Excitation functions and yields for 111In production using 113, 114,natCd(p,xn)111In reactions with 65 MeV protons

Zaitseva, N.G.; Knotek, O.; Kowalew, A.; Mikecz, Pál; Rurarz, E.; Khalkin, V.A.; Ageev, V. A.; Klyuchnikov, A.A.; Kuzina, L.A.; Linev, A.F.

doi:10.1016/0883-2889(90)90105-p

Cited by 27 publications

(22 citation statements)

References 19 publications

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“…The largest part of the available cross section values, published in [8,10,27,[31][32][33][34][35][36], was already documented in the recent compilation published by IAEA in 2011 [11]. Three additional studies ( [29,30] and this work) confirm the general behaviour of the excitation function.…”

Section: Cd(pn) 114m Insupporting

confidence: 81%

“…In the overlapping energy region a good agreement with the data of Tárkányi et al [ [29] and Al-Abyad [30] are also presented in the figure and are agreeing well. The three data points from Brought to you by | New York University Bobst Library Technical Services Authenticated Download Date | 6/1/15 1:20 PM the Zaitseva et al [31] study, obtained at the end of a long stack, show some energy shift.…”

Section: Cd(pn) 114m Inmentioning

confidence: 95%

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Production of ¹¹¹In and ^114mIn by proton induced reactions: an update on excitation functions, chemical separation – purification and recovery of target material

et al. 2014

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In order to update the recommended cross section data of IAEA for production of 111 In and 114m In through the 112 Cd(p,2n) and 114 Cd(p,n) reactions new measurements were performed. In stacked-foil irradiations with incident proton energy of 36.7 and 25 MeV on highly enriched 112 Cd and 114 Cd targets, the excitation functions for 109,110g,110m,111,113m,114m In were determined, relative to the monitor reactions nat Cu(p,x) 62,65 Zn. The results are compared with the available literature values (also extracted from measurements on nat Cd) and with data listed in the on-line library TENDL-2012 (calculated with the TALYS 1.4 theoretical code). The industrial, PC-controlled automated dissolution and separation chemistry apparatus for delivery of large quantities of nca 111 In and the recovery of enriched 112 Cd from processed irradiated targets are described. MotivationThe use of 111 In in diagnostic nuclear medicine has been known for a long time. It has favourable decay characteristics ( 1/2 = 2.805 d, 100% EC) and emits two intense -rays that are in the preferred energy range for SPECT. Since its early application in labelling of blood platelets [1], useful

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Section: Cd(pn) 114m Insupporting

confidence: 81%

Section: Cd(pn) 114m Inmentioning

confidence: 95%

Production of ¹¹¹In and ^114mIn by proton induced reactions: an update on excitation functions, chemical separation – purification and recovery of target material

et al. 2014

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“…Alternatively, 111 In is also produced by irradiation of a natural silver target with an energetic a-beam in a cyclotron according to the 109 Ag(a,2n) 111 In reaction. [33][34][35][36] Radiochemical separation of 111 In from the irradiated target can be performed using a large variety of techniques, such as coprecipitation with Fe(OH) 3 or La(OH) 3 , ion exchange, and extraction chromatography. Each of the techniques has its own advantages and disadvantages.…”

Section: Production Of Radionuclides Currently Used In Prrtmentioning

confidence: 99%

“…Indium-111 is produced commercially by irradiating a natural cadmium target with high-energy protons in a cyclotron according to the 111 Cd(p,n) 111 In or 112 Cd(p,2n) 111 In reaction, and both remain the most widely used 111 In production methods. [31][32][33] When production of 111 In is carried out by bombarding the Cd target with protons, the 111 In activity at the end of bombardment (EOB) contains radionuclidic contaminations, such as 109 In (t ½ = 4.3 hours), 110m In (t ½ = 4.9 hours), and 114m In (t ½ = 49 days). The first two radionuclides of indium have a relatively short half-life and hence cooling for 24 hours after EOB will reduce their contaminations.…”

