Excess Body Weight and Pancreatic Disease

Wiese, M; Aghdassi, Ali A.; Lerch, Markus M.; Steveling, Antje

doi:10.1159/000517147

Cited by 6 publications

(4 citation statements)

References 72 publications

(56 reference statements)

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“…Obesity is a chronic, relapsing, progressive condition, that is characterized by an abnormal or excessive accumulation of white adipose tissue [ 206 ]. It is associated with dysfunctions across several organ systems, including adipose tissue [ 13 ], gut [ 207 ], pancreas [ 208 ], and the brain [ 209 ]. Obesity contributes to premature disability and death by increasing the risk of several diseases [ 12 ], including T2D, CVD, some cancers, and neuropsychiatric disorders.…”

Section: Obesity and Cachexia: Pathogenesis And Related Microbiota Al...mentioning

confidence: 99%

Microbiota and body weight control: Weight watchers within?

Boscaini

Leigh

Lavelle

et al. 2022

Molecular Metabolism

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Section: Obesity and Cachexia: Pathogenesis And Related Microbiota Al...mentioning

confidence: 99%

Microbiota and body weight control: Weight watchers within?

Boscaini

Leigh

Lavelle

et al. 2022

Molecular Metabolism

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“…Alimentary obesity (AO) is a risk factor for the development of many pathophysiological conditions in various organs, including the pancreas [4]. Recently, the term "non-alcoholic fatty pancreas disease" (NAFPD) has been introduced, which leads to the development of steatopancreatitis, and subsequently to pancreatic oncology [5,6].…”

Section: Introductionmentioning

confidence: 99%

Role of Potassium Channel Trek-1 in Mechanosensitivity of Smooth Muscle Cells From Rat Detrusor

Yeliashov,

Sharopov,

Shuba

2024

Fiziol Zh

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Currently, TREK-1 is considered to be the main mechanosensitive channel in detrusor smooth muscle (DSM) cells. The aim of our study was to detect the functioning of the K+-conducting mechanosensitive TREK-1 channel in rat DSM cells using the patch-clamp technique in response to hydrodynamic stimulation (shear stress) and to determine the effects of a TREK-1 agonist – arachidonic acid (AA) and an antagonist – L-methionine. Mechanical stimulation of DSM cells using hydrodynamic stress led to the appearance of a membrane current with signs of pronounced outward rectification at positive membrane potentials, which is typical of TREK-1 activation. The application of AA (50 mcmol/l) activated a current with similar characteristics of the outward rectification to the shear stress-activated one. L-methionine (10 mcmol/l) almost completely prevented the generation of an outwardly rectifying current in response to shear stress stimulation. DSM cells also retained the ability to generate a mechanoactivated current with a more pronounced inward component when extracellular and intracellular K+ were replaced by Cs+. It was concluded that the dominant mechanoactivated current in rat DSM cells is carried by K+-selective TREK-1 channels, but a small portion of this current can also be carried by other nonselective mechanosensitive cation channels.

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Section: Introductionmentioning

confidence: 99%

L-tryptophan effectively prevents fatty degeneration of rat pancreas

Yanko,

Chaka,

Levashov

2024

Fiziol Zh

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Alimentary obesity is a risk factor for the development of many pathophysiological conditions in various organs, including the pancreas. Thus, the study of mechanisms, clinical symptoms and ways to prevent the development of fatty degeneration of pancreas at obesity is a current direction of research. The aim of our work was to study the influence of L-tryptophan on the morphofunctional changes of the pancreas of rats with diet-induced obesity and to evaluate the possibility of its use for the prevention of the development of the gland fatty degeneration. The study was conducted in male Wistar rats, which were 3 months old at the experiment beginning. Histologic preparations were made from pancreas tissue samples using a standard method. Morphometric measurements were performed on digital images using “Image J” software. In biochemical studies, we determined concentration of glucose in blood serum and of triglycerides, lipids and cholesterol in pancreas tissue samples. It was found that rats fed a high-fat, high-carbohydrate diet showed marked sings of developing alimentary obesity. This was evidenced by a significant increase in the weight of visceral fat (by 147%) and obesity index (by 129%). The exposure of rats to a high-calorie diet resulted in the emergence of distinct signs indicating hypofunction in both the exocrine and, to a greater extent, endocrine sections of the pancreas. The administration of L-tryptophan reduced the intensity of accumulation of visceral fat and fat in the gland itself. This was evidenced by lower concentrations of lipids (by 53%) and triglycerides (by 32%) in the pancreatic tissue compared to high-calorie diet rats. In addition, L-tryptophan prevented an excessive decrease in the function of both the exocrine and endocrine parts of the gland from the harmful effects of dietary obesity. This may be of practical interest when using tryptophan and its derivatives in the clinic to prevent a decrease in gland activity in this pathology.

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Excess Body Weight and Pancreatic Disease

Cited by 6 publications

References 72 publications

Microbiota and body weight control: Weight watchers within?

Microbiota and body weight control: Weight watchers within?

Role of Potassium Channel Trek-1 in Mechanosensitivity of Smooth Muscle Cells From Rat Detrusor

L-tryptophan effectively prevents fatty degeneration of rat pancreas

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