Examining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length

Cheng, Yuan-Yuei; Kao, Tung‐Wei; Chang, Yaotsu; Wu, Chen‐Jung; Peng, Tao‐Chun; Wu, Liwei; Yang, Hui‐Fang; Liaw, Fang‐Yih; Chen, Wei‐Liang

doi:10.1371/journal.pone.0180687

Cited by 39 publications

(36 citation statements)

References 47 publications

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“…Our finding of a linear descending trend of SOD activity across the sequential increase of the MS component number is in line with the observation of a previous investigation [33]. LTL and mtDNAcn have also been reported to exhibit such a linear descending trend previously [13,34]; however, we failed to observe a linear trend of these cellular aging markers. In the present study, we observed a significant negative correlation between SOD activity and TG as well as blood glucose indicators (HbA1c, FPG, and 2hPG); however, the absence of correlations of cellular aging markers and OS markers with other MS-related metabolic indicators such as BMI, WC, BP, and HDL-C disaccords with the previous findings [28,33,35].…”

supporting

confidence: 93%

Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

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The interplays of cellular aging and oxidative stress (OS) markers form a complex network, which has been reported to be interrelated with numerous age-related and metabolic diseases, including metabolic syndrome (MS). However, given the multifactorial mechanisms of MS, several important confounders such as dietary factors and the reciprocal effect among these markers have not been considered and adjusted in previous investigations regarding the associations of cellular aging and OS markers with MS and its related metabolic abnormalities. To explicate this, we conducted a cross-sectional study among 533 Chinese adults. All the participants underwent a 75 g oral glucose tolerance test. Dietary data were collected via a 24-hour dietary recall and subsequently analyzed by a registered dietitian using nutrition calculation software. Clinical diagnosis of MS was made according to the revised National Cholesterol Education Program Adult Treatment Panel III criteria (2004) with waist circumference cutoff modified for an Asian population. The leukocyte telomere length, mitochondrial DNA copy number, 8-hydroxy-2-deoxyguanosine, superoxide dismutase (SOD) activity, and glutathione reductase were examined. SOD activity was significantly decreased in MS subjects (62.06±16.89 U/mL vs. 56.25±22.61 U/mL, P=0.001) and exhibited a descending trend across sequential increase of MS component number (P for trend=0.031). SOD activity is modestly correlated with glucose indicators and insulin sensitivity and β-cell function indices and was independently and negatively correlated with the level of triglyceride. An independent association between SOD activity and MS was observed after adjusting for metabolic indicators, dietary factors, cellular aging, and OS markers, as well as insulin sensitivity and β-cell function indices. However, the statistical significance of the association between SOD activity and MS was attenuated after adjusting for the Matsuda insulin sensitivity index (ISIM) and insulin secretion-sensitivity index-2 (ISSI-2), suggesting a possible mediating effect. Therefore, we conducted a mediation model analysis, which showed that decreased ISIM and ISSI-2 partially and synergistically mediated the contribution of decreased SOD activity to MS. In conclusion, decreased SOD activity is an independent predictor for increased risk of MS, and insulin resistance and β-cell dysfunction partially mediate the relationship between decreased SOD activity and MS.

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supporting

confidence: 93%

Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction

Liu

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Shorter rLTL in peripheral blood has recently been proposed to be strongly associated with metabolic syndrome, especially in the female population [45]. Likewise, in a longitudinal study reported by Lee et al [46], rLTL in peripheral blood was shorter in an obese population.…”