Section: Production Of Radionuclides Currently Used In Prrtmentioning

confidence: 99%

Peptide Receptor Radionuclide Therapy: An Overview

Dash

Chakraborty

Pillai³

et al. 2015

Cancer Biotherapy and Radiopharmaceuticals

102

101

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Peptide receptor radionuclide therapy (PRRT) is a site-directed targeted therapeutic strategy that specifically uses radiolabeled peptides as biological targeting vectors designed to deliver cytotoxic levels of radiation dose to cancer cells, which overexpress specific receptors. Interest in PRRT has steadily grown because of the advantages of targeting cellular receptors in vivo with high sensitivity as well as specificity and treatment at the molecular level. Recent advances in molecular biology have not only stimulated advances in PRRT in a sustainable manner but have also pushed the field significantly forward to several unexplored possibilities. Recent decades have witnessed unprecedented endeavors for developing radiolabeled receptor-binding somatostatin analogs for the treatment of neuroendocrine tumors, which have played an important role in the evolution of PRRT and paved the way for the development of other receptor-targeting peptides. Several peptides targeting a variety of receptors have been identified, demonstrating their potential to catalyze breakthroughs in PRRT. In this review, the authors discuss several of these peptides and their analogs with regard to their applications and potential in radionuclide therapy. The advancement in the availability of combinatorial peptide libraries for peptide designing and screening provides the capability of regulating immunogenicity and chemical manipulability. Moreover, the availability of a wide range of bifunctional chelating agents opens up the scope of convenient radiolabeling. For these reasons, it would be possible to envision a future where the scope of PRRT can be tailored for patient-specific application. While PRRT lies at the interface between many disciplines, this technology is inextricably linked to the availability of the therapeutic radionuclides of required quality and activity levels and hence their production is also reviewed.

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“…The efficiency versus energy curves of the HPGe-detector for the counting distances was determined using the standard point sources, 133 Ba, 109 Cd, 22 Na, 60 Co, 57 Co, 54 Mn, and 137 Cs. The proton beam intensity was determined from the measured activities induced in aluminum and copper monitor foils at front of stack using the reactions, 27 Al(p,x) 22,24 Na and nat Cu(p,x) 62 Zn, respectively. It was considered the monitor foils were irradiated simultaneously and measured with the same detector and in a comparable geometry as the Cd target.…”

Section: Experimental Techniquementioning

confidence: 99%

Experimental Study of Proton Induced Cross-sections on Natural Cadmium Leading to the Production of¹¹¹Radionuclide

Khandaker¹,

Kim²,

Lee³

et al. 2008

Journal of Nuclear Science and Technology

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We measured the production cross-sections of 111 In induced by proton on the nat Cd at several proton energies between 4 MeV and 40 MeV by using a stacked-foil activation technique at the MC50 cyclotron of the Korea Institute of Radiological and Medical Sciences. The present results were compared with the earlier reported experimental data and the theoretical calculations by using both the TALYS code and the ALICE-IPPE code. An overall good agreement was found with the recently reported experimental data and the TALYS prediction, as well. Integral yields of 111 In were also deduced from the measured cross-sections.

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Excitation functions and yields for 111In production using 113, 114,natCd(p,xn)111In reactions with 65 MeV protons

Cited by 27 publications

References 19 publications

Production of ¹¹¹In and ^114mIn by proton induced reactions: an update on excitation functions, chemical separation – purification and recovery of target material

Production of ¹¹¹In and ^114mIn by proton induced reactions: an update on excitation functions, chemical separation – purification and recovery of target material

Peptide Receptor Radionuclide Therapy: An Overview

Experimental Study of Proton Induced Cross-sections on Natural Cadmium Leading to the Production of¹¹¹Radionuclide

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Excitation functions and yields for 111In production using 113, 114,natCd(p,xn)111In reactions with 65 MeV protons

Cited by 27 publications

References 19 publications

Production of 111In and 114mIn by proton induced reactions: an update on excitation functions, chemical separation – purification and recovery of target material

Production of 111In and 114mIn by proton induced reactions: an update on excitation functions, chemical separation – purification and recovery of target material

Peptide Receptor Radionuclide Therapy: An Overview

Experimental Study of Proton Induced Cross-sections on Natural Cadmium Leading to the Production of111Radionuclide

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Product

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Production of ¹¹¹In and ^114mIn by proton induced reactions: an update on excitation functions, chemical separation – purification and recovery of target material

Production of ¹¹¹In and ^114mIn by proton induced reactions: an update on excitation functions, chemical separation – purification and recovery of target material

Experimental Study of Proton Induced Cross-sections on Natural Cadmium Leading to the Production of¹¹¹Radionuclide