Excess Body Weight and Gastroesophageal Reflux Disease

Thalheimer, Andreas; Bueter, Marco

doi:10.1159/000516050

Cited by 16 publications

(18 citation statements)

References 48 publications

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“…The development of a hiatal hernia is the main factor that disrupts the integrity of the EGJ in patients with excess body weight [9]. The prevalence of hiatal hernia is Gastroesophageal Reflux Disease and Obesity DOI: http://dx.doi.org/10.5772/intechopen.106528 significantly higher in subjects with obesity than in subjects with a normal BMI [18]. The physiological explanation for the interplay between obesity, risk for hiatal hernia, and subsequent development of GERD was thoroughly explored in a manometry study conducted by Pandolfino et al [19].…”

Section: Pathophysiology Of Gerd In Obesitymentioning

confidence: 99%

Gastroesophageal Reflux Disease and Obesity

Wibawa¹,

Dharmesti²

2023

Gastroesophageal Reflux Disease - A Growing Concern

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The global rise of gastroesophageal reflux disease (GERD) prevalence makes it one of the most common diagnoses performed in a daily practice. Obesity significantly contribute to GERD development, accordingly, it has accounted for the increasing cases of GERD. Obesity can disrupt the esophagogastric junction integrity, which promote the development of GERD and its complication. The frequency of GERD symptoms and its mucosal complications also found more often in obesity. The parallel increase of both condition has initiated numerous studies to determine the most beneficial therapeutic options in managing this challenging condition. Current available therapy for GERD in obesity including weight reduction, pharmacotherapy, and surgery.

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Section: Pathophysiology Of Gerd In Obesitymentioning

confidence: 99%

Gastroesophageal Reflux Disease and Obesity

Wibawa¹,

Dharmesti²

2023

Gastroesophageal Reflux Disease - A Growing Concern

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“…Both approaches are based on assumptions [ 13 ]. Hiatus hernia in obese individuals causes disturbances in the integrity of GEJ, thus aggravating reflux [ 20 ]. Obesity may cause humoral changes such as changes in leptin and insulin levels and hormonal changes such as changes in estrogen levels, which indirectly cause GERD [ 7 ].…”

Section: Reviewmentioning

confidence: 99%

Role of Non-pharmacological Interventions and Weight Loss in the Management of Gastroesophageal Reflux Disease in Obese Individuals: A Systematic Review

Mukhtar¹,

Alzubaidee²,

Dwarampudi³

et al. 2022

Cureus

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With the increasing prevalence of obesity, the worldwide risk of gastroesophageal reflux disease (GERD) has also increased. Abdominal obesity increases intragastric pressure, disturbing the integrity of the gastroesophageal junction, thus facilitating reflux. Other than obesity, some lifestyle factors also cause GERD, including smoking, consumption of alcohol and caffeine, late-night meals, and high fat intake. This review study aimed to assess the impact of weight loss and lifestyle modifications on GERD. In this systematic review, the databases used were PubMed, PubMed Central (PMC), Science Direct, and Google Scholar. Boolean system and Medical Subject Headings (MeSH) strategy were used to form suitable keywords. Patients from the pediatric and geriatric populations were excluded from the study and quality assessment was done using different assessment tools. A positive association between obesity and GERD was found. It was also found that the long-term use of proton pump inhibitors (PPIs) causes complications, so lifestyle interventions should be used more than PPIs for treating GERD, especially in obese patients. We concluded that weight loss could lead to the resolution of gastroesophageal reflux disease, and therefore, conservative measures, including dietary modifications such as reducing the consumption of alcohol, caffeine, and chocolate, behavioral changes such as smoking cessation and elevation of the head of the bed, and weight loss, should be used as first-line management for GERD. Although awareness has increased regarding the adverse effects of proton pump inhibitors, future studies are required to assess these negative effects.

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“…Cependant, la réduction pondérale, indépendamment de ses autres effets bénéfiques, doit être obtenue car elle peut corriger à elle seule les facteurs physiopathologiques à l'origine des reflux (notamment la fréquence de survenue des RTSIO) 44 . La chirurgie seule ne constitue pas une bonne option de prise en charge des patients obèses avec RGO si elle n'est pas accompagnée d'une perte conséquente de poids 45 . Chez le sujet en surpoids, les résultats de la chirurgie ne semblent pas significativement modifiés par rapport aux sujets de poids normaux 46 .…”

Section: Sujets Répondeurs Au Traitement Médicalunclassified

Gastro-œsophageal reflux disease and surgery

Belhocine¹,

Varannes²

2022

Rev Med Brux

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Le reflux gastro-oesophagien (RGO) est une pathologie fréquente, ubiquitaire, représentant un véritable problème de santé publique dans certaines régions du monde. Sa prise en charge a été révolutionnée par l'avènement de molécules au fort potentiel anti-sécrétoire acide que sont les inhibiteurs de la pompe à protons. Néanmoins, la chirurgie anti-reflux réalisée par voie laparoscopique demeure une alternative thérapeutique, non négligeable, aux résultats très satisfaisants dans les centres experts mais non dépourvue d'échecs ou de morbidité. Cette revue de la littérature a pour objectif de synthétiser les indications adéquates et de préciser les caractéristiques des candidats rigoureusement sélectionnés afin de garantir un succès et une satisfaction élevés de cette chirurgie anti-reflux.

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Excess Body Weight and Gastroesophageal Reflux Disease

Cited by 16 publications

References 48 publications

Gastroesophageal Reflux Disease and Obesity

Gastroesophageal Reflux Disease and Obesity

Role of Non-pharmacological Interventions and Weight Loss in the Management of Gastroesophageal Reflux Disease in Obese Individuals: A Systematic Review

Gastro-œsophageal reflux disease and surgery

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