Excess weight in preschool children with a history of severe bronchiolitis is associated with asthma

Törmänen, Sari; Lauhkonen, Eero; Saari, Antti; Koponen, Petri; Korppi, Matti; Nuolivirta, Kirsi

doi:10.1002/ppul.23053

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…We found that only an early or late high BMI did not increase the risk of school-age asthma, but a persistently high BMI from infancy to school age increased the risk. However, some studies have reported an association between asthma and only current overweight (6–8). Other studies have found associations between overweight in early childhood and subsequent asthma.…”

Section: Discussionmentioning

confidence: 99%

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A persistently high body mass index increases the risk of atopic asthma at school age

et al. 2015

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AimBeing overweight has been associated with the risk of developing childhood asthma, but studies have produced conflicting results, for example with regard to possible links to allergic diseases. This study aimed to explore the relationship between body mass index (BMI) and school-age asthma.MethodsData were obtained from a prospective, longitudinal study of 5044 children born in western Sweden. The parents answered questionnaires at six months and one, four-and-a-half and eight years of age. The response rate to the final questionnaire at the age of eight was just over 80%. BMI was adjusted for age and gender, and a high BMI was defined as the 85th percentile and above.ResultsA multivariate analysis showed an independently increased risk of doctor-diagnosed asthma among children with a persistently high BMI, both in infancy and at school age, with an adjusted odds ratio (aOR) of 2.9 and a 95% confidence interval (CI) of 1.3–6.4. In addition, persistently high BMI was associated with an increased risk of atopic asthma (aOR 4.7, 95% CI 2.0–11.0).ConclusionA persistently high BMI during childhood increased the risk of doctor-diagnosed asthma at school age. The increased risk of atopic asthma suggests an effect mediated via the immune system.

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Section: Discussionmentioning

confidence: 99%

“…Some studies only report an association between current overweight and asthma (6–8). Other studies have reported that early overweight (9) or rapid growth during the first two years of life (10) is associated with an increased risk of later wheeze or asthma.…”

Section: Introductionmentioning

confidence: 99%

A persistently high body mass index increases the risk of atopic asthma at school age

et al. 2015

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“…Thus, optimized care following bronchiolitis and elimination of smoke exposure could improve long‐term outcomes. The post‐bronchiolitis risk of recurrent wheeze/asthma is modified by gender, with an increased risk in boys, by excess weight at school age, but not by birth weight or excess weight in the first 1.5 years of life, and by polymorphisms in the TLR4, CD14, and IL‐13 genes …”

Section: Respiratory Infectionmentioning

confidence: 99%

Pediatric Pulmonologyyear in review 2015: Part 1

et al. 2016

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Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection.Word count: 71 3

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“…This finding is consistent with other recent reports and reviews . Obesity continues to show a relationship with asthma risk in children; Tormanen et al prospectively followed up children with bronchiolitis before age 6 months, and demonstrated that overweight at age 5–7 years was associated with preschool age asthma and current asthma, even after adjustment for other risk factors …”

Section: Asthmamentioning

confidence: 99%

Pediatric pulmonology year in review 2015: Part 3

et al. 2016

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Excess weight in preschool children with a history of severe bronchiolitis is associated with asthma

Abstract: Asthma was more common in currently overweight than in normal weight former bronchiolitis patients at preschool age and early school age.

Cited by 9 publications

References 31 publications

A persistently high body mass index increases the risk of atopic asthma at school age

A persistently high body mass index increases the risk of atopic asthma at school age

Pediatric Pulmonologyyear in review 2015: Part 1

Pediatric pulmonology year in review 2015: Part 3

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