2015
DOI: 10.1038/srep12899
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Examining the safety of respiratory and intravenous inoculation of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus in a mouse model

Abstract: Bdellovibrio spp. and Micavibrio spp. are Gram-negative predators that feed on other Gram-negative bacteria, making predatory bacteria potential alternatives to antibiotics for treating multi-drug resistant infections. While the ability of predatory bacteria to control bacterial infections in vitro is well documented, the in vivo effect of predators on a living host has yet to be extensively examined. In this study, respiratory and intravenous inoculations were used to determine the effects of predatory bacter… Show more

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Cited by 62 publications
(87 citation statements)
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“…The lack of toxicity due to inoculation with predatory bacteria is in agreement with previous studies demonstrating the safety of introducing predatory bacteria in a variety of animal models (16–19). In particular, we observed similar results in our previous study, in which C57BL/6 mice were intranasally inoculated with high concentrations of viable or heat-killed B. bacteriovorus or M. aeruginosavorus (19).…”
Section: Discussionsupporting
confidence: 91%
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“…The lack of toxicity due to inoculation with predatory bacteria is in agreement with previous studies demonstrating the safety of introducing predatory bacteria in a variety of animal models (16–19). In particular, we observed similar results in our previous study, in which C57BL/6 mice were intranasally inoculated with high concentrations of viable or heat-killed B. bacteriovorus or M. aeruginosavorus (19).…”
Section: Discussionsupporting
confidence: 91%
“…Our results seen with the rat model align with our previous study, where intranasal or intravenous inoculation of high doses of either B. bacteriovorus or M. aeruginosavorus in mice caused no tissue pathology and induced only a modest inflammatory response that returned to baseline levels within 24 h postinoculation (19). Furthermore, predatory bacteria were completely cleared from the animals by an innate immune response (possibly via neutrophils) within 48 h postinoculation (19).…”
Section: Discussionsupporting
confidence: 91%
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