Excitation function of proton induced nuclear reaction on strontium: Special relevance to the production of 88Y

Elbinawi, Alaa; Al-Abyad, M.; Bashter, I.I.; Seddik, U.; Ditrói, F.

doi:10.1016/j.apradiso.2018.07.031

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…very well with the values by Kettern et al [10] and Elbinawi et al [24] but not with Levkovskii [26] (cf. Appendix Figure 1).…”

Section: Discussionsupporting

confidence: 88%

“…Appendix Figure 1). A polynomial fit through the three concordant datasets [10,24], and [this work] gave the required curve for the yield calculation. The data for the 87 Sr(p,n) 87g Y reaction are shown in Appendix Figure 2.…”

Section: Discussionmentioning

confidence: 99%

“…[7,21,22]. Two measurements have been reported on nat Sr as target material [23,24] and three on enriched 86 Sr [8,25,26]. For high-purity production of 86 Y, the data on enriched 86 Sr are more relevant.…”

Section: Introductionmentioning

confidence: 99%

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Accurate determination of production data of the non-standard positron emitter ⁸⁶Y via the ⁸⁶Sr(p,n)-reaction

et al. 2020

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In view of several significant discrepancies in the excitation function of the 86Sr(p,n)86g+xmY reaction which is the method of choice for the production of the non-standard positron emitter 86Y for theranostic application, we carried out a careful measurement of the cross sections of this reaction from its threshold up to 16.2 MeV at Forschungszentrum Jülich (FZJ) and from 14.3 to 24.5 MeV at LBNL. Thin samples of 96.4% enriched 86SrCO3 were prepared by sedimentation and, after irradiation with protons in a stacked-form, the induced radioactivity was measured by high-resolution γ-ray spectrometry. The projectile flux was determined by using the monitor reactions natCu(p,xn)62,63,65Zn and natTi(p,x)48V, and the calculated proton energy for each sample was verified by considering the ratios of two reaction products of different thresholds. The experimental cross section data obtained agreed well with the results of a nuclear model calculation based on the code TALYS. From the cross section data, the integral yield of 86Y was calculated. Over the optimum production energy range Ep = 14 → 7 MeV the yield of 86Y amounts to 291 MBq/μA for 1 h irradiation time. This value is appreciably lower than the previous literature values calculated from measured and evaluated excitation functions. It is, however, more compatible with the experimental yields of 86Y obtained in clinical scale production runs. The levels of the isotopic impurities 87mY, 87gY, and 88Y were also estimated and found to be <2% in sum.

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“…very well with the values by Kettern et al [10] and Elbinawi et al [24] but not with Levkovskii [26] (cf. Appendix Figure 1).…”

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Accurate determination of production data of the non-standard positron emitter ⁸⁶Y via the ⁸⁶Sr(p,n)-reaction

et al. 2020

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“…will be prepared and published in a dedicated journal. [29,[34][35][36][37], proton induced reaction on 88 Sr target [29,[38][39][40] or proton induced reaction on natural strontium target [41][42][43] or deuteron induced reactions on nat Sr [44,45].…”

Section: Applications Of Deuteron Induced Reactions On Rubidium For Nuclear Medicinementioning

confidence: 99%

Activation cross section data of deuteron induced nuclear reactions on rubidium up to 50 MeV

et al. 2021

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Activation cross sections of the $$^{\mathrm {nat}}\hbox {Rb (d,xn)}^{87\mathrm {m,85m,85g,83,82}}\hbox {Sr}$$ nat Rb (d,xn) 87 m , 85 m , 85 g , 83 , 82 Sr , $$^{\mathrm {nat}}\hbox {Rb(d,x)}^{\mathrm {86,84,83,82m}}\hbox {Rb}$$ nat Rb(d,x) 86 , 84 , 83 , 82 m Rb and $$^{\mathrm {nat}}\hbox {Rb(d,x)}^{85\mathrm {m}}\hbox {Kr}$$ nat Rb(d,x) 85 m Kr nuclear reactions have been measured for the first time through an activation method combining the stacked foil irradiation technique and gamma-ray spectrometry. The provided cross sections from the present investigation are all new, in such a way contribute to the completeness of the experimental database. The experimental cross sections were compared with the theoretical prediction in the TENDL-2019 TALYS based library and with our calculation using ALICE-D and EMPIRE-D model codes in order the improve their predictivity. Thick target production yields were calculated form the new cross sections for all investigated radioisotopes. Practical applications of the results are shortly discussed.

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“…It requires about 14 MeV as higher energies increase the percentage of the contaminants. The reported irradiation of around 200 mg/cm 2 of the commercially available 95% enriched 86 SrCO3 target yields about 150 MBq/μAh with less than 3% of radioactive impurities (Rösch et al, 1993a(Rösch et al, ,1993bKettern et al, 2002;Yoo et al, 2005, Avila-Rodriguez et al, 2008, Lukić et al, 2009Elbinawi et al, 2018). For comparison, around 10 MBq of 86g Y is enough for in vivo mice studies (Lövqvist et al, 2001;McQuade et al, 2005).…”

Section: G Ymentioning

confidence: 99%

Radionuclide candidates for β+γ coincidence PET: An overview

Sitarz

Cussonneau

Matulewicz

et al. 2020

Applied Radiation and Isotopes

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Excitation function of proton induced nuclear reaction on strontium: Special relevance to the production of 88Y

Cited by 12 publications

References 22 publications

Accurate determination of production data of the non-standard positron emitter ⁸⁶Y via the ⁸⁶Sr(p,n)-reaction

Accurate determination of production data of the non-standard positron emitter ⁸⁶Y via the ⁸⁶Sr(p,n)-reaction

Activation cross section data of deuteron induced nuclear reactions on rubidium up to 50 MeV

Radionuclide candidates for β+γ coincidence PET: An overview

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Excitation function of proton induced nuclear reaction on strontium: Special relevance to the production of 88Y

Cited by 12 publications

References 22 publications

Accurate determination of production data of the non-standard positron emitter 86Y via the 86Sr(p,n)-reaction

Accurate determination of production data of the non-standard positron emitter 86Y via the 86Sr(p,n)-reaction

Activation cross section data of deuteron induced nuclear reactions on rubidium up to 50 MeV

Radionuclide candidates for β+γ coincidence PET: An overview

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Product

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Accurate determination of production data of the non-standard positron emitter ⁸⁶Y via the ⁸⁶Sr(p,n)-reaction

Accurate determination of production data of the non-standard positron emitter ⁸⁶Y via the ⁸⁶Sr(p,n)-reaction