Parental perfectionism (e.g., perfectionistic concerns) has been strongly implicated in adolescent psychological maladjustment such as depression and anxiety. However, little is known about the links between parental perfectionistic self-presentation (i.e., the interpersonal expressions of perfectionism) and adolescent psychological outcomes. According to the Perfectionism Social Disconnection Model (Hewitt et al., 2017), people with elevated perfectionistic self-presentation engage in social behaviors characterized by a lack of emotional sensitivity or responsiveness, which then increases one’s risk of social disconnection and psychological maladjustment. This theory has seldom been tested in the context of parent-adolescent and family relationships. Therefore, this cross-sectional study aimed to explore the mediational role of familial affective responsiveness in the associations between parental perfectionistic self-presentation and adolescent psychological outcomes. Participants were 58 dyads of clinically depressed adolescents (Mage = 15.52; 74.5% female) and their primary caregivers (Mage = 46.08; 51 mothers). Path analysis indicated that the overall model fit the data well. Congruent with the Perfectionism Social Disconnection Model, analyses showed that adolescent but not parent-reported family dysfunction in affective responsiveness mediated the relations between parental perfectionistic self-presentation and adolescent depressive symptoms, suicidal ideation, and alcohol-related problems, even after controlling for parental depression. Taken together, our findings provide new information for the role of parental perfectionistic self-presentation in adolescent psychological maladjustment and highlight parental perfectionistic self-presentation as a potential target for therapeutic intervention in adolescent depression.