Excitation-Contraction Coupling Regulation in Aging Skeletal Muscle

Delbono, Osvaldo

doi:10.1007/978-90-481-9713-2_6

Cited by 22 publications

(26 citation statements)

References 133 publications

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“…In fact, this study indicated that low lean mass in women was not associated with elevated mortality rates. (McLean, Shardell, Alley, Cawthon, Fragala, Harris, Kenny, Peters, Ferrucci, Guralnik, Kritchevsky, Kiel, Vassileva, Xue, Perera, Studenski, and Dam 2014) This suggests that at some level, there is a disconnect between muscle mass and weakness that may theoretically be explained by other factors such as age-dependent inter- and intramuscular fat infiltration (Goodpaster, Carlson, Visser, Kelley, Scherzinger, Harris, Stamm, and Newman 2001;Visser, Kritchevsky, Goodpaster, Newman, Nevitt, Stamm, and Harris 2002), excitation-contraction coupling, (Delbono 2000) or dysfunctions of the central nervous system or neuromuscular junctions. (Vandervoort 2002) In support of this, evidence suggests that neither the measurement of muscle mass nor muscle index (appendicular lean mass relative to BMI) is consistently associated with adverse outcomes.…”

Section: Discussionmentioning

confidence: 99%

Successful aging: Advancing the science of physical independence in older adults

Anton

Woods

Ashizawa

et al. 2015

Ageing Research Reviews

215

162

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The concept of ‘Successful Aging’ has long intrigued the scientific community. Despite this long-standing interest, a consensus definition has proven to be a difficult task, due to the inherent challenge involved in defining such a complex, multi-dimensional phenomenon. The lack of a clear set of defining characteristics for the construct of successful aging has made comparison of findings across studies difficult and has limited advances in aging research. The domain in which consensus on markers of successful aging is furthest developed is the domain of physical functioning. For example, walking speed appears to be an excellent surrogate marker of overall health and predicts the maintenance of physical independence, a cornerstone of successful aging. The purpose of the present article is to provide an overview and discussion of specific health conditions, behavioral factors, and biological mechanisms that mark declining mobility and physical function and promising interventions to counter these effects. With life expectancy continuing to increase in the United States and developed countries throughout the world, there is an increasing public health focus on the maintenance of physical independence among all older adults.

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Section: Discussionmentioning

confidence: 99%

Successful aging: Advancing the science of physical independence in older adults

Anton

Woods

Ashizawa

et al. 2015

Ageing Research Reviews

215

162

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“…This may affect the ability of aged muscle cells to modulate calcium release with muscle contraction. Thus, age-related changes in neuromuscular activation appear to largely contribute to declines in strength and power [73,74].…”

Section: Skeletal Muscular Changes Associated With Agingmentioning

confidence: 98%

Muscle Quality in Aging: a Multi-Dimensional Approach to Muscle Functioning with Applications for Treatment

2015

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Aging is often accompanied by declines in physical functioning which impedes older adults' quality of life, sense of independence, and ability to perform daily tasks. Age-related decreases in skeletal muscle quantity, termed sarcopenia, have traditionally been blamed for these physical decrements. However, recent evidence suggests that the quality of muscle tissue may be more functionally relevant than its quantity. 'Muscle quality' has been emerging as a means to elucidate and describe the intricate intramuscular changes associated with muscle performance in the context of aging and sarcopenia. While muscle quality has most commonly been defined in terms of muscle composition or relative strength, at the core, muscle quality really describes muscle's ability to function. Skeletal muscle displays a strong structure-function relationship by which several architectural characteristics factor into its functional capacity. This review describes the structural, physiological, and functional determinants of muscle quality at the tissue and cellular level, while also introducing other novel parameters such as sarcomere spacing and integrity, circulating biomarkers, and the muscle quality index. Muscle qualitative features are described from the perspective of how physical exercise may improve muscle quality in older adults. This broad, multidimensional perspective of muscle quality in the context of aging and sarcopenia offers comprehensive insights for consideration and integration in developing improved prognostic tools for research and clinical care, while also promoting translational approaches to the design of novel targeted intervention strategies designed to maintain function and mobility into late life.

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“…Previous studies have shown that decreased expression of the Ca v 1.1 subunit diminishes SR Ca 2+ release in muscle fibers from aging mice [11, 12], a process known as excitation-contraction uncoupling (ECU) [3]. ECU is partially due to increased Ca v 1a expression with aging [35].…”

Section: Introductionmentioning

confidence: 99%

Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice

Wang

Tang

Messi

et al. 2012

Pflugers Arch - Eur J Physiol

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Contrasting information suggests either almost complete depletion of sarcoplasmic reticulum (SR) Ca2+ or significant residual Ca2+ concentration after prolonged depolarization of the skeletal muscle fiber. The primary obstacle to resolving this controversy is the lack of genetically encoded Ca2+ indicators (GECI) targeted to the SR that exhibit low-Ca2+ affinity, a fast biosensor:Ca2+ off-rate reaction, and can be expressed in myofibers from adult and older adult mammalian species. This work used the recently designed low-affinity Ca2+ sensor (Kd=1.66 mM in the myofiber) CatchER (calcium sensor for detecting high concentrations in the ER) targeted to the SR, to investigate whether prolonged skeletal muscle fiber depolarization significantly alters residual SR Ca2+ with aging. We found CatchER a proper tool to investigate SR Ca2+ depletion in young-adult and older adult mice, consistently tracking SR luminal Ca2+ release in response to brief and repetitive stimulation. We evoked SR Ca2+ release in whole-cell voltage-clamped flexor digitorum brevis (FDB) muscle fibers from young and old FVB mice and tested the maximal SR Ca2+ release by directly activating the ryanodine receptor (RyR1) with 4-Chloro-m-cresol (4-CmC) in the same myofibers. Here, we report for the first time, that the Ca2+ remaining in the SR after prolonged depolarization (2s) in myofibers from aging (~220 µM) was larger than young (~132µM) mice. These experiments indicate that SR Ca2+ is far from fully depleted under physiological conditions throughout life, and support the concept of excitation-contraction uncoupling in functional senescent myofibers.

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Excitation-Contraction Coupling Regulation in Aging Skeletal Muscle

Cited by 22 publications

References 133 publications

Successful aging: Advancing the science of physical independence in older adults

Successful aging: Advancing the science of physical independence in older adults

Muscle Quality in Aging: a Multi-Dimensional Approach to Muscle Functioning with Applications for Treatment

Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice

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