Section: Discussionmentioning

confidence: 85%

The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking

Andersson

Degerman

Dahlin

et al. 2018

Cancer Causes Control

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Purpose Previous studies have suggested an association between relative leukocyte telomere length (rLTL) and glioma risk. This association may be influenced by several factors, including allergies, BMI, and smoking. Previous studies have shown that individuals with asthma and allergy have shortened relative telomere length, and decreased risk of glioma. Though, the details and the interplay between rLTL, asthma and allergies, and glioma molecular phenotype is largely unknown. Methods rLTL was measured by qPCR in a Swedish population-based glioma case-control cohort (421 cases and 671 controls). rLTL was related to glioma risk and health parameters associated with asthma and allergy, as well as molecular events in glioma including IDH1 mutation, 1p/19q co-deletion, and EGFR amplification. Results Longer rLTL was associated with increased risk of glioma (OR = 1.16; 95% CI 1.02-1.31). Similar to previous reports, there was an inverse association between allergy and glioma risk. Specific, allergy symptoms including watery eyes was most strongly associated with glioma risk. High body mass index (BMI) a year prior diagnosis was significantly protective against glioma in our population. Adjusting for allergy, asthma, BMI, and smoking did not markedly change the association between longer rLTL and glioma risk. rLTL among cases was not associated with IDH1 mutation, 1p/19q codeletion, or EGFR amplification, after adjusting for age at diagnosis and sex. Conclusions In this Swedish glioma case-control cohort, we identified that long rLTL increases the risk of glioma, an association not confounded by allergy, BMI, or smoking. This highlights the complex interplay of the immune system, rLTL and cancer risk.Keywords Glioma · Relative leukocyte telomere length (rLTL) · Allergy · BMI · Smoking · IDH1 · 1p/19q · EGFR Electronic supplementary material The online version of this article (https ://doi.

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“…Third, and possibly the most important, yet commonly misunderstood, is the role that estrogen-related signaling within the female myocardium plays in disease progression and/or protection. Finally, a strong correlation is reported between the leukocyte telomere length (LTL) shortening and increase in metabolic syndrome components in females ( Cheng et al, 2017 ). LTL shortening and low telomerase activity are shown to be associated with CVD, coronary artery disease, diabetes mellitus, cardiomyopathy, and all-cause mortality ( Bar et al, 2014 ; Yeh and Wang, 2016 ; Sawhney et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Diabetic Cardiomyopathy: Impact of Biological Sex on Disease Development and Molecular Signatures

2018

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Diabetic cardiomyopathy refers to a unique set of heart-specific pathological variables induced by hyperglycemia and insulin resistance. Given that cardiovascular disease (CVD) is the leading cause of death in the world, and type 2 diabetes incidence continues to rise, understanding the complex interplay between these two morbidities and developing novel therapeutic strategies is vital. Two hallmark characteristics specific to diabetic cardiomyopathy are diastolic dysfunction and cardiac structural mal-adaptations, arising from cardiac cellular responses to the complex toxicity induced by hyperglycemia with or without hyperinsulinemia. While type 2 diabetes is more prevalent in men compared to women, cardiovascular risk is higher in diabetic women than in diabetic men, suggesting that diabetic women take a steeper path to cardiomyopathy and heart failure. Accumulating evidence from randomized clinical trials indicate that although pre-menopausal women have lower risk of CVDs, compared to age-matched men, this advantage is lost in diabetic pre-menopausal women, which suggests estrogen availability does not protect from increased cardiovascular risk. Notably, few human studies have assessed molecular and cellular mechanisms regarding similarities and differences in the progression of diabetic cardiomyopathy in men versus women. Additionally, most pre-clinical rodent studies fail to include female animals, leaving a void in available data to truly understand the impact of biological sex differences in diabetes-induced dysfunction of cardiovascular cells. Elegant reviews in the past have discussed in detail the roles of estrogen-mediated signaling in cardiovascular protection, sex differences associated with telomerase activity in the heart, and cardiac responses to exercise. In this review, we focus on the emerging cellular and molecular markers that define sex differences in diabetic cardiomyopathy based on the recent clinical and pre-clinical evidence. We also discuss miR-208a, MED13, and AT2R, which may provide new therapeutic targets with hopes to develop novel treatment paradigms to treat diabetic cardiomyopathy uniquely between men and women.

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Examining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length

Cited by 39 publications

References 47 publications

Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction

Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction

The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking

Diabetic Cardiomyopathy: Impact of Biological Sex on Disease Development and Molecular Signatures

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