Excessive Mortality and Causes of Death in Morbidly Obese Men

Drenick, Ernst J.

doi:10.1001/jama.1980.03300310031018

Cited by 346 publications

(70 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is a direct association between obesity and several diseases like diabetes mellitus, hypertension, dyslipidaemia and ischemic heart disease 25. Weight gain appears to precede the development of diabetes 26.…”

Section: Discussionmentioning

confidence: 99%

Frequency of obesity and comorbidities in medical students

Mehmood¹,

Alswailmi²,

Alenazi³

2016

Pak J Med Sci

View full text Add to dashboard Cite

Objectives:To determine the frequency of obesity disorders and their co-morbidities in medical students.Methods:This cross-sectional study was conducted in Faculty of Medicine, Northern Border University, Ar’ar, Saudi Arabia. All medical students who consented to participate were included in the study. Their relevant information was recorded on a structured proforma. Weight and height of the participants were measured using calibrated manual weighing scale and Body mass index (BMI) was calculated. The obtained results were interpreted according to classification of body weight disorders. The participants who turned out to be over-weight and obese were further assessed for hypertension, diabetes mellitus and gallstones. The collected data was analyzed using the Statistical Package for Social Science (SPSS) version 20.Results:A total of 405 students participated in study, age range was 19-25 years. Male were 169 (41.7%) and female students were 236(58.3%). Family history of obesity was present in 34.3%. Out of 405 students, 126 were having BMI between 25 and 45.6, among them 34(8.4%) students were obese and 88 (21.7%) were overweight. Sixty two (15.3%) among them were male and 64 (15.8%) female. Fourteen (11.1%) were hypertensive and 9(7.1%) were having gall stones.Conclusion:The frequency of obesity among medical students was 8.4%. Increasing frequency of obesity associated with unhealthy life style needs to be controlled at national level to raise a healthy generation and to reduce burden on health economy.

show abstract

Section: Discussionmentioning

confidence: 99%

Frequency of obesity and comorbidities in medical students

Mehmood¹,

Alswailmi²,

Alenazi³

2016

Pak J Med Sci

View full text Add to dashboard Cite

show abstract

“…Obesity is associated with an increased risk of coronary artery disease (CAD) and mortality [6-8]. Morbidity and mortality rates rise proportionally to the degree of obesity in men and women and the impact of excess body fat is more significant in younger subjects than older ones [9-12].…”

Section: Discussionmentioning

confidence: 99%

Metabolic and cardiovascular improvements after biliopancreatic diversion in a severely obese patient

Woods

Paquette

Martin

et al. 2004

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background: Severe obesity is associated with important morbidity and increased mortality. The successes of lifestyle modifications and drug therapy have been partial and mostly unsustained in reducing obesity and its comorbidities. Bariatric surgery, particularly biliopancreatic diversion with duodenal switch reduces efficiently excess body weight and improves metabolic and cardiovascular functions.

show abstract

“…In obese patients cardiomyopathies are manifested as longer P-wave, and increased QT c dispersion (Seyfeli et al, 2006; Nielsen et al, 2013b). Since altered QT c is also associated with sudden cardiac death (SCD), Drenick et al found that in obesity SCD is 12-fold higher in patients aged 25–34, and 6-fold higher in in age group 35–44 years (Drenick et al, 1980). On the other hand, Kannel et al found that there was no association between obesity and SCD (Kannel et al, 1998).…”

Section: Ionic Mechanisms Of Cardiomyopathies Of Obesitymentioning

confidence: 99%

Cardiac Ion Channel Regulation in Obesity and the Metabolic Syndrome: Relevance to Long QT Syndrome and Atrial Fibrillation

Aromolaran

Boutjdir

2017

Front. Physiol.

View full text Add to dashboard Cite

Obesity and its associated metabolic dysregulation leading to metabolic syndrome is an epidemic that poses a significant public health problem. More than one-third of the world population is overweight or obese leading to enhanced risk of cardiovascular disease (CVD) incidence and mortality. Obesity predisposes to atrial fibrillation, ventricular, and supraventricular arrhythmias; conditions that are underlain by dysfunction in electrical activity of the heart. To date, current therapeutic options for cardiomyopathy of obesity are limited, suggesting that there is considerable room for development of therapeutic interventions with novel mechanisms of action that will help normalize rhythm in obese patients. Emerging candidates for modulation by obesity are cardiac ion channels and Ca handling proteins. However, the underlying molecular mechanisms of the impact of obesity on these channels/Ca handling proteins remain incompletely understood. Obesity is marked by accumulation of adipose tissue associated with a variety of adverse adaptations including dyslipidemia (or abnormal levels of serum free fatty acids), increased secretion of pro-inflammatory cytokines, fibrosis, hyperglycemia, and insulin resistance, that will cause electrical remodeling and thus predispose to arrhythmias. Further, adipose tissue is also associated with the accumulation of subcutaneous and visceral fat, which are marked by distinct signaling mechanisms. Thus, there may also be functional differences in the outcome of regional distribution of fat deposits on ion channel/Ca handling proteins expression. Evaluating alterations in their functional expression in obesity will lead to progress in the knowledge about the mechanisms responsible for obesity-related arrhythmias. These advances are likely to reveal new targets for pharmacological modulation. The objective of this article is to review cardiac ion channel/Ca handling proteins remodeling that predispose to arrhythmias. Understanding how obesity and related mechanisms lead to cardiac electrical remodeling is likely to have a significant medical and economic impact.

show abstract

Excessive Mortality and Causes of Death in Morbidly Obese Men

Cited by 346 publications

References 6 publications

Frequency of obesity and comorbidities in medical students

Frequency of obesity and comorbidities in medical students

Metabolic and cardiovascular improvements after biliopancreatic diversion in a severely obese patient

Cardiac Ion Channel Regulation in Obesity and the Metabolic Syndrome: Relevance to Long QT Syndrome and Atrial Fibrillation

Contact Info

Product

Resources

About