2018
DOI: 10.1016/j.domaniend.2018.05.006
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Excess deposition of collagen in mammary glands of tamoxifen-treated Holstein heifers is associated with impaired mammary growth

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Cited by 4 publications
(4 citation statements)
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“…Given the ability of Tmx to modulate ECM deposition, 20,26,27 and the impact of altered ECM on tendon function, we examined the effects of Tmx and CO pretreatment (WO) and sustained treatment (D0‐2q48) on gliding function. No changes in MTP flexion angle (Figure 4A) or GR (Figure 4B) were observed between Tmx‐ or CO‐treated tendon repairs from female mice, for both the WO and D0‐2q48 regimens.…”
Section: Resultsmentioning
confidence: 99%
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“…Given the ability of Tmx to modulate ECM deposition, 20,26,27 and the impact of altered ECM on tendon function, we examined the effects of Tmx and CO pretreatment (WO) and sustained treatment (D0‐2q48) on gliding function. No changes in MTP flexion angle (Figure 4A) or GR (Figure 4B) were observed between Tmx‐ or CO‐treated tendon repairs from female mice, for both the WO and D0‐2q48 regimens.…”
Section: Resultsmentioning
confidence: 99%
“…The role of Tmx in extracellular matrix deposition and tissue fibrosis is strongly context‐dependent. For example, Tucker et al, 20 demonstrated that Tmx treatment doubled collagen deposition in the mammary stroma, resulting in altered ductal morphogenesis. In contrast, Tmx treatment was protective against renal fibrosis development following unilateral ureteral obstruction, with decreases in fibroblast activation and ECM deposition 27 .…”
Section: Discussionmentioning
confidence: 99%
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“…Interestingly, casein production is higher in bovine MECs seeded on floating collagen gels than on attached collagen gels [ 118 ]. In addition, excess deposition of type I collagen in mammary glands causes impaired mammary morphogenesis in cows [ 119 ]. However, it remains unclear whether and how much MECs contact with fibrillar collagens in vivo because the MECs are directly enclosed in basement membrane.…”
Section: Overview Of Mec Culture Modelsmentioning
confidence: 99%