2004
DOI: 10.1016/j.amjcard.2003.11.050
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Excimer laser angioplasty in acute myocardial infarction (the CARMEL multicenter trial)

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Cited by 120 publications
(68 citation statements)
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“…The patient reported by Daya et al [8] underwent emergency surgery due to left main thrombosis with acute ST segment elevation myocardial infarction and suffered acute pulmonary embolism in the early postoperative period. Knowing the success of excimer laser in the removal of extensive thrombus [9], we decided to treat our patient by laser. The case reported by Michalis et al underwent primary angioplasty for the totally occluded right coronary artery, and abciximab treatment for 5 days resulted in complete resolution of the thrombus seen in left main and LAD.…”
Section: Discussionmentioning
confidence: 99%
“…The patient reported by Daya et al [8] underwent emergency surgery due to left main thrombosis with acute ST segment elevation myocardial infarction and suffered acute pulmonary embolism in the early postoperative period. Knowing the success of excimer laser in the removal of extensive thrombus [9], we decided to treat our patient by laser. The case reported by Michalis et al underwent primary angioplasty for the totally occluded right coronary artery, and abciximab treatment for 5 days resulted in complete resolution of the thrombus seen in left main and LAD.…”
Section: Discussionmentioning
confidence: 99%
“…At first, the guiding ment of AMI by achieving maximum thrombus dissolution in lesions with extensive thrombus burden, significant increase in minimal luminal diameter, adequate restoration of antegrade Thrombolysis In Myocardial Infarction (TIMI) flow in the infarct-related artery, and a very low rate of distal embolization. 11 In the present study, we evaluated the safety and efficacy of ELCA as an adjunct to primary PCI in patients with ACS and compared the success rate, tissue-level perfusion, and shortterm outcomes following ELCA with those of manual thrombus aspiration.…”
Section: Pre-and Post-procedures Management and Pcimentioning
confidence: 99%
“…This wavelength is well absorbed within atherosclerotic material with a shallow penetration depth of only 35-50 mm [20] which enables precise control of energy and ensures debulking without plaque disintegration. In 151 patients with atherosclerotic/thrombotic coronary lesions, excimer laser debulking caused distal embolization in only 1 (0.6%) patient [21]. Importantly, the excimer laser facilitates removal of the thrombus which frequently accompanies atherosclerotic plaques.…”
Section: Discussionmentioning
confidence: 99%
“…This has been validated in patients with acute myocardial infarction or unstable angina pectoris whereby quantitative analysis by an independent core laboratory demonstrated 96% reduction of thrombus burden with the laser emission in the acute myocardial infarction group and 97% reduction in the unstable angina group [22]. Furthermore, it appears that the larger the thrombus content, the higher the yield of the laser as a thrombectomy device [21]. It also suppresses platelet aggregation (''stunned platelet phenomenon'' [23]) thereby reducing their adverse effect on the revascularization process.…”
Section: Discussionmentioning
confidence: 99%