Excitation functions of proton- and deuteron-induced nuclear reactions on natural iridium for the production of 191 Pt

Obata, Honoka; Khandaker, Mayeen Uddin; Furuta, Etsuko; Nagatsu, Kotaro; Zhang, Ming‐Rong

doi:10.1016/j.apradiso.2018.03.021

Cited by 9 publications

(2 citation statements)

References 19 publications

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“…In HPGe γ-ray spectrometry, only 188,189,191 Pt were detected, and other coexistent radionuclides in a stock solution (e.g., 190g, 192g Ir) were below the detection limit after puri cation with QMA-AEC. Due to the overlapping nuclear reaction channels, the product included not only 191 Pt but also 188,189 Pt [34].…”

Section: Methodsmentioning

confidence: 99%

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Synthesis of n.c.a. [188, 189, 191pt] Cisplatin From a Cyclotron-produced n.c.a. 188, 189, 191PtCl42- Complex

Obata¹,

Minegishi²,

Nagatsu³

et al. 2020

Preprint

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We developed a novel method for production of no-carrier-added (n.c.a.) [188, 189, 191Pt]PtⅡCl42- from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[PtⅡCl2(NH3)2] ([*Pt]cisplatin) from [*Pt]PtⅡCl42-. [*Pt]PtⅡCl42- was prepared as a synthetic precursor of n.c.a. *Pt complex by a combination of resin extraction and anion-exchange chromatography after the selective reduction of IrⅣCl62- with ascorbic acid. The ligand-substitution reaction of Cl with NH3 was promoted by treating n.c.a. [*Pt]PtⅡCl42- with excess NH3 and heating the reaction mixture, and n.c.a [*Pt]cisplatin was successfully produced without employing precipitation routes. After this treatment, [*Pt]cisplatin was isolated through preparative HPLC with a radiochemical purity of 99+% at the end of synthesis (EOS).

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Section: Methodsmentioning

confidence: 99%

“…Therefore, we demonstrated the production of n.c.a. 191 Pt from an Ir target using a cyclotron [34,35]. In this work, we established a procedure for producing n.c.a.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of n.c.a. [188, 189, 191pt] Cisplatin From a Cyclotron-produced n.c.a. 188, 189, 191PtCl42- Complex

Obata¹,

Minegishi²,

Nagatsu³

et al. 2020

Preprint

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Building up Pt^II−Thiosemicarbazone−Lysine−sC18 Conjugates

et al. 2020

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Three chiral tridentate N^N^S coordinating pyridine‐carbaldehyde (S)‐N4‐(α‐methylbenzyl)thiosemicarbazones (HTSCmB) were synthesised along with lysine‐modified derivatives. One of them was selected and covalently conjugated to the cell‐penetrating peptide sC18 by solid‐phase peptide synthesis. The HTSCmB model ligands, the HTSCLp derivatives and the peptide conjugate rapidly and quantitatively form very stable PtII chlorido complexes [Pt(TSC)Cl] when treated with K2PtCl4 in solution. The Pt(CN) derivatives were obtained from one TSCmB model complex and the peptide conjugate complex through Cl−→CN− exchange. Ligands and complexes were characterised by NMR, IR spectroscopy, HR‐ESI‐MS and single‐crystal XRD. Intriguingly, no decrease in cell viability was observed when testing the biological activity of the lysine‐tagged HdpyTSCLp, its sC18 conjugate HdpyTSCL‐sC18 or the PtCl and Pt(CN) conjugate complexes in three different cell lines. Thus, given the facile and effective preparation of such Pt‐TSC‐peptide conjugates, these systems might pave the way for future use in late‐stage labelling with Pt radionuclides and application in nuclear medicine.

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Production of 191Pt from an iridium target by vertical beam irradiation and simultaneous alkali fusion

Obata

Minegishi

Nagatsu

et al. 2019

Applied Radiation and Isotopes

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Excitation functions of proton- and deuteron-induced nuclear reactions on natural iridium for the production of 191 Pt

Cited by 9 publications

References 19 publications

Synthesis of n.c.a. [188, 189, 191pt] Cisplatin From a Cyclotron-produced n.c.a. 188, 189, 191PtCl42- Complex

Synthesis of n.c.a. [188, 189, 191pt] Cisplatin From a Cyclotron-produced n.c.a. 188, 189, 191PtCl42- Complex

Building up Pt^II−Thiosemicarbazone−Lysine−sC18 Conjugates

Production of 191Pt from an iridium target by vertical beam irradiation and simultaneous alkali fusion

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Excitation functions of proton- and deuteron-induced nuclear reactions on natural iridium for the production of 191 Pt

Cited by 9 publications

References 19 publications

Synthesis of n.c.a. [188, 189, 191pt] Cisplatin From a Cyclotron-produced n.c.a. 188, 189, 191PtCl42- Complex

Synthesis of n.c.a. [188, 189, 191pt] Cisplatin From a Cyclotron-produced n.c.a. 188, 189, 191PtCl42- Complex

Building up PtII−Thiosemicarbazone−Lysine−sC18 Conjugates

Production of 191Pt from an iridium target by vertical beam irradiation and simultaneous alkali fusion

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Product

Resources

About

Building up Pt^II−Thiosemicarbazone−Lysine−sC18 Conjugates