Excess Mortality Related to Alcohol and Smoking Among Hospital-Treated Patients With Psoriasis

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

“…58 Lastly, higher mortality secondary to alcohol-related disease was seen in patients admitted to the hospital for moderate to severe psoriasis. 59 One study has shown higher rates of deaths from cirrhosis in psoriatics who drank at least moderately and had not been exposed to methotrexate. 14 However, others have demonstrated a lack of statistical significance, 60 especially after controlling for confounders such as smoking.…”

Cancer risk in hospitalised psoriasis patients: a follow-up study in Sweden

“…The magnitude of alcohol and/ or smoking effects on psoriasis has been evaluated in many earlier studies, but the data were heterogeneous because most of them were limited by small sample sizes (Schafer, 2006). In a recent population-based study involved 5687 hospitalised psoriasis patients in Finland (Poikolainen et al, 1999), where the health care system and diagnosed criteria were similar to Sweden, the mortality for alcohol and smoking-related causes was significantly increased among these patients compared with general population, with a standardised mortality ratio of 2.14 (men) and 1.47 (women) for alcohol-related causes and 1.44 (men) and 1.61 (women) for smoking-related causes, respectively. For these alcohol and smoking-related cancer sites, the risks were somewhat higher in female patients, with an exception of liver cancer, suggesting that stress could be related to the association between psoriasis and smoking and alcohol consumption.…”

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

“…69 In one lesser quality review of over 6,000 hospitalized patients with psoriasis, the majority of deaths were alcohol-related. 70 The study was limited by lack of adequate comparison groups and exclusion of patients with other comorbidities associated with increased alcohol intake. Patients with psoriasis had higher rates of alcohol consumption than controls.…”