the mesial temporal lobe GM in voxel-based morphometry studies based on smaller cohorts that used restrictive statistical thresholds 42,43 or that considered age and Mini-Mental State Examination as nuisance variables. 44 Isolated decrease of GM volume in the left middle frontal gyrus was reported in a previous voxelbased morphometry study when comparing patients with amnestic MCI and healthy control subjects.…”

Section: Discussionmentioning

confidence: 99%

Regional Analysis of the Magnetization Transfer Ratio of the Brain in Mild Alzheimer Disease and Amnestic Mild Cognitive Impairment

Mascalchi¹,

Ginestroni²,

Bessi

et al. 2013

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Regional Analysis of the Magnetization Transfer Ratio of the Brain in Mild Alzheimer Disease and Amnestic Mild Cognitive Impairment

Mascalchi¹,

Ginestroni²,

Bessi

et al. 2013

AJNR Am J Neuroradiol

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“…In MCI subjects, disruptions of white matter integrity were mainly reported for limbic fiber tracts with direct connections to medial temporal lobe structures, including the posterior and parahippocampal cingulum, the perforant path, the fornix, and the uncinate fasciculus (Fellgiebel et al, 2005;Kalus et al, 2006;Sexton et al, 2010;Zhang et al, 2007).…”

Section: Structural Disconnection In the Course Of Admentioning

confidence: 99%

Measuring Cortical Connectivity in Alzheimer’s Disease as a Brain Neural Network Pathology: Toward Clinical Applications

Teipel

Grothe

Zhou

et al. 2016

J Int Neuropsychol Soc

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Objectives: The objective was to review the literature on diffusion tensor imaging as well as resting-state functional magnetic resonance imaging and electroencephalography (EEG) to unveil neuroanatomical and neurophysiological substrates of Alzheimer's disease (AD) as a brain neural network pathology affecting structural and functional cortical connectivity underlying human cognition. Methods: We reviewed papers registered in PubMed and other scientific repositories on the use of these techniques in amnesic mild cognitive impairment (MCI) and clinically mild AD dementia patients compared to cognitively intact elderly individuals (Controls). Results: Hundreds of peer-reviewed (cross-sectional and longitudinal) papers have shown in patients with MCI and mild AD compared to Controls (1) impairment of callosal (splenium), thalamic, and anterior-posterior white matter bundles; (2) reduced correlation of resting state blood oxygen level-dependent activity across several intrinsic brain circuits including default mode and attention-related networks; and (3) abnormal power and functional coupling of resting state cortical EEG rhythms. Clinical applications of these measures are still limited. Conclusions: Structural and functional (in vivo) cortical connectivity measures represent a reliable marker of cerebral reserve capacity and should be used to predict and monitor the evolution of AD and its relative impact on cognitive domains in pre-clinical, prodromal, and dementia stages of AD. (JINS, 2016, 22, 138-163)

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“…Scheff et al [37] reported that the number of synapses receiving EC input in the outer molecular layer of the DG was reduced in elderly subjects who had mild cognitive impairment compared with cognitively intact elderly subjects, and the extent of synapse reduction correlated with memory ability. Furthermore, the use of diffusion-tensor imaging, a new magnetic-resonance imaging (MRI) technique, has revealed a marked atrophy in the perforant path of aged memory-impaired humans compared with young ones [38].…”

Section: Reduced Connections From the Ec To The Hippocampusmentioning

confidence: 99%

Neurocognitive aging: prior memories hinder new hippocampal encoding

Wilson

Gallagher

Eichenbaum

et al. 2006

Trends in Neurosciences

305

327

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Normal aging is often accompanied by impairments in forming new memories, and studies of aging rodents have revealed structural and functional changes to the hippocampus that might point to the mechanisms behind such memory loss. In this article, we synthesize recent neurobiological and neurophysiological findings into a model of the information-processing circuit of the aging hippocampus. The key point of the model is that small concurrent changes during aging strengthen the auto-associative network of the CA3 subregion at the cost of processing new information coming in from the entorhinal cortex. As a result of such reorganization in aged memory-impaired individuals, information that is already stored would become the dominant pattern of the hippocampus to the detriment of the ability to encode new information.

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Examining the gateway to the limbic system with diffusion tensor imaging: The perforant pathway in dementia

Cited by 103 publications

References 49 publications

Regional Analysis of the Magnetization Transfer Ratio of the Brain in Mild Alzheimer Disease and Amnestic Mild Cognitive Impairment

Regional Analysis of the Magnetization Transfer Ratio of the Brain in Mild Alzheimer Disease and Amnestic Mild Cognitive Impairment

Measuring Cortical Connectivity in Alzheimer’s Disease as a Brain Neural Network Pathology: Toward Clinical Applications

Neurocognitive aging: prior memories hinder new hippocampal encoding

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